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21.发明公开
公开(公告)号：EP3825420A1
公开(公告)日：2021-05-26
申请号：EP20198766.6
申请日：2014-05-29
申请人： Genomic Health, Inc.
发明人： SHAK, Steven , WATSON, George Andrew , CRAGER, Michael R. , MADDALA, Tara , LOPATIN, Margarita , GODDARD, Audrey , KNEZEVIC, Dejan , SVEDMAN, Christer
IPC分类号： C12Q1/6886 , G16H50/30 , G16C99/00
摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.
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22.发明授权
公开(公告)号：EP3004392B1
公开(公告)日：2020-09-30
申请号：EP14804772.3
申请日：2014-05-29
申请人： Genomic Health, Inc.
发明人： SHAK, Steven , WATSON, George Andrew , CRAGER, Michael R. , MADDALA, Tara , LOPATIN, Margarita , GODDARD, Audrey , KNEZEVIC, Dejan , SVEDMAN, Christer
IPC分类号： C12Q1/6886
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公开(公告)号：EP3580357A1
公开(公告)日：2019-12-18
申请号：EP18707504.9
申请日：2018-02-12
申请人： Genomic Health, Inc.
发明人： LU, Ruixiao , CRAGER, Michael , ZHANG, Nan , MADDALA, Tara , FEBBO, Phillip , LAWRENCE, Hugh Jeffrey
IPC分类号： C12Q1/6809 , C12Q1/6886
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24.发明公开
公开(公告)号：EP3561078A1
公开(公告)日：2019-10-30
申请号：EP19173150.4
申请日：2011-01-07
申请人： Genomic Health, Inc.
发明人： SHAK, Steven , GODDARD, Audrey , KNEZEVIC, Dejan , BAKER, Joffre B. , KIEFER, Michael C. , MADDALA, Tara , BAEHNER, Frederick L. , COWENS, Wayne
IPC分类号： C12Q1/6886
摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma. In particular, NOS3 RNA expression level negatively correlates to with lower likelihood of recurrence, tumor grade / stage, presence of necrosis and nodal status in clear cell renal cell carcinoma (cc-RCC).
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25.发明公开METHOD TO USE GENE EXPRESSION TO DETERMINE LIKELIHOOD OF CLINICAL OUTCOME OF RENAL CANCER 审中-公开利用基因表达的抑制，用于确定肾癌的临床开发的可能性的方法
公开(公告)号：EP2524055A2
公开(公告)日：2012-11-21
申请号：EP11732245.3
申请日：2011-01-07
申请人： Genomic Health, Inc.
发明人： COWENS, Wayne , SHAK, Steven , GODDARD, Audrey , KNEZEVIC, Dejan , BAKER, Joffre , KIEFER, Michael C. , MADDALA, Tara , BAEHNER, Frederick L.
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57438 , G06F19/00 , G06F19/10 , G06N7/005 , G16H50/20
摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
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