公开(公告)号：EP3004392A1

公开(公告)日：2016-04-13

申请号：EP14804772.3

申请日：2014-05-29

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  WATSON, George Andrew ,  CRAGER, Michael R. ,  MADDALA, Tara ,  LOPATIN, Margarita ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  SVEDMAN, Christer

IPC分类号： C12Q1/68

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

摘要翻译： 本发明提供基于算法的分子测定法，其涉及测量从肾癌患者获得的生物样品的基因的表达水平。 本发明还提供了基于从肾癌患者获得的生物样品的基因的表达水平的测量来获得患有肾癌的患者的定量评分的方法。 这些基因可以分为功能基因子集，用于计算定量分数，并且可以根据其对癌症复发的贡献来加权基因亚群。

公开(公告)号：EP3825420A1

公开(公告)日：2021-05-26

申请号：EP20198766.6

申请日：2014-05-29

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  WATSON, George Andrew ,  CRAGER, Michael R. ,  MADDALA, Tara ,  LOPATIN, Margarita ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  SVEDMAN, Christer

IPC分类号： C12Q1/6886 ,  G16H50/30 ,  G16C99/00

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

公开(公告)号：EP3004392B1

公开(公告)日：2020-09-30

申请号：EP14804772.3

申请日：2014-05-29

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  WATSON, George Andrew ,  CRAGER, Michael R. ,  MADDALA, Tara ,  LOPATIN, Margarita ,  GODDARD, Audrey ,  KNEZEVIC, Dejan ,  SVEDMAN, Christer

IPC分类号： C12Q1/6886

公开(公告)号：EP3063689A1

公开(公告)日：2016-09-07

申请号：EP14858957.5

申请日：2014-10-28

申请人： Genomic Health, Inc.

发明人： KIEFER, Michael C. ,  BAKER, Joffre B. ,  CRAGER, Michael R. ,  SEGAL, Mark R. ,  COLLIN, Francois ,  LEVY, Samuel

IPC分类号： G06F19/26

CPC分类号： G06F19/18 ,  C12Q1/6886 ,  C12Q2600/158 ,  G06F19/20 ,  G06F19/22 ,  G06F19/26

摘要： The present invention provides methods for incorporating transcript chromosomal locus information for identification of biomarkers of disease recurrence risk.