公开(公告)号：EP2129395A2

公开(公告)日：2009-12-09

申请号：EP08799657.5

申请日：2008-03-27

申请人： The Regents of the University of California ,  Duke University ,  THE UNIVERSITY OF ALABAMA AT BIRMINGHAM ,  UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： HAYNES, Barton, F. ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  BHATTACHARYA, Tanmoy ,  GNANAKARAN, Gnana, S. ,  GAO, Feng ,  SWANSTROM, Ron ,  SHAW, George

IPC分类号： A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a method of inducing an immune response to HIV in a patient and to immunogens suitable for use in such a method. The invention also relates to diagnostic test kits and methods of using same.

公开(公告)号：EP4214237A1

公开(公告)日：2023-07-26

申请号：EP21870168.8

申请日：2021-09-15

申请人： Duke University ,  Walters, Lucy, C. ,  Gillespie, Geraldine ,  Brackenridge, Simon ,  McMichael, Andrew, James ,  Saunders, Kevin, O.

发明人： HAYNES, Barton, F. ,  LI, Dapeng ,  AZOITEI, Mihai ,  WALTERS, Lucy, C. ,  GILLESPIE, Geraldine ,  BRACKENRIDGE, Simon ,  MCMICHAEL, Andrew, James ,  SAUNDERS, Kevin, O.

IPC分类号： C07K16/28 ,  A61K39/395 ,  C07K14/705 ,  C12P21/02

公开(公告)号：EP3519428A1

公开(公告)日：2019-08-07

申请号：EP17859028.7

申请日：2017-10-03

申请人： Duke University

发明人： HAYNES, Barton, F. ,  WIEHE, Kevin, J. ,  BONSIGNORI, Mattia

IPC分类号： C07K14/16 ,  A61K39/00

公开(公告)号：EP2707388B1

公开(公告)日：2019-06-12

申请号：EP12782672.5

申请日：2012-03-23

申请人： Duke University ,  The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： MASCOLA, John, R. ,  NABEL, Gary ,  HAYNES, Barton, F. ,  WU, Xueling ,  KEPLER, Thomas, B. ,  KWONG, Peter

IPC分类号： C07K16/10 ,  C12N15/13 ,  A61K39/42 ,  A61P31/18

公开(公告)号：EP2739312B1

公开(公告)日：2017-10-04

申请号：EP12819608.6

申请日：2012-08-03

申请人： Children's Medical Center Corporation ,  Duke University

发明人： WHITTLE, James ,  HARRISON, Stephen, C. ,  HAYNES, Barton, F. ,  LIAO, Hua-xin ,  MOODY, M., Anthony ,  KEPLER, Thomas, B. ,  SCHMIDT, Aaron, G

IPC分类号： C07K16/10 ,  A61P31/16 ,  A61K38/02

CPC分类号： C07K16/1018 ,  A61K31/713 ,  A61K38/02 ,  A61K47/6841 ,  A61K51/1006 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76

公开(公告)号：EP2981545A1

公开(公告)日：2016-02-10

申请号：EP14779212.1

申请日：2014-04-01

申请人： Duke University

发明人： HAYNES, Barton, F. ,  LIAO, Hua-xin ,  YU, Jae-sung

IPC分类号： C07K14/155

CPC分类号： C07K14/005 ,  C12N7/00 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to HIV-1 and, in particular, to methods of producing HIV- 1 envelope (Env) proteins, and subunits thereof, and to constructs suitable for use in such methods.

摘要翻译： 本发明一般涉及HIV-1，特别涉及生产HIV-1包膜蛋白（Env）蛋白及其亚基的方法，以及适用于此类方法的构建体。

公开(公告)号：EP2912055A1

公开(公告)日：2015-09-02

申请号：EP13848800.2

申请日：2013-10-28

申请人： Duke University ,  Sloan Kettering Institute For Cancer Research ,  Dana-Farber Cancer Institute, Inc.

发明人： HAYNES, Barton, F. ,  LIAO, Hua-xin ,  ALAM, S., Munir ,  DANISHEFSKY, Samuel ,  AUSSEDAT, Baptiste ,  PARK, Peter, K. ,  VOHRA, Yusuf ,  SODROSKI, Joseph

IPC分类号： C07K14/155 ,  C07K16/10

CPC分类号： A61K39/21 ,  A61K39/12 ,  C07K14/005 ,  C07K16/1063 ,  C07K2317/34 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus- ! (HIV- 1), and, in particular to a vaccine for HiV-l and to methods of making and using same. The present invention provides synthetic glycosylated HIV-1 peptides, method for their preparation and use.

公开(公告)号：EP2694533A2

公开(公告)日：2014-02-12

申请号：EP12768170.8

申请日：2012-04-09

申请人： Duke University

发明人： SPICER, Leonard, D. ,  REARDON, Patrick, N. ,  HAYNES, Barton, F. ,  ALAM, S., Munir

IPC分类号： C07K14/16 ,  A61K39/21 ,  A61K47/42

CPC分类号： A61K39/21 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/127 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55572 ,  C07K16/1045 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/21 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.

公开(公告)号：EP2477658A2

公开(公告)日：2012-07-25

申请号：EP10817555.5

申请日：2010-09-16

申请人： Duke University ,  The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Feinstein Institute for Medical Research

发明人： HAYNES, Barton, F. ,  TOMARAS, Georgia ,  SHEN, Shaunna ,  DIMITROV, Dimiter, S. ,  ZHU, Zhongyu ,  HWANG, Kwan-Ki ,  CHIORAZZI, Nicholas

IPC分类号： A61K39/42 ,  C07K16/10 ,  C12N5/07 ,  A61P31/18

CPC分类号： C07K16/1063 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76

摘要： The present invention relates, in general, to HIV-1 specific antibodies and, in particular, to broadly neutralizing HIV-1 specific antibodies that target the gp41 membrane-proximal external region (MPER). The present invention also relates to a cell culture system, more specifically, to a method of rendering chronic lymphocytic leukemia B-cells immortal and to a method of isolating anti-viral antibodies from clones of such cells.

公开(公告)号：EP2413905A2

公开(公告)日：2012-02-08

申请号：EP10759167.9

申请日：2010-04-05

申请人： Duke University ,  Children's Medical Center Corporation

发明人： ALAM, Munir ,  HAYNES, Barton, F. ,  HARRISON, Stephen ,  CHEN, Bing

IPC分类号： A61K9/127 ,  A61K39/395 ,  A61P31/18 ,  A61P31/12

CPC分类号： A61K9/127 ,  A61K39/12 ,  A61K39/21 ,  A61K47/62 ,  A61K47/6911 ,  A61K2039/55511 ,  A61K2039/55522 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2740/16134