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21.发明授权
公开(公告)号：EP1311504B1
公开(公告)日：2005-06-15
申请号：EP01962926.0
申请日：2001-08-09
发明人： SIDDURI, Achyutharao
IPC分类号： C07D417/12 , C07D401/12 , C07D257/04 , A61K31/41 , A61K31/427 , A61K31/4427 , A61P3/10
CPC分类号： C07D257/04 , C07D401/12 , C07D417/12
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公开(公告)号：EP1311504A1
公开(公告)日：2003-05-21
申请号：EP01962926.0
申请日：2001-08-09
发明人： SIDDURI, Achyutharao
IPC分类号： C07D417/12 , C07D401/12 , C07D257/04 , A61K31/41 , A61K31/427 , A61K31/4427 , A61P3/10
CPC分类号： C07D257/04 , C07D401/12 , C07D417/12
摘要： Tetrazotyl-phenyl acetamides of formula (1) wherein Z is (2) one of R1 or R2 is (3) and the other is hydrogen, halogen, lower alkyl sulfonyl, perfluoro lower alkyl, cyano, or nitro; R3 is cycloalkyl; R4 is -C(O)-NHR6 or a five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amide group, are active as glucokinase activators, and are able to increase insulin secretion, which makes them useful for treating type II diabetes.
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公开(公告)号：EP1242397A1
公开(公告)日：2002-09-25
申请号：EP00987392.8
申请日：2000-12-12
IPC分类号： C07D277/46 , A61K31/426 , C07D213/75 , C07D277/56 , C07C275/50 , A61K31/4402 , A61K31/44 , A61K31/17 , A61P3/10
CPC分类号： C07D213/75 , C07C275/50 , C07C317/44 , C07C2601/08 , C07C2601/14 , C07D277/46
摘要： 2,3-Di-substituted trans olefinic N-heteroaromatic or urido proprionamides of formula (I) with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said proprionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
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