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40 条记录 (耗时 0.022 秒)

    Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof
    23.
    发明公开
    Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof 失效
    引发冯·3-吡咯烷基苯丙酮和Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0150235A1

    公开(公告)日：1985-08-07

    申请号：EP84100827.9

    申请日：1984-01-26

    申请人： Hokuriku Pharmaceutical Co.,Ltd

    发明人： Itho, Yasuo ,  Kato, Hideo ,  Ogawa, Nobuo ,  Koshinaka, Eiichi ,  Nishino, Hiroyuki

    IPC分类号： C07D295/10

    CPC分类号： C07D295/108

    摘要： Derivatives of 3-pyrrolidinopropiophenone of the formula (I)
    wherein R is an ethyl-, propyl-, isopropyl-, butyl-, isobutylgroup or a cycloalkyl-group having 5 to 7 carbon atoms, and the pharmaceutically acceptable acid addition salts thereof, exhibit a potent activity on muscle relaxation. Furtheron a process for the preparation of these compounds is disclosed.

    摘要翻译： 式（I）... 的3-吡咯烷基苯丙酮酮的衍生物，其中R是具有5-7个碳原子的乙基，丙基，异丙基，丁基，异丁基或环烷基， 其可接受的酸加成盐显示出对肌肉松弛的有效活性。 公开了制备这些化合物的方法。

    Pharmaceutical composition comprising calcium polycarbophil
    26.
    发明公开
    Pharmaceutical composition comprising calcium polycarbophil 失效
    聚卡泊芬 - 卡尔扎伊（Polycarbophil-Kalzium）参与了Arzneimittel。

    公开(公告)号：EP0488139A1

    公开(公告)日：1992-06-03

    申请号：EP91120102.8

    申请日：1991-11-26

    申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

    发明人： Ito, Yasuo ,  Kato, Hideo ,  Nagata, Osamu ,  Yamazaki, Masahiro ,  Ishibashi, Takeo ,  Kitayama, Masakazu

    IPC分类号： A61K31/78 ,  A61K9/20

    CPC分类号： A61K31/78 ,  A61K9/1652 ,  A61K9/2054 ,  Y10S514/867

    摘要： A pharmceutical composition capable of being disintegrated in an acidic environment, which comprises calcium polycarbophil and 1 to 80 % by weight of a cellulose derivative such as carboxymethylcellulose or low substituted hydroxypropylcellulose based on the calcium polycarbophil. The pharmaceutical composition in a form of a tablet, a capsule, or granules is useful as a bulk-forming laxative or an antidiarrheic agent since it can be disintegrated readily in the stomach and form a complete dispersion of polycarbophil in the digestive tract.

    摘要翻译： 能够在酸性环境中分解的药物组合物，其包含聚卡波非钙和1至80重量％的纤维素衍生物，例如基于聚卡必普的羧甲基纤维素或低取代的羟丙基纤维素。 片剂，胶囊或颗粒形式的药物组合物可用作体积形成泻药或止泻药，因为其可以在胃中容易地分解并形成聚卡泊芬在消化道中的完全分散体。

    Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same
    27.
    发明公开
    Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same 失效
    XANTHINE化合物，其制备方法和包含其的药物组合物

    公开(公告)号：EP0430025A3

    公开(公告)日：1992-05-06

    申请号：EP90122146.5

    申请日：1990-11-20

    申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

    发明人： Ito, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Yagi, Noriyuki ,  Iwasaki, Nobuhiko

    IPC分类号： C07D473/06 ,  A61K31/52

    CPC分类号： C07D473/04

    摘要： A novel xanthine compound having bronchodilating and brain function improving activity represented by the following formula (I) and (II):

    wherein R¹ represents a hydrogen atom, 4-methoxybenzyl group, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; R² represents a hydrogen atom, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; n represents an integer of from 1 to 4; and A represents -COCH₃ or - C(OR³)(OR⁴)CH₃ in which R³ and R⁴ independently represents an alkyl group having 1 to 3 carbon atoms or R³ together with R⁴ represents a polymethylene group having 2 to 4 carbon atoms is disclosed. Also disclosed are a pharmacologically acceptable salt of the same, method for preparing the same, and a pharmaceutical composition for the treatment of respiratory tract disease or brain disfunction comprising the effective amount of same.

    摘要翻译： 具有由下式（I）和（II）表示的支气管扩张和脑功能改善活性的新颖的黄嘌呤化合物：其中R 1表示氢原子，4-甲氧基苄基，直链或支链烷基 具有1至6个碳原子的基团或具有3至6个碳原子的环烷基; R 2表示氢原子，具有1〜6个碳原子的直链或支链烷基或具有3〜6个碳原子的环烷基; n表示1〜4的整数， 和A表示-COCH 3或-C（OR 3）（OR 4））CH 3，其中R 3和R 4独立地表示具有1至3个碳原子的烷基或R 3与 R 4表示碳原子数2〜4的多亚甲基。 还公开了其药学上可接受的盐，其制备方法和用于治疗呼吸道疾病或脑功能障碍的药物组合物，其包含其有效量。

    Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same
    29.
    发明公开
    Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效
    哌啶衍生物，其制备方法和药物组合物。

    公开(公告)号：EP0406739A2

    公开(公告)日：1991-01-09

    申请号：EP90112533.6

    申请日：1990-06-30

    申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

    发明人： Itoh, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

    IPC分类号： C07D211/70 ,  C07D405/04 ,  A61K31/445

    CPC分类号： C07D405/04 ,  C07D211/70

    摘要： A piperidine derivative represented by the following general formula (I):

    wherein R represents a hydrogen atom or a lower alkyl group; X represent -CH=CH-, -CH₂CH₂-, or -CH₂O-; Y represent an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents and alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

    摘要翻译： 由下述通式（I）表示的哌啶衍生物： worinřdarstellt一个氢原子或一个低级烷基; X代表-CH = CH-，-CH 2 CH 2，或-CH 2 O-; Y为具有在其可以任选被低级烷基，或Y darstellt substituiertem到-AOB-组worin A和B是相同的或不同的，并且具有1至3各自unabhängigdarstellt和亚烷基基团含1-5个碳原子的亚烷基团 这可能与低级烷基，任选地substituiertem碳原子是游离缺失盘。 所以游离缺失盘是式（I）中，用于制备式（I）的化合物的方法，包括式（I）的化合物的化合物在抗组胺和抗过敏剂的药理学上可接受的盐，以及用于治疗的方法 通过施用式（I）的化合物的过敏性疾病的。