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公开(公告)号：EP4134446A1
公开(公告)日：2023-02-15
申请号：EP21194884.9
申请日：2021-09-03
发明人： COSTA DO AMARAL RAMOS, ANTÓNIO MARCOS , USIÉ CHIMENOS, ANA ISABEL , BRANCO GASPAR, DANIEL FILIPE , PINHEIRO RIBEIRO DE MEIRELES, BRÍGIDA DA NATIVIDADE , CARVALHO MAGALHÃES, HUGO , SANTOS BARBOSA, PEDRO , FIALHO LEÃO, CÉLIA CRISTINA
IPC分类号： C12Q1/6876
摘要： The present patent application discloses a method for the genetic selection of animals from the Alentejano pig breed with a profile associated with increased reproductive traits. Said profile is determined based on a group of Single Nucleotide Polymorphisms (SNPs) herein associated with increased reproductive traits in the Alentejano pig breed.
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公开(公告)号：EP4117741A1
公开(公告)日：2023-01-18
申请号：EP21719023.0
申请日：2021-03-10
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公开(公告)号：EP4230701A1
公开(公告)日：2023-08-23
申请号：EP22216793.4
申请日：2022-12-27
发明人： FIALHO CAEIRO CALDEIRA, Ana Teresa , DEOMÉTRIO RODRIGUES LOURENÇO PEREIRA, António Manuel , CACHOLA EUSTÁQUIO, Raquel , CRISTÓVÃO PRATES RAMALHO, Joâo Paulo , ESTEVÃO GRANDE CANDEIAS, António José
IPC分类号： C09B23/14 , C09K11/06 , G01N33/533
摘要： Important scientific areas such as cellular biology, medicine, pharmacy, environmental sciences are dependent on very sensitive analytical techniques to track and detect biomolecules. The present application discloses a simple, low cost and effective synthetic strategy to produce new red-shifted 4-styrylcoumarin derivatives of Formulas I, II, III and IV as promising inexpensive fluorescent labels for biomolecules. The extension of the delocalized π-electron system results in bathochromic shifts in these new coumarin derivatives, which also present large Stokes shifts. In addition, density functional theory and time dependent density functional theory calculations helped to rationalize photophysical properties observed by the experimental results.
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公开(公告)号：EP3530382B1
公开(公告)日：2023-06-28
申请号：EP17817095.7
申请日：2017-10-23
发明人： CARVALHO CUNHA DE BRITO E FARO, Tiago Maria , MARTINS ESTEVES, António José , ROSAS COUTINHO, Filipe , CARDOSO DOS SANTOS, João Paulo
IPC分类号： B22F3/105 , B29C64/153 , B29C64/371 , B33Y30/00 , B33Y40/00 , B22F12/41 , B22F12/49 , B22F12/90
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公开(公告)号：EP3775851B1
公开(公告)日：2023-06-07
申请号：EP19724610.1
申请日：2019-04-10
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公开(公告)号：EP4186179A1
公开(公告)日：2023-05-31
申请号：EP21748670.3
申请日：2021-07-21
IPC分类号： H04B10/075 , G01M11/00 , G02B6/42
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公开(公告)号：EP4183795A1
公开(公告)日：2023-05-24
申请号：EP22198181.4
申请日：2016-01-29
发明人： Volker Côrte-Real, Sofia , Santos Neves, Vera Luísa , Correia Canhão, Pedro Manuel , Fleming Outeiro, Tiago , Rico Botas Castanho, Miguel Augusto , Castanheira Aires da Silva, Frederico Nuno
摘要： The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of Alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier. The invention also relates to constructs of the antibody molecules and the delivery peptides, as well as pharmaceutical compositions comprising effective amounts of the antibody molecules, delivery peptides, and/or their constructs, including humanized versions of the antibody molecules and constructs. The invention further relates to methods of making these products and pharmaceutical compositions thereof; and methods of using the pharmaceutical compositions in treating or preventing Alzheimer's and related disorders, such as those involving accumulation of beta-amyloid peptide or other peptides that aggregate in the brain; as well as to methods and kits for diagnosing these disorders.
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公开(公告)号：EP4134447A1
公开(公告)日：2023-02-15
申请号：EP21194900.3
申请日：2021-09-03
申请人： ACOS - Associação de Agricultores do Sul , Cebal - Centro De Biotecnologia Agrícola E Agro-Alimentar Do Alentejo , Universidade De Évora , INIAV - Instituto Nacional de Investigação Agrária E Veterinária
发明人： PEREIRA MATOS, CLAUDINO ANTÓNIO , COSTA DO AMARAL RAMOS, ANTÓNIO MARCOS , USIÉ CHIMENOS, ANA ISABEL , BRANCO GASPA, DANIEL FILIPER , GODINHO VIEIRA MONTEIRO, MARIA HELENA , FIALHO LEÃO, CÉLIA CRISTINA , PIMENTEL CAROLINO, RENATO NUNO , DA SILVA BRANCO, SANDRA MARIA , NETO PADRE, LUDOVINA , VARELA BETTENCOURT HENRIQUES, ELISA MARIA , DE SOUSA HENRIQUES, PEDRO DAMIÃO
IPC分类号： C12Q1/6883 , C12Q1/689
摘要： The present patent application discloses a method for prognosis and characterization of sheep footrot based on the use of data produced using state-of-the-art sequencing techniques to characterize the composition of the microbiome associated with the foot rot in sheep. This characterization is done qualitatively, by identifying the species of bacteria present in the microbiome of each sample collected, but also quantitatively, as the abundance of each species, in each sample analyzed, is also determined. Subsequently, in situations where the observed score for the footrot is available for each animal, it is possible to identify the most important differences between animals not affected by footrot and those more affected by this disease.
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公开(公告)号：EP4134445A1
公开(公告)日：2023-02-15
申请号：EP21194880.7
申请日：2021-09-03
申请人： Cebal - Centro De Biotecnologia Agrícola E Agro-Alimentar Do Alentejo , Universidade De Évora , INIAV - Instituto Nacional de Investigação Agrária E Veterinária
发明人： COSTA DO AMARAL RAMOS, ANTÓNIO MARCOS , USIÉ CHIMENOS, ANA ISABEL , BRANCO GASPAR, DANIEL FILIPE , PINHEIRO RIBEIRO DE MEIRELES, BRÍGIDA DA NATIVIDADE , CARVALHO MAGALHÃES, HUGO , MOTA RUIVO MARTINS, JOSÉ MANUEL , SANTOS BARBOSA, PEDRO , FIALHO LEÃO, CÉLIA CRISTINA , CARRACHA CHARNECA, RUI MIGUEL , SOUSA JERÓNIMO, ELIANA ALEXANDRA , SARGENTO CACHUCHO, LILIANA MARGARIDA , PIMENTEL CAROLINO, RENATO NUNO
IPC分类号： C12Q1/6876
摘要： The present patent application discloses a method for the genetic selection of animals from the Alentejano pig breed with a genetic profile associated with better meat quality and higher growth. Said profile is determined based on a group of Single Nucleotide Polymorphisms (SNPs) herein associated with better meat quality and higher growth in the Alentejano pig breed.
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