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公开(公告)号：EP2066319B1
公开(公告)日：2012-02-01
申请号：EP07803049.1
申请日：2007-08-30
发明人： GOLDSTEIN, David Michael , GONG, Leyi , MICHOUD, Christophe , PALMER, Wylie Solang , SIDDURI, Achyutharao
IPC分类号： A61K31/4192 , A61K31/506 , A61P35/00 , A61P37/00 , C07D403/04 , C07D403/14
CPC分类号： C07D403/04 , C07D403/14
摘要： The invention is concerned with novel benzotriazole derivatives of Formula (I) Wherein R, R1, R2, R3, and m are as defined in the description and the claims, as well as physiologically acceptable salts thereof. These compounds are JNK and CDK modulators.
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公开(公告)号：EP2234995A1
公开(公告)日：2010-10-06
申请号：EP08862307.9
申请日：2008-12-09
发明人： DOMINIQUE, Romyr , GOODNOW, Robert, Alan, Jr. , KOWALCZYK, Agnieszka , QIAO, Qi , SIDDURI, Achyutharao , TILLEY, Jefferson Wright
IPC分类号： C07D317/60 , C07D319/18 , C07C233/66 , C07C233/67 , C07C235/46 , A61K31/166
CPC分类号： C07D319/18 , C07C233/66 , C07C233/67 , C07C235/46 , C07D317/60
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.
摘要翻译： 本文提供了式（I）化合物：及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如例如COPD的疾病。
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公开(公告)号：EP1244625A1
公开(公告)日：2002-10-02
申请号：EP00985117.1
申请日：2000-11-29
IPC分类号： C07D213/64 , A61P29/00
CPC分类号： C07D213/64
摘要： Compounds of Formula (I) are disclosed wherein R1-R7 are as defined in the application and which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and, therefore, are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4, such as chronic inflammatory diseases.
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4.发明授权INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING LFA-1 有权整合素拮抗剂共轭物用于靶向递送至表达LFA-1的细胞
公开(公告)号：EP2806897B1
公开(公告)日：2017-08-02
申请号：EP13701434.6
申请日：2013-01-24
发明人： GOODNOW JR., Robert Alan , HAMILTON, Matthew Michael , KOWALCZYK, Agnieszka , SIDDURI, Achyutharao
IPC分类号： A61K47/54 , A61K47/60 , C07D207/36 , C07D207/46 , C07D213/71 , C07D403/12 , C07H21/02 , A61P35/00 , A61P29/00
CPC分类号： C07D403/12 , A61K47/54 , A61K47/545 , A61K47/60 , C07C327/06 , C07C381/00 , C07D207/36 , C07D207/46 , C07D213/71 , C07H21/02
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公开(公告)号：EP2763990B1
公开(公告)日：2017-02-22
申请号：EP12761923.7
申请日：2012-08-27
发明人： CHEN, Shaoqing , DE VICENTE FIDALGO, Javier , HAMILTON, Matthew Michael , HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LI, Hongju , LOVEY, Allen John , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , LYNCH, Stephen M. , O'YANG, Counde , PADILLA, Fernando , SCHOENFELD, Ryan Craig , SIDDURI, Achyutharao , SOTH, Michael , WANG, Ce , WOVKULICH, Peter Michael , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/5025 , A61P29/00
CPC分类号： C07D487/04
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6.发明授权NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权NAPHTHYRIDINONDERIVATE和它们在治疗，减轻或预防疾病病毒的
公开(公告)号：EP2945945B1
公开(公告)日：2016-08-31
申请号：EP14703780.8
申请日：2014-01-07
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , BUSCHMANN, Helmut , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau , HAWLEY, Ronald Charles , SIDDURI, Achyutharao
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/12
CPC分类号： A61K31/519 , A61K31/4375 , A61K31/4985 , A61K31/513 , A61K45/06 , C07D401/04 , C07D471/02 , C07D471/04
摘要： The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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公开(公告)号：EP2066319A1
公开(公告)日：2009-06-10
申请号：EP07803049.1
申请日：2007-08-30
发明人： GOLDSTEIN, David Michael , GONG, Leyi , MICHOUD, Christophe , PALMER, Wylie Solang , SIDDURI, Achyutharao
IPC分类号： A61K31/4192 , A61K31/506 , A61P35/00 , A61P37/00 , C07D403/04 , C07D403/14
CPC分类号： C07D403/04 , C07D403/14
摘要： The invention is concerned with novel benzotriazole derivatives of Formula (I) Wherein R, R1, R2, R3, and m are as defined in the description and the claims, as well as physiologically acceptable salts thereof. These compounds are JNK and CDK modulators.
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公开(公告)号：EP1237878A2
公开(公告)日：2002-09-11
申请号：EP00989906.3
申请日：2000-11-28
IPC分类号： C07D239/06 , A61K31/505 , A61P1/04 , A61P19/02
CPC分类号： C07D239/54 , A61K38/00 , C07K5/06165
摘要： Coumpounds of Formula (I) are disclosed, wherein R1 to R6 are as defined in specification and which are inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
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公开(公告)号：EP2806898B1
公开(公告)日：2018-07-18
申请号：EP13701435.3
申请日：2013-01-24
CPC分类号： A61K47/545 , A61K47/54 , A61K47/60
摘要： The invention relates to compounds of formula I: wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula I for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to VLA-4 integrin antagonists to target cells expressing VLA-4.
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10.发明公开NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权NAPHTHYRIDINONDERIVATE和它们在治疗，减轻或预防疾病病毒的
公开(公告)号：EP2945945A1
公开(公告)日：2015-11-25
申请号：EP14703780.8
申请日：2014-01-07
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , BUSCHMANN, Helmut , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau , HAWLEY, Ronald Charles , SIDDURI, Achyutharao
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/12
CPC分类号： A61K31/519 , A61K31/4375 , A61K31/4985 , A61K31/513 , A61K45/06 , C07D401/04 , C07D471/02 , C07D471/04
摘要： The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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