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公开(公告)号：EP4431602A1
公开(公告)日：2024-09-18
申请号：EP22892975.8
申请日：2022-07-26
申请人： Inibio Co., Ltd.
发明人： KIM, Chung Sei , YIM, Hyeon A , KIM, Young Je , AN, Yeong Duk
摘要： The present invention relates to a method for drying botulinum toxin under reduced pressure. In the case of using a method for preparing a botulinum toxin dried cake according to this method for drying under reduced pressure, the drying time can be significantly shortened while maintaining the efficacy of the botulinum toxin.
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公开(公告)号：EP4335303A3
公开(公告)日：2024-05-22
申请号：EP23218309.5
申请日：2018-09-07
发明人： FIRST, Eric , BROWN, David , STONE, Albert, Archie
CPC分类号： A61M5/142 , A61K9/0029 , C12N9/20 , C12N9/2411 , C12N9/50 , A61K38/465 , A61K38/47 , A61K38/48 , C12Y304/00 , C12Y301/01003 , C12Y302/01001 , A61J15/0076 , A23L29/06 , A23L33/40 , A61M5/1409 , A61M5/16827
摘要： CROSS-REFERENCE TO RELATED APPLICATIONS
Exemplary embodiments of the disclosure may be drawn to a device having an inlet and a chamber. Immobilized lipase, immobilized protease, and immobilized amylase may be contained within the chamber. The device may also include an outlet, wherein a flow path extends from the inlet, through the chamber, and to the outlet.-
3.发明公开
公开(公告)号：EP4365191A1
公开(公告)日：2024-05-08
申请号：EP22833489.2
申请日：2022-06-21
申请人： Medytox Inc.
发明人： RHEE, Chang Hoon , KIM, Kook Han , LEE, In Tae , KWAK, Seong Sung , AN, Dong Hyun , LEE, Young Rae , CHOI, Hwa Jung
摘要： The present disclosure is to provide a recombinant botulinum toxin type A light chain, a recombinant botulinum toxin, and a composition, use, and method related thereto, which exhibit improved efficacy and half-life to be easier to use for patients and enable treatment that is customized to indications.
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4.发明公开
公开(公告)号：EP4365190A1
公开(公告)日：2024-05-08
申请号：EP22833488.4
申请日：2022-06-21
申请人： Medytox Inc.
发明人： RHEE, Chang Hoon , KIM, Kook Han , LEE, In Tae , KWAK, Seong Sung , AN, Dong Hyun , LEE, Young Rae , CHOI, Hwa Jung
摘要： The purpose of the present invention is to provide a recombinant botulinum toxin type A light chain in which efficacy and half-life are increased to increase patient convenience and allow for customized treatment for indications, a recombinant botulinum toxin, and a composition, use, and method related thereto.
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公开(公告)号：EP3400958A1
公开(公告)日：2018-11-14
申请号：EP18162586.4
申请日：2012-08-10
发明人： SIEGEL, Justin , BAKER, David , GORDON, Sydney, Rin Anna , PULTZ, Ingrid, Swanson , STANLEY, Elizabeth, Joy , WOLF, Sarah, Jane
CPC分类号： A61K38/482 , A61K38/48 , C12N9/50 , C12N9/52 , C12Y304/21
摘要： The invention provides compositions and methods for treating celiac sprue.
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6.发明公开
公开(公告)号：EP3393502A2
公开(公告)日：2018-10-31
申请号：EP16876878.6
申请日：2016-12-16
申请人： Nepetx, LLC
发明人： SCHRIEMER, David C. , REY, Martial
CPC分类号： A61K38/488 , A61K9/0053 , A61K38/48 , A61K45/06 , C12Y304/23012
摘要： The invention described herein relates to methods and compositions for treatment of one or more symptoms of gluten intolerance and related conditions (e.g., celiac disease and gluten sensitivity) by administration of a pharmaceutical composition comprising one or more Nepenthes enzymes.
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公开(公告)号：EP2782458B1
公开(公告)日：2018-09-12
申请号：EP12787031.9
申请日：2012-11-19
申请人： DSM IP Assets B.V. , Novozymes A/S
发明人： WARD , Nelson , KNAP, Inge
IPC分类号： A23K10/18 , A23K20/174 , A23K20/189 , A23K10/14 , A23K20/24 , A23K20/22 , A23K20/26 , A23K20/28 , A23K20/20 , A23K50/70 , A23K50/75 , A61K38/48 , A61K39/012 , A23K20/10 , A61K38/47
CPC分类号： A61K38/48 , A23K10/14 , A23K10/18 , A23K20/10 , A23K20/174 , A23K20/189 , A23K20/22 , A23K20/24 , A23K20/26 , A23K20/28 , A23K20/30 , A23K50/70 , A23K50/75 , A23V2002/00 , A61K38/47 , A61K39/012 , A61K2039/543 , A61K2039/552 , C12Y302/00 , C12Y302/01004 , C12Y302/01008 , C12Y304/00 , C12Y304/21014 , A23V2200/32
摘要： The invention relates to the use of at least one acid stable protease in poultry feed in combination with anti-coccidial vaccination of birds for increasing the performance of vaccinated animals. It has been found surprisingly that the additions of at least one acid stable protease according to the invention to the diet of “cocci”-vaccinated birds have a significant improvement of animal performance. The inventors found that especially the use of serin proteases improve the performance of vaccinated broiler chickens, in particular the use of serin proteases increases weight gain and improves Feed Conversion Ratio (FCR) of cocci-vaccinated birds.
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公开(公告)号：EP2809336B1
公开(公告)日：2018-06-20
申请号：EP13701651.5
申请日：2013-01-31
申请人： CSL Behring GmbH , CSL Limited , Julius-Maximilians-Universitaet Wuerzburg , Westfälische Wilhelms-Universität Münster
IPC分类号： A61K38/06 , A61K38/48 , A61K38/55 , A61K38/57 , A61K39/395 , A61K47/50 , C07K14/81 , C07K16/36 , C07K16/40 , A61P25/00 , A61P37/00 , A61K38/17
CPC分类号： C07K16/40 , A61K38/06 , A61K38/16 , A61K38/1774 , A61K38/48 , A61K38/4846 , A61K38/55 , A61K38/556 , A61K38/57 , A61K39/395 , A61K2039/505 , C07K14/811 , C07K16/36 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： This application relates to neurological inflammatory diseases, such as multiple sclerosis, and to methods of administering a Factor XII inhibitor to prevent, treat, or otherwise ameliorate the effects of a neurological inflammatory disease, such as multiple sclerosis. Agents and pharmaceutical compositions comprising agents which inhibit the activity of FXII are also provided.
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公开(公告)号：EP3324987A1
公开(公告)日：2018-05-30
申请号：EP16828680.5
申请日：2016-07-25
申请人： EnBiotix, Inc.
CPC分类号： A61K35/76 , A61K38/10 , A61K38/1729 , A61K38/1767 , A61K38/47 , A61K38/48 , C12N7/00 , C12N2795/10221 , C12N2795/10232 , C12Q1/14 , C12Q1/689 , C12Y302/01017 , C12Y302/01052 , C12Y304/24075 , G01N2333/31
摘要： The present invention relates to GRCS bacteriophages, as well as to methods and compositions for the treatment of prosthetic joint infection. Particularly, the present invention provides bacteriophages specific against Staphylococcus aureus from prosthetic joint infections.
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10.发明公开BOTULINUM TOXIN-HUMAN EPIDERMAL GROWTH FACTOR FUSION PROTEIN HAVING IMPROVED SKIN CELL PROLIFERATION AND ANTIOXIDANT EFFECT, AND COSMETIC COMPOSITION CONTAINING SAME AS EFFECTIVE INGREDIENT FOR SKIN REGENERATION AND WRINKLE IMPROVEMENT 有权具有改善皮肤细胞增殖和抗氧化作用的肉毒杆菌毒素 - 人表皮生长因子融合蛋白，以及含有用于皮肤再生和改善皱纹的有效成分的化妆品组合物
公开(公告)号：EP3299385A1
公开(公告)日：2018-03-28
申请号：EP16904720.6
申请日：2016-07-22
发明人： LEE, Sun Kyo , RYU, Han Bong , LEE, Seong Ran , CHOI, Jong Nam , CHOI, Tae Won , KIM, Tae Hyun , JEONG, Tae Hwa , KWON, Hyeong Il
CPC分类号： C12N9/52 , A61K8/64 , A61K8/66 , A61K38/18 , A61K38/48 , A61Q19/00 , A61Q19/08 , C07K14/33 , C07K14/485 , C07K2319/55 , C07K2319/75 , C12N15/62 , C12N15/70 , C12Y304/24069
摘要： The present invention relates to a botulinum toxin-human epidermal growth factor fusion protein with increased skin cell proliferation and anti-oxidation effect which consists of the amino acid sequence of SEQ ID NO: 2, a gene consisting of E. coli ( Escherichia coli ) codon-optimized nucleotide sequence of SEQ ID NO: 1 for encoding the botulinum toxin-human epidermal growth factor fusion protein, a recombinant vector comprising the aforementioned gene, a host cell transformed with the aforementioned recombinant vector, and a method for producing a botulinum toxin-human epidermal growth factor fusion protein by transforming a host cell with the aforementioned recombinant vector, and a cosmetic composition for regenerating skin and improving skin wrinkle comprising, as an effective component, a botulinum toxin-human epidermal growth factor fusion protein, and as the cosmetic composition of the present invention has an effect of regenerating skin and improving skin wrinkle, it can be advantageously used in future in the field of cosmetics or cosmetic plastic surgery.
摘要翻译： 本发明涉及具有增加的皮肤细胞增殖和抗氧化作用的肉毒杆菌毒素 - 人表皮生长因子融合蛋白，其由SEQ ID NO：2的氨基酸序列，由大肠杆菌（Escherichia coli）组成的基因， 用于编码肉毒杆菌毒素 - 人表皮生长因子融合蛋白的SEQ ID NO：1的密码子优化的核苷酸序列，包含上述基因的重组载体，用上述重组载体转化的宿主细胞以及肉毒杆菌毒素的生产方法 通过用上述重组载体转化宿主细胞来获得人表皮生长因子融合蛋白，以及用于再生皮肤和改善皮肤皱纹的化妆品组合物，其包含作为有效成分的肉毒杆菌毒素 - 人表皮生长因子融合蛋白，以及作为 本发明的化妆品组合物具有再生皮肤和改善皮肤皱纹的作用，它可以是更好的 将来在化妆品或美容整形外科领域中将被严格使用。
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