公开(公告)号：EP1565436B1

公开(公告)日：2012-04-25

申请号：EP03790120.4

申请日：2003-11-26

申请人： Incyte Corporation

发明人： XUE, Chu-Biao ,  METCALF, Brian ,  FENG, Hao ,  CAO, Ganfeng ,  HUANG, Taishing ,  ZHENG, Changsheng ,  ROBINSON, Darius, J. ,  HAN, Amy, Qi

IPC分类号： C07D207/14 ,  A61P37/02

CPC分类号： C07D491/107 ,  C07D207/14 ,  C07D401/08 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/08 ,  C07D403/10 ,  C07D405/04 ,  C07D405/08 ,  C07D405/10 ,  C07D405/14 ,  C07D409/08 ,  C07D413/08 ,  C07D413/10 ,  C07D413/14 ,  C07D417/08 ,  C07D417/10 ,  C07D417/14 ,  C07D491/10 ,  C07D495/10

摘要： The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

公开(公告)号：EP1763347A2

公开(公告)日：2007-03-21

申请号：EP05787815.9

申请日：2005-06-27

申请人： INCYTE CORPORATION

发明人： XUE, Chu-Biao ,  ZHENG, Changsheng ,  FENG, Hao ,  XIA, Michael ,  GLENN, Joseph ,  CAO, Ganfeng ,  METCALF, Brian, W.

IPC分类号： A61K31/4433 ,  A61K31/453 ,  A61K31/496 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D309/14 ,  C07D405/12 ,  C07D405/14

摘要： The present invention is directed to compounds of Formula (I) : which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.

公开(公告)号：EP1734966A2

公开(公告)日：2006-12-27

申请号：EP05755295.2

申请日：2005-04-12

申请人： INCYTE CORPORATION

发明人： XUE, Chu-Biao ,  CAO, Ganfeng ,  Huang, Taisheng ,  CHEN, Lihua ,  ZHANG, Ke ,  WANG, Anlai ,  MELONI, David ,  ANAND, Rajan ,  GLENN, Joseph ,  METCALF, Brian

IPC分类号： A61K31/495

CPC分类号： C07D401/14 ,  A61K31/496 ,  A61K31/502 ,  A61K31/506 ,  A61K45/06 ,  C07D401/06 ,  C07D417/14 ,  C07D471/04 ,  A61K2300/00

摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.