公开(公告)号：EP4095262A2

公开(公告)日：2022-11-30

申请号：EP22165085.6

申请日：2018-10-26

申请人： SYSMEX CORPORATION

发明人： Suzuki, Kenichiro ,  Suzuki, Seigo ,  Watanabe, Reiko ,  Sato, Jun ,  Sawa, Kenichi ,  Mino, Kenjiro ,  Oka, Akihide

IPC分类号： C12Q1/6869

摘要： Disclosed is a quality evaluation method performed in a genetic test for testing a gene in a sample collected from a subject, for a plurality of types of gene mutations that include a first type gene mutation and a second type gene mutation different from the first type gene mutation, and the quality evaluation method includes: preparing a quality control sample that includes a first reference gene having the first type gene mutation, and a second reference gene having the second type gene mutation; obtaining sequence information of the genes included in the quality control sample; and outputting an index for evaluation of a quality of the genetic test, based on the sequence information having been obtained.

公开(公告)号：EP4095154A1

公开(公告)日：2022-11-30

申请号：EP20915286.7

申请日：2020-12-18

申请人： Sysmex Corporation

发明人： MAETA, Shingo ,  FUKUNAGA, Atsushi ,  BAJAJ, Reema

IPC分类号： C07K16/00 ,  C12N15/13 ,  C12Q1/68

摘要： The present invention relates to a method for improving affinity of an antibody for an antigen. The present invention relates to a modified antibody with improved affinity for an antigen as compared to an unmodified antibody. The present invention relates to a method for producing an antibody with improved affinity for an antigen as compared to an unmodified antibody. The present invention relates to a method for analyzing an amino acid sequence of an antibody. The present invention relates to a method for specifying candidates for an antibody modification site.

公开(公告)号：EP4063515A1

公开(公告)日：2022-09-28

申请号：EP22163963.6

申请日：2022-03-24

申请人： SYSMEX CORPORATION

发明人： KIRIYAMA, Maria ,  TAMADA, Eiya ,  NAKHAEI, Elnaz ,  ONISHI, Mami

IPC分类号： C12Q1/42 ,  G01N33/68

摘要： Disclosed is a method of determining onset risk of cardiovascular disease in a subject, the method comprising:
capturing, on a solid phase, an extracellular vesicle derived from a blood sample collected from the subject; and
measuring alkaline phosphatase activity of the extracellular vesicle,
a measured result of the alkaline phosphatase activity being directed for use as an index of the onset risk of cardiovascular disease in the subject.

公开(公告)号：EP4053842A1

公开(公告)日：2022-09-07

申请号：EP22160175.0

申请日：2022-03-04

申请人： SYSMEX CORPORATION ,  OSAKA UNIVERSITY ,  National Institute Of Advanced Industrial Science and Technology

发明人： Okada, Masaya ,  Shimaoka, Yuki ,  Iwanaga, Shigeki ,  Bando, Kazuki ,  Fujita, Katsumasa ,  Nawa, Yasunori ,  Fujita, Satoshi

IPC分类号： G16C20/20

摘要： Disclosed is an analytical method for analyzing a test substance contained in a measurement sample, the method comprising: generating a data set based on a plurality of optical spectra acquired from a plurality of locations in the measurement sample; inputting the data set into a deep learning algorithm having a neural network structure; and outputting information on the test substance, on the basis of an analytical result from the deep learning algorithm.

公开(公告)号：EP4053564A1

公开(公告)日：2022-09-07

申请号：EP22159970.7

申请日：2022-03-03

申请人： SYSMEX CORPORATION

发明人： WAKAMIYA, Yuji ,  UEMURA, Toru ,  OHMAE, Yuichiro ,  HAYAMA, Hidetaka

IPC分类号： G01N35/00

摘要： Disclosed is a quality control method of a specimen analysis system, comprising: cooling and storing a quality control material comprising a cell of known concentration; heating the cooled and stored quality control material; transporting the heated quality control material to an analyzer; and measuring the quality control material by the analyzer.

公开(公告)号：EP4053562A1

公开(公告)日：2022-09-07

申请号：EP22159954.1

申请日：2022-03-03

申请人： SYSMEX CORPORATION

发明人： WAKAMIYA, Yuji ,  UEMURA, Toru ,  OHMAE, Yuichiro ,  HAYAMA, Hidetaka

IPC分类号： G01N35/00

摘要： Disclosed is a method for controlling a specimen analysis system comprising at least one measurement unit, the method comprising: automatically starting at least one measurement unit according to a schedule registered by a user; automatically supplying a quality control specimen to the measurement unit that is automatically started; and measuring the quality control specimen by the measurement unit.

公开(公告)号：EP4053556A1

公开(公告)日：2022-09-07

申请号：EP22160173.5

申请日：2022-03-04

申请人： SYSMEX CORPORATION ,  OSAKA UNIVERSITY ,  National Institute Of Advanced Industrial Science and Technology

发明人： Shimaoka, Yuki ,  Okada, Masaya ,  Iwanaga, Shigeki ,  Bando, Kazuki ,  Fujita, Katsumasa ,  Nawa, Yasunori ,  Fujita, Satoshi

IPC分类号： G01N33/543

摘要： Disclosed is a preparation method for preparing a measurement sample comprising an aggregate of metal nanoparticles having an analyte bound thereto, the preparation method comprising: contacting the analyte with a linker to bind the analyte to the linker; and contacting the linker that has been bound to the analyte with the metal nanoparticles to bind the linker to the metal nanoparticles.

公开(公告)号：EP4047370A1

公开(公告)日：2022-08-24

申请号：EP22157860.2

申请日：2022-02-22

申请人： National Center for Global Health and Medicine ,  National Cancer Center ,  SYSMEX CORPORATION

发明人： MITSUYA, Hiroaki ,  MAEDA, Kenji ,  HAMADA, Akinobu ,  NODA, Kenta ,  YAMASHITA, Kazuto ,  ATARASHI, Yusuke ,  IDE, Nobuyuki

IPC分类号： G01N33/569 ,  G01N33/68

摘要： Disclosed is a method for acquiring information on exacerbation risk of COVID-19, comprising measuring IgM antibody against S antigen of SARS-CoV-2 contained in a specimen collected from a subject infected with SARS-CoV-2 or a subject suspected of suffering from COVID-19, wherein a value obtained by the measurement of IgM antibody serves as an index of exacerbation risk of COVID-19 of the subject.

公开(公告)号：EP4047348A1

公开(公告)日：2022-08-24

申请号：EP22155350.6

申请日：2022-02-07

申请人： SYSMEX CORPORATION

发明人： Shida, Yuki ,  Komaki, Takanori ,  Yokoyama, Daisuke ,  Abe, Masaki

IPC分类号： G01N15/14

摘要： Disclosed is a hemolytic reagent comprising a nonionic surfactant represented by formula (I) below:

         R 1 -R 2 -(CH 2 CH 2 O) n -H     Formula (I)

where Ri represents an alkyl group, an alkenyl group, or an alkynyl group having 8 or more and 25 or less carbon atoms,
R 2 represents an oxygen atom, (COO) or a group represented by formula (II) below:

where n is 23 or larger and 25 or smaller, or 30,
with n of 23 or larger and 25 or smaller, a concentration of the nonionic surfactant is 1700 ppm or higher and 2300 ppm or lower, and
with n of 30, the concentration of the nonionic surfactant is 1900 ppm or higher and 2300 ppm or lower.

公开(公告)号：EP3964838A3

公开(公告)日：2022-07-27

申请号：EP21192344.6

申请日：2021-08-20

申请人： SYSMEX CORPORATION

发明人： Kato, Akihito ,  Kurono, Hiroshi

IPC分类号： G01N35/00 ,  G01N21/27 ,  G01N21/82

摘要： Disclosed is a calibration curve setting method for setting a calibration curve, the calibration curve setting method including: creating a first calibration curve on the basis of a measurement value obtained by measuring a standard sample for which a concentration of a predetermined component is known; creating a second calibration curve by correcting the created first calibration curve; displaying a screen configured to support an operator for restoring the second calibration curve to the first calibration curve; receiving an instruction of restoring the second calibration curve to the first calibration curve; and displaying the first calibration curve upon receiving the instruction of restoring.