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21.发明公开SELECTIVE PHOTO ACTIVATION OF AMINO ACIDS FOR SINGLE STEP PEPTIDE COUPLING 审中-公开SELEKTIVE PHOTOAKTIVIERUNG VONAMINOSÄURENZUR KOPPLUNG EINSTUFIGER PEPTIDE
公开(公告)号：EP3107926A1
公开(公告)日：2016-12-28
申请号：EP15751793.9
申请日：2015-02-23
发明人： JAYARAMAN, Vasanth
摘要： Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing and using the formulations, substrates, and arrays including one-step coupling, e.g., for synthesis of peptides in a C→N orientation are disclosed. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
摘要翻译： 本文公开了用于微阵列上的氨基酸和肽合成的制剂，底物和阵列。 在某些实施方案中，公开了制备和使用包括一步偶联（例如用于合成C→N取向的肽）的制剂，底物和阵列的方法。 在一些实施方案中，本文公开了用于将生物分子高效耦合到底物的制剂和方法。
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22.发明公开
公开(公告)号：EP2956771A2
公开(公告)日：2015-12-23
申请号：EP14751871.6
申请日：2014-02-17
发明人： RAJASEKARAN, John J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari Krishnan
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
摘要翻译： 本文公开了配制剂，基质和阵列。 本文还公开了用于制造和使用制剂，基底和阵列的方法。 还公开了鉴定可用于诊断和治疗病症的肽序列的方法，以及使用该肽序列诊断和治疗病症例如乳糜泻的方法。 在某些实施方案中，基底和阵列包含用于聚合物或生物分子的合成和附着的多孔层。
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23.发明公开
公开(公告)号：EP3805207A1
公开(公告)日：2021-04-14
申请号：EP20191924.8
申请日：2015-02-23
发明人： JAYARAMAN, Vasanth
IPC分类号： C07D257/04 , C07K1/04 , C07K1/10
摘要： Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing and using the formulations, substrates, and arrays including one-step coupling, e.g., for synthesis of peptides in a C→7N orientation are disclosed. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
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公开(公告)号：EP3702782A2
公开(公告)日：2020-09-02
申请号：EP20153448.4
申请日：2014-02-17
发明人： RAJASEKARAN, John J , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari Krishnan
IPC分类号： G01N33/543
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：EP3402897A1
公开(公告)日：2018-11-21
申请号：EP16882607.1
申请日：2016-12-28
CPC分类号： C12Q1/68 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00533 , B01J2219/00596 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00729 , C12Q1/6837 , C40B50/00 , C40B50/14 , C12Q2525/107
摘要： Disclosed herein are formulations, substrates, and arrays for the synthesis of PNA chains and PNA-DNA chimera on microarrays. In some embodiments, the formulations include a photo-protective compound that shields any PNA monomers, PNA polymers, or PNA-DNA chimera already attached to a microarray from radiation exposure during the synthesis of the PNA or PNA-DNA chains. In some embodiments, substrates and arrays comprise a porous or a planar layer for synthesis and attachment of PNA or DNA monomers, or PNA or PNA-DNA polymers. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of PNA monomers or PNA polymers to a microarray substrate.
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26.发明公开
公开(公告)号：EP2956771A4
公开(公告)日：2016-08-31
申请号：EP14751871
申请日：2014-02-17
申请人： VIBRANT HOLDINGS LLC
IPC分类号： G01N33/53 , C12Q1/28 , G01N33/543
CPC分类号： G01N33/582 , G01N21/66 , G01N33/54373 , G01N33/5438 , G01N33/581
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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27.发明公开
公开(公告)号：EP2920272A2
公开(公告)日：2015-09-23
申请号：EP13798499.3
申请日：2013-11-14
发明人： RAJASEKARAN, John J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari Krishnan
IPC分类号： C09K11/64 , G01N33/68 , C07C211/62
CPC分类号： B01J19/0046 , B01J2219/00596 , B01J2219/00637 , B01J2219/00711 , B01J2219/00725 , C40B50/18 , G01N33/6842
摘要： Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N->C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
摘要翻译： 本文公开了制剂，底物和阵列。 在某些实施方案中，底物和阵列包括用于合成和附着聚合物或生物分子的多孔层。 本文还公开了用于制造和使用包括多孔阵列的制剂，基底和阵列的方法。 本文还公开了用于一步偶联的制剂和方法，例如用于以N-> C取向合成肽。 在一些实施方案中，本文公开了用于将生物分子高效耦合到底物的制剂和方法。
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