公开(公告)号：EP2996705B1

公开(公告)日：2018-08-01

申请号：EP14726547.4

申请日：2014-05-07

申请人： Indena S.p.A.

发明人： BOMBARDELLI, Ezio ,  MORAZZONI, Paolo

IPC分类号： A61K36/889 ,  A61K36/9068 ,  A61K36/28 ,  A61P13/08

CPC分类号： A61K36/9068 ,  A61K36/185 ,  A61K36/28 ,  A61K36/55 ,  A61K36/758 ,  A61K36/889 ,  A61K47/44 ,  A61K2236/00

摘要： Disclosed are compositions containing an extract of Serenoa repens, a lipophilic extract of Zingiber officinalis and a lipophilic extract of Echinacea angustifolia or Zanthoxylum bungeanum.

公开(公告)号：EP3010879B1

公开(公告)日：2017-08-02

申请号：EP14735872.5

申请日：2014-06-17

申请人： Indena S.p.A.

发明人： MORAZZONI, Paolo ,  RIVA, Antonella ,  FONTANA, Gabriele

IPC分类号： C07C45/67 ,  C07C49/757 ,  A61K31/122 ,  A61P25/28

CPC分类号： C07C49/757 ,  C07C45/673 ,  C07C2602/46

公开(公告)号：EP2262503B1

公开(公告)日：2014-04-30

申请号：EP09718874.2

申请日：2009-03-09

申请人： INDENA S.p.A.

发明人： BOMBARDELLI, Ezio ,  FONTANA, Gabriele ,  MORAZZONI, Paolo ,  RIVA, Antonella ,  RONCHI, Massimo

IPC分类号： A61K31/4741 ,  A61K36/75 ,  A61K36/66 ,  A61P17/00

CPC分类号： A61K36/66 ,  A61K31/4741 ,  A61K36/75 ,  Y10S514/863

公开(公告)号：EP2443142A1

公开(公告)日：2012-04-25

申请号：EP10728126.3

申请日：2010-06-16

申请人： Indena S.p.A.

发明人： MORAZZONI, Paolo ,  RIVA, Antonella ,  PONZONE, Cesare ,  BERLANDA, Davide ,  DURANTI, Marcello ,  CONSONNI, Alessandro

IPC分类号： C07K14/415

CPC分类号： C07K14/415

摘要： A truncated form of α' chain (eα'), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast Pichia pastoris. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha' subunit. The eα' polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.

公开(公告)号：EP2278971A1

公开(公告)日：2011-02-02

申请号：EP09735815.4

申请日：2009-04-06

申请人： Indena S.p.A.

发明人： BOMBARDELLI, Ezio ,  FONTANA, Gabriele ,  GIORI, Andrea ,  MORAZZONI, Paolo ,  RIVA, Antonella ,  RONCHI, Massimo

IPC分类号： A61K31/473 ,  A61K31/343

CPC分类号： A61K36/28 ,  A61K31/343 ,  A61K31/473 ,  A61K36/758 ,  A61K2300/00

摘要： The present invention relates to compositions comprising benzofuran compounds and benzophenanthridine alkaloids, which possess anti- inflammatory, antibacterial and antifungal activity useful in the treatment of vaginal infections and the resulting inflammatory states.

公开(公告)号：EP1907405A1

公开(公告)日：2008-04-09

申请号：EP06762703.4

申请日：2006-07-20

申请人： INDENA S.p.A.

发明人： FONTANA, Gabriele ,  BOMBARDELLI, Ezio ,  RIVA, Antonella ,  MORAZZONI, Paolo ,  POCAR, Donato Istituto di Chimica Organica ,  GELMI, Maria Luisa Istituto di Chimica Organica ,  PONTREMOLI, Guido Istituto di Chimica Organica

IPC分类号： C07H15/248 ,  A61K31/404 ,  A61K31/165 ,  A61P21/02 ,  A61P29/00 ,  C07C323/41

CPC分类号： C07H15/248

摘要： The present invention relates to 3-demethoxy-3-aminothiocolchicine glycosyl derivatives of general formula (I) in which R is hydrogen, methyl or hydroxymethyl. The compounds of formula (I) have myorelaxant and anti-inflammatory activity.

公开(公告)号：EP1503775B1

公开(公告)日：2006-03-08

申请号：EP03729955.9

申请日：2003-04-30

申请人： INDENA S.p.A.

发明人： BOMBARDELLI, Ezio ,  MORAZZONI, Paolo ,  RIVA, Antonella ,  SEGHIZZI, Roberto

IPC分类号： A61K36/54 ,  A61K36/16 ,  A61P15/00 ,  A61P15/10

CPC分类号： A61K36/16 ,  A61K31/197 ,  A61K31/215 ,  A61K36/185 ,  A61K36/54 ,  A61K2300/00

摘要： Disclosed are pharmaceutical compositions containing: extracts of Tribulus terrestris, Turnera diffusa and Cinnamon cassia in the weight ratio of 1.5-3.5 : 1-2 : 0.1-0.4 respectively; Ginkgo biloba extract, and optionally arginine or a physiologically equivalent esters salts or precursor thereof. The compositions according to the invention are useful in the treatment of male and female sexual dysfunctions.

公开(公告)号：EP1605957A1

公开(公告)日：2005-12-21

申请号：EP04708771.3

申请日：2004-02-06

申请人： INDENA S.p.A.

发明人： MORAZZONI, Paolo ,  DURANTI, Marcello

IPC分类号： A61K35/78 ,  A61P3/10

CPC分类号： A61K38/168 ,  A61K36/23 ,  A61K36/48

摘要： The present invention discloses the use of lupin conglutin gamma or of proteins showing homology higher than 50% with lupin conglutin gamma, for the preparation of a medicament, food supplements or foods for the treatment of type II diabetes, pharmaceutical and nutritional compositions containing lupin conglutin gamma, and the use of lupin conglutin gamma as therapeutical agent, in particular as hypoglycemizing agent. Lupin conglutin gamma may be used in pure form or in form of extracts, mixtures or concentrates.

公开(公告)号：EP1505997A1

公开(公告)日：2005-02-16

申请号：EP03749863.1

申请日：2003-05-02

申请人： INDENA S.p.A.

发明人： BOMBARDELLI, Ezio ,  MORAZZONI, Paolo ,  RIVA, Antonella ,  SEGHIZZI, Roberto

IPC分类号： A61K35/78 ,  A61P15/00

CPC分类号： A61K31/198 ,  A61K31/11 ,  A61K31/192 ,  A61K31/70 ,  A61K36/185 ,  A61K36/296 ,  A61K36/54 ,  A61K2300/00

摘要： Pharmaceutical compositions containing: ▪ extracts of Tribulus terrestris, Epimedium koreanum, Cinnamon cassia in the weight ratio of 1.5-3.5 : 1-2 : 0.1-0.4 respectively; and optionally ▪ arginine or a physiologically equivalent ester, salt or precursor thereof. The compositions of the invention are useful in the treatment of male and female sexual dysfunctions.

公开(公告)号：EP1181030A2

公开(公告)日：2002-02-27

申请号：EP00940292.6

申请日：2000-05-31

申请人： INDENA S.p.A.

发明人： BOMBARDELLI, Ezio ,  MORAZZONI, Paolo

IPC分类号： A61K35/78

CPC分类号： A61K36/28 ,  A61K8/97 ,  A61Q19/00 ,  Y10S514/816 ,  Y10S514/885

摘要： Extracts of Tanacetum parthenium with a reduced content of α-unsaturated η-lactons, particularly of parthenolide, obtainable by elution on basic resins. The extracts of the invention have favourable pharmacological properties together with reduced risks of allergic reactions.