公开(公告)号：EP0399414B1

公开(公告)日：1994-09-21

申请号：EP90109534.9

申请日：1990-05-19

申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

发明人： Itoh, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Ogawa, Nobuo ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

IPC分类号： C07D211/46 ,  C07D211/54 ,  A61K31/445

CPC分类号： C07D211/54 ,  C07D211/46

公开(公告)号：EP0451772A1

公开(公告)日：1991-10-16

申请号：EP91105567.1

申请日：1991-04-09

申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

发明人： Ito, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Ogawa, Nobuo ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

IPC分类号： C07D409/04 ,  A61K31/445

CPC分类号： C07D409/04

摘要： Novel piperidine compounds represented by the following formula (I):

wherein Y represents an alkylene group having 1 to 7 carbon atoms; A is a group represented by formula I-a or formula I-b:

wherein X represents -CH₂-S- or -S-; and R represents a hydrogen atom or a lower alkyl group with a proviso that A is a group represented by formula I-a, or R represents a hydrogen atom with a proviso that A is a group represented by formula I-b and pharmacologically acceptable salts thereof are disclosed. Also disclosed are a method for preparing the same; a pharmaceutical composition comprising the same; an antiallergic agent and an agent for bronchial asthma comprising the same; and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.

摘要翻译： 由下式（I）代表的新的哌啶化合物：具有1至7个碳原子的亚烷基团的worinÿdarstellt; A是由式I-a或式表示的基团I-B： worin X darstellt -CH 2 -S-或-S-; 和R darstellt氢原子或附带条件的低级烷基做A是由式表示的基团I-A，或R darstellt氢原子附带条件没有A是由式I-b和药理学上可接受的其盐盘游离缺失表示的基团。 所以游离缺失盘是其制备方法; 一种药物组合物是相同的; 抗过敏剂和用于支气管哮喘，其包括相同的试剂; 以及用于治疗过敏性疾病的或支气管哮喘的方法，包括给予相同的步骤。

公开(公告)号：EP0399414A1

公开(公告)日：1990-11-28

申请号：EP90109534.9

申请日：1990-05-19

申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

发明人： Itoh, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Ogawa, Nobuo ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

IPC分类号： C07D211/46 ,  C07D211/54 ,  A61K31/445

CPC分类号： C07D211/54 ,  C07D211/46

摘要： A piperidine derivative represented by the following general formula (I):
wherein R₁ and R₂ are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R₃ represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

摘要翻译： 由下述通式（I）表示的哌啶衍生物： worin R1和R2是相同或不同，并且各自unabhängigdarstellt氢原子，卤原子，低级烷基，或低级烷氧基; R 3表示氢原子或低级烷基; X darstellt到氧原子或硫原子; 具有可任选被低级烷基，或Y darstellt substituiertem到-AOB-组worin A和B是相同的或不同的，并且具有1至3的亚烷基基团的每个unabhängigdarstellt 1至7个碳原子的亚烷基基团Y的darstellt 这可能与低级烷基，任选地substituiertem碳原子是游离缺失盘。 所以游离缺失盘是式（I）中，在抗组胺和抗过敏剂，其包含式（I）的化合物的化合物，的药理学上可接受的盐的药物组合物包含式（I）的化合物，和用于的治疗的方法 通过施用式（I）的化合物的过敏性疾病。

公开(公告)号：EP0406739A3

公开(公告)日：1992-02-26

申请号：EP90112533.6

申请日：1990-06-30

申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

发明人： Itoh, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

IPC分类号： C07D211/70 ,  C07D405/04 ,  A61K31/445

CPC分类号： C07D405/04 ,  C07D211/70

摘要： A piperidine derivative represented by the following general formula (I):

wherein R represents a hydrogen atom or a lower alkyl group; X represent -CH=CH-, -CH₂CH₂-, or -CH₂O-; Y represent an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents and alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

公开(公告)号：EP0306827A1

公开(公告)日：1989-03-15

申请号：EP88114257.4

申请日：1988-09-01

申请人： Hokuriku Pharmaceutical Co.,Ltd

发明人： Itoh, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Ogawa, Nobuo ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

IPC分类号： C07C233/77 ,  C07C255/50 ,  C07C311/15 ,  C07D295/08 ,  C07D317/68 ,  C07C231/00 ,  A61K31/165 ,  A61K31/18 ,  A61K31/33

CPC分类号： C07D295/088 ,  C07C255/00 ,  C07D317/68

摘要： Amide-compounds represented by the formula (I):
wherein R, represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino which can be substituted by lower alkyl, nitro, cyano, sulfamoyl which can be substituted by lower alkyl, R 2 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino, nitro, wherein R, and R 2 can be combined to form methylenedioxy, R 3 means hydrogen, lower alkyl, halogen, or amino, R 4 and R s may be the same or different and each represents lower alkyl or wherein R 4 . and R 5 may be combined together with nitrogen to form 1-pyrrolidinyl or piperidino, and pharmacologically-acceptable acid-addition salts thereof, which exhibit excellent effects in the activation of gastric motor function, a process for preparation pharmaceutical compositons thereof, as well as a method for the treatment of a subject suffering from an ailment associated with inadequate gastric motor function by administrating such a compound to the said subject, are all disclosed.

摘要翻译： 由式（I）表示的酰胺化合物： worin R1 darstellt氢，低级烷氧基，羟基，低级烷基，卤素，氨基可以通过低级烷基，硝基，氰基被substituiertem，氨磺酰基可以由低级烷基substituiertem ，R2 darstellt氢，低级烷氧基，羟基，低级烷基，卤素，氨基，硝基，worin R1和R2可以结合以形成亚甲二氧基，R 3指的是氢，低级烷基，卤素，或氨基，R4和R5可以是相同或 不同，并且各自darstellt低级烷基或worin R4和R5可以一起与氮结合而形成1-吡咯烷基或哌啶子基，以及它们的药理学上可接受的酸加成盐，其在胃运动功能的激活显示出优异的效果，对于处理 制备药物COMPOSITONS物，以及作为用于从在通过给予寻求给受试者。所述化合物与不足胃运动功能相关的疾病的受治疗者治疗的方法，是所有盘 游离缺失。

公开(公告)号：EP0306827B1

公开(公告)日：1991-09-04

申请号：EP88114257.4

申请日：1988-09-01

申请人： Hokuriku Pharmaceutical Co.,Ltd

发明人： Itoh, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Ogawa, Nobuo ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

IPC分类号： C07C233/77 ,  C07C255/50 ,  C07C311/15 ,  C07D295/08 ,  C07D317/68 ,  C07C231/00 ,  A61K31/165 ,  A61K31/18 ,  A61K31/33

CPC分类号： C07D295/088 ,  C07C255/00 ,  C07D317/68

公开(公告)号：EP0406739A2

公开(公告)日：1991-01-09

申请号：EP90112533.6

申请日：1990-06-30

申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

发明人： Itoh, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

IPC分类号： C07D211/70 ,  C07D405/04 ,  A61K31/445

CPC分类号： C07D405/04 ,  C07D211/70

摘要： A piperidine derivative represented by the following general formula (I):

wherein R represents a hydrogen atom or a lower alkyl group; X represent -CH=CH-, -CH₂CH₂-, or -CH₂O-; Y represent an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents and alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

摘要翻译： 由下述通式（I）表示的哌啶衍生物： worinřdarstellt一个氢原子或一个低级烷基; X代表-CH = CH-，-CH 2 CH 2，或-CH 2 O-; Y为具有在其可以任选被低级烷基，或Y darstellt substituiertem到-AOB-组worin A和B是相同的或不同的，并且具有1至3各自unabhängigdarstellt和亚烷基基团含1-5个碳原子的亚烷基团 这可能与低级烷基，任选地substituiertem碳原子是游离缺失盘。 所以游离缺失盘是式（I）中，用于制备式（I）的化合物的方法，包括式（I）的化合物的化合物在抗组胺和抗过敏剂的药理学上可接受的盐，以及用于治疗的方法 通过施用式（I）的化合物的过敏性疾病的。