公开(公告)号：EP3029155A2

公开(公告)日：2016-06-08

申请号：EP15203193.6

申请日：2011-01-07

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  BAKER, Joffre ,  KIEFER, Michael C. ,  MADDALA, Tara ,  BAEHNER, Frederick L. ,  COWENS, Wayne

IPC分类号： C12Q1/68 ,  C40B40/08 ,  G06F17/00 ,  G06F19/00

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57438 ,  G06F19/00 ,  G06F19/10 ,  G06N7/005 ,  G16H50/20

摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.

公开(公告)号：EP2598659A2

公开(公告)日：2013-06-05

申请号：EP11813024.4

申请日：2011-07-25

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  BAEHNER, Frederick, L. ,  MADDALA, Tara ,  LEE, Mark ,  PELHAM, Robert, J. ,  COWENS, Wayne ,  CHERBAVAZ, Diana ,  KIEFER, Michael, C. ,  CRAGER, Michael ,  GODDARD, Audrey ,  BAKER, Joffre, B.

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/00

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：EP3178944A3

公开(公告)日：2017-09-13

申请号：EP17153152.8

申请日：2011-01-07

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  BAKER, Joffre ,  KIEFER, Michael C. ,  MADDALA, Tara ,  BAEHNER, Frederick L. ,  COWENS, Wayne

IPC分类号： C12Q1/68 ,  C40B40/08 ,  G06F17/00 ,  G06F19/00

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57438 ,  G06F19/00 ,  G06F19/10 ,  G06N7/005 ,  G16H50/20

摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.

公开(公告)号：EP3004392A1

公开(公告)日：2016-04-13

申请号：EP14804772.3

申请日：2014-05-29

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  WATSON, George Andrew ,  CRAGER, Michael R. ,  MADDALA, Tara ,  LOPATIN, Margarita ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  SVEDMAN, Christer

IPC分类号： C12Q1/68

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

摘要翻译： 本发明提供基于算法的分子测定法，其涉及测量从肾癌患者获得的生物样品的基因的表达水平。 本发明还提供了基于从肾癌患者获得的生物样品的基因的表达水平的测量来获得患有肾癌的患者的定量评分的方法。 这些基因可以分为功能基因子集，用于计算定量分数，并且可以根据其对癌症复发的贡献来加权基因亚群。

公开(公告)号：EP3831964A2

公开(公告)日：2021-06-09

申请号：EP20210111.9

申请日：2011-01-07

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  BAKER, Joffre B. ,  KIEFER, Michael C. ,  MADDALA, Tara ,  BAEHNER, Frederick L. ,  COWENS, Wayne

IPC分类号： C12Q1/6886

摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification (e.g. determining the grade or stage of the tumor, or determining the presence of necrosis or nodal invasion) and/or prognosis (e.g. of recurrence) of cancer, in particular of renal cell carcinoma.

公开(公告)号：EP3147373A1

公开(公告)日：2017-03-29

申请号：EP16195347.6

申请日：2011-07-25

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  BAEHNER, Frederick L. ,  MADDALA, Tara ,  LEE, Mark ,  PELHAM, Robert ,  COWENS, Wayne ,  CHERBAVAZ, Diana ,  KIEFER, Michael C. ,  CRAGER, Michael ,  GODDARD, Audrey ,  BAKER, Joffre B.

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/00

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

摘要翻译： 分子检测确实涉及从前列腺癌患者获得的生物样品的生物标记物的预后，或共同过表达的生物标志物的表达水平的测量，并且所测量的表达水平的分析，以提供关于信息用于所述患者的可能的预后，和似然确实 所述患者将有前列腺癌的复发，或至肿瘤通过临床结果或融合TMPRSS2状态的似然性，在提供分类。

公开(公告)号：EP2598659B1

公开(公告)日：2015-03-11

申请号：EP11813024.4

申请日：2011-07-25

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  BAEHNER, Frederick, L. ,  MADDALA, Tara ,  LEE, Mark ,  PELHAM, Robert, J. ,  COWENS, Wayne ,  CHERBAVAZ, Diana ,  KIEFER, Michael, C. ,  CRAGER, Michael ,  GODDARD, Audrey ,  BAKER, Joffre, B.

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/00

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：EP3825420A1

公开(公告)日：2021-05-26

申请号：EP20198766.6

申请日：2014-05-29

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  WATSON, George Andrew ,  CRAGER, Michael R. ,  MADDALA, Tara ,  LOPATIN, Margarita ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  SVEDMAN, Christer

IPC分类号： C12Q1/6886 ,  G16H50/30 ,  G16C99/00

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

公开(公告)号：EP3004392B1

公开(公告)日：2020-09-30

申请号：EP14804772.3

申请日：2014-05-29

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  WATSON, George Andrew ,  CRAGER, Michael R. ,  MADDALA, Tara ,  LOPATIN, Margarita ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  SVEDMAN, Christer

IPC分类号： C12Q1/6886

公开(公告)号：EP3561078A1

公开(公告)日：2019-10-30

申请号：EP19173150.4

申请日：2011-01-07

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  BAKER, Joffre B. ,  KIEFER, Michael C. ,  MADDALA, Tara ,  BAEHNER, Frederick L. ,  COWENS, Wayne

IPC分类号： C12Q1/6886

摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma. In particular, NOS3 RNA expression level negatively correlates to with lower likelihood of recurrence, tumor grade / stage, presence of necrosis and nodal status in clear cell renal cell carcinoma (cc-RCC).