公开(公告)号：EP1638954A1

公开(公告)日：2006-03-29

申请号：EP04758050.1

申请日：2004-03-22

申请人： AMGEN INC.

发明人： DIPIETRO, Lucian V. ,  HARMANGE, Jean-Christophe ,  ASKEW, JR., Benny C. ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HABGOOD, Gregory J. ,  KIM, Joseph L. ,  PATEL, Vinod F. ,  POTASHMAN, Michele ,  VAN DER PLAS, Simon

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/4184 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D235/30 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： The invention relates to compounds of the formulae (I) to (III) wherein the substituents are as defined in the specification. These compounds have kinase inhibitory activity, such as VEGFR/KDR inhibitory activity. Accordingly, the compounds of the formulae (I) to (III) would be useful in the prevention and treatment of angiogenesis related disorders, ophthalmological conditions, proliferative diseases, inflammatory diseases, and other pathological conditions as described in the specification.

公开(公告)号：EP1358161A2

公开(公告)日：2003-11-05

申请号：EP02717324.4

申请日：2002-01-11

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  BOOKER, Shon ,  CAI, Guolin ,  CROGHAN, Michael ,  DIPIETRO, Lucian ,  DOMINGUEZ, Celia ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HUANG, Qi ,  KIM, Joseph, L. ,  KIM, Tae-Seong ,  PATEL, Vinod, F. ,  SMITH, Leon, M. ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  YUAN, Chester, Chenguang

IPC分类号： C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D405/12 ,  C07D401/14 ,  C07D413/12 ,  A61K31/44 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D213/81 ,  C07D213/82 ,  C07D237/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： Selected compounds of formula (I), wherein each of A?1 and A2¿ is independently C or N; wherein A1-A2 form part of a ring A selected from 5- or 6- membered heteroaryl; wherein X is; wherein Z is oxygen or sulfur; are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.