-
1.发明公开Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效的哌啶衍生物，处理其制备以及含有该药物组合物。
公开(公告)号：EP0399414A1
公开(公告)日：1990-11-28
申请号：EP90109534.9
申请日：1990-05-19
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Nishino, Hiroyuki , Sakaguchi, Jun
IPC分类号： C07D211/46 , C07D211/54 , A61K31/445
CPC分类号： C07D211/54 , C07D211/46
摘要： A piperidine derivative represented by the following general formula (I):
wherein R₁ and R₂ are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R₃ represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).摘要翻译： 由下述通式（I）表示的哌啶衍生物：
worin R1和R2是相同或不同，并且各自unabhängigdarstellt氢原子，卤原子，低级烷基，或低级烷氧基; R 3表示氢原子或低级烷基; X darstellt到氧原子或硫原子; 具有可任选被低级烷基，或Y darstellt substituiertem到-AOB-组worin A和B是相同的或不同的，并且具有1至3的亚烷基基团的每个unabhängigdarstellt 1至7个碳原子的亚烷基基团Y的darstellt 这可能与低级烷基，任选地substituiertem碳原子是游离缺失盘。 所以游离缺失盘是式（I）中，在抗组胺和抗过敏剂，其包含式（I）的化合物的化合物，的药理学上可接受的盐的药物组合物包含式（I）的化合物，和用于的治疗的方法 通过施用式（I）的化合物的过敏性疾病。 -
2.发明授权Amide compounds, process for preparing the same, and composition for activating gastric motor function containing the same 失效酰胺化合物，其制备方法以及用于活化含有该组合物的气体电动机功能的组合物
公开(公告)号：EP0306827B1
公开(公告)日：1991-09-04
申请号：EP88114257.4
申请日：1988-09-01
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Nishino, Hiroyuki , Sakaguchi, Jun
IPC分类号： C07C233/77 , C07C255/50 , C07C311/15 , C07D295/08 , C07D317/68 , C07C231/00 , A61K31/165 , A61K31/18 , A61K31/33
CPC分类号： C07D295/088 , C07C255/00 , C07D317/68
-
3.发明公开
公开(公告)号：EP0406739A2
公开(公告)日：1991-01-09
申请号：EP90112533.6
申请日：1990-06-30
IPC分类号： C07D211/70 , C07D405/04 , A61K31/445
CPC分类号： C07D405/04 , C07D211/70
摘要： A piperidine derivative represented by the following general formula (I):
wherein R represents a hydrogen atom or a lower alkyl group; X represent -CH=CH-, -CH₂CH₂-, or -CH₂O-; Y represent an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents and alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).摘要翻译： 由下述通式（I）表示的哌啶衍生物：
worinřdarstellt一个氢原子或一个低级烷基; X代表-CH = CH-，-CH 2 CH 2，或-CH 2 O-; Y为具有在其可以任选被低级烷基，或Y darstellt substituiertem到-AOB-组worin A和B是相同的或不同的，并且具有1至3各自unabhängigdarstellt和亚烷基基团含1-5个碳原子的亚烷基团 这可能与低级烷基，任选地substituiertem碳原子是游离缺失盘。 所以游离缺失盘是式（I）中，用于制备式（I）的化合物的方法，包括式（I）的化合物的化合物在抗组胺和抗过敏剂的药理学上可接受的盐，以及用于治疗的方法 通过施用式（I）的化合物的过敏性疾病的。 -
4.发明授权Phenoxyethylamine derivatives, process for preparing the same, and composition for exhibiting excellent alpha-1-blocking activity containing the same 失效苯甲酰胺衍生物，其制备方法和用于展示含有其的优异的ALPHA-1阻断活性的组合物
公开(公告)号：EP0331943B1
公开(公告)日：1992-06-17
申请号：EP89102720.3
申请日：1989-02-17
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Mitani, Kazuya , Sakurai, Shunichiro
IPC分类号： C07C311/15 , A61K31/18 , C07D207/48 , C07D211/96 , C07D295/22 , A61K31/395
CPC分类号： C07D295/26 , C07C311/27
-
公开(公告)号：EP0180810B1
公开(公告)日：1988-08-03
申请号：EP85112977.5
申请日：1985-10-12
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Kurata, Sakae , Nishino, Hiroyuki , Yoshida, Toshihiko
IPC分类号： C07C121/75 , C07C121/66 , C07D295/08 , A61K31/275 , A61K31/445
CPC分类号： C07C255/00
-
6.发明授权A 6-fluoro-1,4-dihydro-4-oxo-7-substituted piperazinyl-quinoline-3-carboxylic acid derivative and the method for preparing the same 失效6-氟-1,4-二氢-4-氧代-7-取代的哌嗪基 - 喹啉-3-羧酸衍生物及其制备方法
公开(公告)号：EP0140116B1
公开(公告)日：1988-05-25
申请号：EP84111035.6
申请日：1984-09-15
发明人： Itoh, Yasuo , Kato, Hideo , Ogawa, Nobuo , Koshinaka, Eiichi , Suzuki, Tomio , Yagi, Noriyuki
IPC分类号： C07D401/04 , A61K31/47
CPC分类号： C07D215/56
-
7.发明公开Pyrazine derivative, a process for preparation thereof and pharmaceutical composition therefrom 失效的吡嗪衍生物，其制备方法以及含有它们的药物组合物的过程。
公开(公告)号：EP0227026A1
公开(公告)日：1987-07-01
申请号：EP86117566.9
申请日：1986-12-17
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Mitani, Kazuya
IPC分类号： C07D403/12 , A61K31/495
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14
摘要： Novel pyrazine derivatives useful for treatment of bronchial asthma, allergic gastroenteric trouble, hay fever urticaria, allergic rhinitis, allergic conjunctivitis are disclosed.
-
8.发明授权Propiophenone derivatives for treatment of pollakiuria (frequency urination) 失效尿频的治疗（频繁的冲动排尿）苯丙酮衍生物。
公开(公告)号：EP0273375B2
公开(公告)日：1995-05-10
申请号：EP87119084.9
申请日：1987-12-23
IPC分类号： A61K31/40 , A61K31/445 , A61K31/535 , A61K31/55
CPC分类号： A61K31/535 , A61K31/40 , A61K31/445 , A61K31/55 , Y10S514/906
-
9.发明公开
公开(公告)号：EP0406739A3
公开(公告)日：1992-02-26
申请号：EP90112533.6
申请日：1990-06-30
IPC分类号： C07D211/70 , C07D405/04 , A61K31/445
CPC分类号： C07D405/04 , C07D211/70
摘要： A piperidine derivative represented by the following general formula (I):
wherein R represents a hydrogen atom or a lower alkyl group; X represent -CH=CH-, -CH₂CH₂-, or -CH₂O-; Y represent an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents and alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).-
10.发明公开Propiophenone derivatives for treatment of pollakiuria (frequency urination) 失效用于治疗痤疮的普罗吩酮衍生物（频率排尿）
公开(公告)号：EP0273375A3
公开(公告)日：1990-05-16
申请号：EP87119084.9
申请日：1987-12-23
IPC分类号： A61K31/40 , A61K31/445 , A61K31/535 , A61K31/55
CPC分类号： A61K31/535 , A61K31/40 , A61K31/445 , A61K31/55 , Y10S514/906
摘要： The use of propiophenone derivatives of the general Formula (I)
is described,
wherein R₁, R₂ and R₃, which may be the same or different, each independently represents hydrogen, halogen, lower alkyl- or halogeno-lower-alkyl group having a straight or branched carbon chain, a lower-alkoxy group or a cycloalkyl group having 3-8 carbon atoms, two of which R₁, R₂, and R₃ groups may combine to form methylenedioxy or ethyleneoxy, R₄ represents hydrogen or a lower-alkyl group having a straight or branched carbon chain, and A represents pyrrolidinyl-, piperidinyl-, morpholinyl-, or azepinyl or a pharmaceutically acceptable acid addition salt thereof, for the manufacture of a medicament for treatment of frequency urination.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.013 秒)
