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157 条记录 (耗时 0.017 秒)

    Cephalosporin derivative
    21.
    发明公开
    Cephalosporin derivative 失效
    头孢菌素衍生金融工具。

    公开(公告)号：EP0463553A1

    公开(公告)日：1992-01-02

    申请号：EP91110030.3

    申请日：1991-06-19

    申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

    发明人： Ludescher, Johannes ,  Wieser, Josef

    IPC分类号： C07D501/36

    CPC分类号： C07D501/00

    摘要： The application relates to a highly pure crystalline modification of cefcanel daloxate hydrochloride (I) and processes for its production.

    摘要翻译： 本申请涉及一种高纯度的Cefcanel daloxate hydrochloride（I）的结晶改性及其生产方法。 p

    Cephalosporin derivative
    22.
    发明公开
    Cephalosporin derivative 失效
    Cephalosporinderivat。

    公开(公告)号：EP0439097A2

    公开(公告)日：1991-07-31

    申请号：EP91100697.1

    申请日：1991-01-21

    申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

    发明人： Ascher, Gerd ,  Sturm, Hubert

    IPC分类号： C07D501/36

    CPC分类号： C07D501/00

    摘要： The invention relates to a nitrate of (6R,7R)-7-{[2-(2-amino-4--thiazolyl)]-2-oxoacetamido}-3-(1,2,3-thiadiazol-5-yl)thiomethyl--3-cephem-4-carboxylic acid, a process for its production and its use.

    摘要翻译： 本发明涉及（6R，7R）-7 - {[2-（2-氨基-4-噻唑基）] -2-氧代乙酰氨基} -3-（1,2,3-噻二唑-5-基） 吡啶-4-基）硫甲基-3-头孢烯-4-羧酸，其制备方法及其用途。

    Cephalosporins
    27.
    发明公开
    Cephalosporins 失效
    头孢菌素

    公开(公告)号：EP0156771A3

    公开(公告)日：1986-03-19

    申请号：EP85810122

    申请日：1985-03-22

    申请人： BIOCHEMIE Gesellschaft m.b.H.

    发明人： Prager, Bernhard Christian ,  Thaler, Heinrich ,  Sturm Hubert

    IPC分类号： C07D501/06 ,  C07D277/74

    CPC分类号： C07D277/74 ,  Y02P20/55

    摘要： A process for the preparation of compounds of formula I
    wherein R 1 represents hydrogen or a hydroxy-proctecting group,
    R 2 represents hydrogen, a cation, the pivaloyloxymethyl group or a carboxy-protecting group and R 3 represents hydrogen, the acetoxy group, the carbamoyloxy group, a group S-Y whereby Y represents an unsubstituted or substituted heterocycle, or an optionally substituted pyridinium of formula
    whereby R 4 and R. are the same or different and each represent hydrogen, halogen, alkyl, hydroxy, carboxamido, alkoxycarbonyl amino, monoalkylamino or di-alkylamino or together represent an optionally substituted 5- or 6-membered carbocyclic ring, characterised by reacting a compound of formula IV
    wherein R, represents a hydroxy protecting group and
    represents a 5- or 6-membered heterocycle which may contain in addition to the nitrogen atom one or two further heteroatoms and which may be substituted or anellated with an optionally substituted benzene ring with a compound of formula III and if desired deprotecting the obtained end product and optionally converting an obtained product into a salt or vice-versa.

    Cephalosporins
    28.
    发明公开
    Cephalosporins 失效
    Cephalosporinverbindungen。

    公开(公告)号：EP0156771A2

    公开(公告)日：1985-10-02

    申请号：EP85810122.3

    申请日：1985-03-22

    申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

    发明人： Prager, Bernhard Christian ,  Thaler, Heinrich ,  Sturm Hubert

    IPC分类号： C07D501/06

    CPC分类号： C07D277/74 ,  Y02P20/55

    摘要： A process for the preparation of compounds of formula I
    wherein R 1 represents hydrogen or a hydroxy-proctecting group,

    R 2 represents hydrogen, a cation, the pivaloyloxymethyl group or a carboxy-protecting group and
    R 3 represents hydrogen, the acetoxy group, the carbamoyloxy group, a group S-Y whereby Y represents an unsubstituted or substituted heterocycle, or an optionally substituted pyridinium of formula
    whereby R 4 and R. are the same or different and each represent hydrogen, halogen, alkyl, hydroxy, carboxamido, alkoxycarbonyl amino, monoalkylamino or di-alkylamino or together represent an optionally substituted 5- or 6-membered carbocyclic ring, characterised by reacting a compound of formula IV
    wherein R, represents a hydroxy protecting group and
    represents a 5- or 6-membered heterocycle which may contain in addition to the nitrogen atom one or two further heteroatoms and which may be substituted or anellated with an optionally substituted benzene ring with a compound of formula III and if desired deprotecting the obtained end product and optionally converting an obtained product into a salt or vice-versa.

    摘要翻译： 制备式I化合物的方法其中R1表示氢或羟基取代基，R2表示氢，阳离子，新戊酰氧基甲基或羧基保护基，R3表示氢，乙酰氧基， 氨基甲酰氧基，基团SY，其中Y表示未取代或取代的杂环，或任选取代的式CHEM的吡啶鎓，其中R 4和R 5相同或不同，各自表示氢，卤素，烷基，羟基，甲酰氨基，烷氧基羰基氨基， 单烷基氨基或二烷基氨基或一起代表任选取代的5-或6-元碳环，其特征在于使式IV的化合物其中R 1表示羟基保护基，而CHEM>代表5-或6-元环 可以除了氮原子外可以含有一个或两个另外的杂原子并且可以被任选取代的苯环取代或被取代或取代的杂环 与式III化合物反应，如果需要，将得到的最终产物脱保护，并任选地将所得产物转化成盐，反之亦然。