公开(公告)号：EP2310389A1

公开(公告)日：2011-04-20

申请号：EP09751705.6

申请日：2009-05-22

申请人： Amgen Inc.

发明人： ALBRECHT, Brian, K. ,  BELLON, Steven ,  BODE, Christiane ,  BOEZIO, Alessandro ,  CHOQUETTE, Deborah ,  HARMANGE, Jean-Christophe

IPC分类号： C07D471/04 ,  A61K31/4192 ,  A61P35/00

CPC分类号： C07D471/04

摘要： Selected fused imidazole or triazole derivatives are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1773817B1

公开(公告)日：2009-08-26

申请号：EP05791799.9

申请日：2005-07-20

申请人： Amgen Inc.

发明人： YUAN, Chester Chenguang ,  YANG, Kevin ,  VANDERPLAS, Simon ,  RIAHI, Babak ,  POTASHMAN, Michele ,  PATEL, Vinod F. ,  NOMAK, Rana ,  LI, Aiwen ,  HUANG, Qi ,  HARMANGE, Jean-Christophe ,  ASKEW, JR., Benny C.

IPC分类号： C07D401/12 ,  C07D413/14 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D217/02 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/443 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D217/02 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

公开(公告)号：EP2125780B1

公开(公告)日：2012-08-29

申请号：EP07863182.7

申请日：2007-12-19

申请人： Amgen Inc.

发明人： BELLON, Steven ,  BOOKER, Shon ,  D'ANGELO, Noel ,  GERMAIN, Julie ,  HARMANGE, Jean-Christophe ,  KIM, Tae-Seong ,  LEE, Matthew ,  LIU, Longbin ,  NORMAN, Mark H. ,  RAINBEAU, Elizabeth ,  XI, Ning ,  XU, Shimin

IPC分类号： C07D401/10

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：EP2125780A1

公开(公告)日：2009-12-02

申请号：EP07863182.7

申请日：2007-12-19

申请人： Amgen Inc.

发明人： BELLON, Steven ,  BOOKER, Shon ,  D'ANGELO, Noel ,  GERMAIN, Julie ,  HARMANGE, Jean-Christophe ,  KIM, Tae-Seong ,  LEE, Matthew ,  LIU, Longbin ,  NORMAN, Mark H. ,  RAINBEAU, Elizabeth ,  XI, Ning ,  XU, Shimin

IPC分类号： C07D401/10

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1896461A2

公开(公告)日：2008-03-12

申请号：EP06786037.9

申请日：2006-06-29

申请人： Amgen Inc.

发明人： KIM, Tae-Seong ,  HARMANGE, Jean-Christophe ,  BOOKER, Shon ,  D'ANGELO, Noel ,  DOMINGUEZ, Celia ,  FELLOWS, Ingrid, M. ,  LIU, Longbin ,  TASKER, Andrew ,  BELLON, Steven ,  HARVEY, Timothy, S. ,  LEE, Matthew ,  GERMAIN, Julie ,  PATEL, Vinod, F. ,  KIM, Joseph, L.

IPC分类号： C07D409/12 ,  C07D333/38 ,  C07D401/10 ,  C07D401/12 ,  C07D215/20 ,  C07D215/04 ,  C07D417/12 ,  A61K31/381 ,  A61K31/4725 ,  A61K31/416 ,  A61K31/4035 ,  A61P35/00

CPC分类号： C07D333/38 ,  C07D217/02 ,  C07D217/24 ,  C07D401/10 ,  C07D401/12 ,  C07D409/12 ,  C07D417/10 ,  C07D417/12

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1713484A2

公开(公告)日：2006-10-25

申请号：EP05722533.6

申请日：2005-01-24

申请人： AMGEN INC.

发明人： POTASHMAN, Michele ,  KIM, Tae-seong ,  BELLON, Steven ,  BOOKER, Shon ,  CHENG, Yuan ,  KIM, Joseph, L. ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  HARMANGE, Jean-Christophe ,  BORG, George ,  WEISS, Matthew ,  HODOUS, Brian, L. ,  GRACEFFA, Russell ,  BUCKNER, Willianm, H. ,  MASSE, Craig, E. ,  CHOQUETTE, Deborah ,  MARTIN, Matthew, W. ,  GERMAIN, Julie ,  CHAFFEE, Stuart, C. ,  NUNES, Joseph, J. ,  PATEL, Vinod, F. ,  BUCHANAN, John L. ,  DIPIETRO, Lucian V. ,  HABGOOD; Gregory J. ,  McGOWAN; David C. ,  WHITTINGTON, Douglas A. ,  LA, Daniel

IPC分类号： A61K31/505

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutically compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1638954A1

公开(公告)日：2006-03-29

申请号：EP04758050.1

申请日：2004-03-22

申请人： AMGEN INC.

发明人： DIPIETRO, Lucian V. ,  HARMANGE, Jean-Christophe ,  ASKEW, JR., Benny C. ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HABGOOD, Gregory J. ,  KIM, Joseph L. ,  PATEL, Vinod F. ,  POTASHMAN, Michele ,  VAN DER PLAS, Simon

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/4184 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D235/30 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： The invention relates to compounds of the formulae (I) to (III) wherein the substituents are as defined in the specification. These compounds have kinase inhibitory activity, such as VEGFR/KDR inhibitory activity. Accordingly, the compounds of the formulae (I) to (III) would be useful in the prevention and treatment of angiogenesis related disorders, ophthalmological conditions, proliferative diseases, inflammatory diseases, and other pathological conditions as described in the specification.

公开(公告)号：EP1427421A1

公开(公告)日：2004-06-16

申请号：EP02773237.9

申请日：2002-08-22

申请人： Amgen Inc.

发明人： HARMANGE, Jean-Christophe ,  BOOKER, Shon ,  BUCHANAN, John, L. ,  CHAFFEE, Stuart ,  NOVAK, Perry, M. ,  VAN DER PLAS, Simon ,  ZHU, Xiaotian ,  NAPIER, Spencer, Charles,R.

IPC分类号： A61K31/506 ,  A61P35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D403/12 ,  C07D403/14

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.

公开(公告)号：EP2081931B1

公开(公告)日：2016-08-31

申请号：EP07810473.4

申请日：2007-07-13

申请人： Amgen Inc.

发明人： ALBRECHT, Brian ,  BAUER, David ,  BELLON, Steven ,  BODE, Christiane ,  BOOKER, Shon ,  BOEZIO, Alessandro ,  CHOQUETTE, Deborah ,  D'AMICO, Derin ,  HARMANGE, Jean-Christophe ,  HIRAI, Satoko ,  HUNGATE, Randall ,  KIM, Tae-Seong ,  LEWIS, Richard ,  LIU, Longbin ,  LOHMAN, Julia ,  NORMAN, Mark ,  POTASHMAN, Michele ,  SIEGMUND, Aaron ,  SPRINGER, Stephanie ,  STEC, Markian ,  XI, Ning ,  YANG, Kevin

IPC分类号： C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  A61K31/5025 ,  A61K31/52 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04

公开(公告)号：EP2125781A2

公开(公告)日：2009-12-02

申请号：EP07863178.5

申请日：2007-12-19

申请人： Amgen Inc.

发明人： BELLON, Steven ,  BOOKER, Shon ,  D'ANGELO, Noel ,  FELLOWS, Ingrid M. ,  HARMANGE, Jean-Christophe ,  KIM, Tae-Seong ,  LEE, Matthew ,  LIU, Longbin ,  NORMAN, Mark H.

IPC分类号： C07D401/12

CPC分类号： C07D401/14 ,  C07D401/12

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as c-met mediated diseases and/or HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like/ The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. (I)

摘要翻译： 选定的化合物对于预防和治疗诸如c-met介导的疾病和/或HGF介导的疾病的疾病是有效的。 本发明包括新化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的疾病或病症的药物组合物和方法。本发明还涉及制备此类化合物的方法 关于在这样的过程中有用的中间体。 （一世）