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    3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS
    1.
    发明公开
    3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS 有权
    3-环丙基氨基吡啶 - 衍生物ALS调节剂VON CHEMOKIN-REZEPTOREN

    公开(公告)号：EP1696919A2

    公开(公告)日：2006-09-06

    申请号：EP04814497.6

    申请日：2004-12-16

    申请人： INCYTE CORPORATION

    发明人： XUE, Chu-Biao ,  METCALF, Brian ,  HAN, Amy Qi ,  ROBINSON, Darius, J. ,  ZHENG, Changsheng ,  WANG, Anlai ,  ZHANG, Yingxin

    IPC分类号： A61K31/44 ,  C07D401/12 ,  C07D401/14

    CPC分类号： C07D277/24 ,  A61K31/4025 ,  A61K31/454 ,  C07D207/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula 1: (wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

    摘要翻译： （其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X，Y和Z如本文所定义），其可用作趋化因子受体活性的调节剂。 特别地，这些化合物可用作趋化因子受体的调节剂，更具体地可用作CCR2和/或CCR5受体的调节剂。 本发明的化合物和组合物可以结合趋化因子受体，例如CCR2和/或CCR5趋化因子受体，并且可用于治疗与趋化因子（例如CCR2和/或CCR5）相关的疾病，例如动脉粥样硬化，再狭窄， 狼疮，器官移植排斥和类风湿关节炎。