公开(公告)号：EP2188272A2

公开(公告)日：2010-05-26

申请号：EP08786967.3

申请日：2008-08-06

申请人： NV Remynd

发明人： GRIFFIOEN, Gerard ,  ROJAS DE LA PARRA, Veronica ,  LAUWERS, Annick

IPC分类号： C07D277/42 ,  C07D417/06 ,  C07D417/12 ,  C07D417/04 ,  A61K31/496 ,  A61P25/28

CPC分类号： C07D417/06 ,  C07D277/42 ,  C07D417/04 ,  C07D417/12

摘要： This invention provides phenyl- and benzyl-thiazolylpiperazine derivatives, and
N -sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease.

公开(公告)号：EP1981504A2

公开(公告)日：2008-10-22

申请号：EP07711455.1

申请日：2007-02-07

申请人： NV Remynd

发明人： GRIFFIOEN, Gerard ,  COUPET, Kristel Marie Edith ,  DUHAMEL, Hein Roger ,  WERA, Stefaan ,  GOMME, Ellen ,  VAN DAMME, Nele ,  VAN DER AUWERA, Ingrid ,  LOX, Marleen ,  VAN DOOREN, Tom ,  DECRUY, Tine

IPC分类号： A61K31/496 ,  C07D285/12 ,  C07C257/14 ,  A61P25/00

CPC分类号： C07C257/14 ,  A61K31/496 ,  C07D285/08 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12

摘要： This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease.

公开(公告)号：EP1644505A1

公开(公告)日：2006-04-12

申请号：EP04737685.0

申请日：2004-07-09

申请人： reMynd NV

发明人： GRIFFIOEN, Gerard ,  DUHAMEL, Hein ,  VAN DAMME, Nele ,  WINDERICKX, Joris ,  WERA, Stefaan

IPC分类号： C12N15/81 ,  C12N9/64 ,  C07K14/395 ,  C07K14/47 ,  G01N33/68

CPC分类号： C12N15/81 ,  C07K14/395

摘要： The present invention relates to an engineered yeast strain, comprising a transgene encoding one or more amyloidogenic proteins or mutant(s) thereof, characterised in that it lacks one or more functional genes responsive to oxidative stress. The invention further relates to the use of this yeast strain for pharmaceutical screening, for modelling of neurodegenerative diseases and for cellular modelling of biochemistry of the amyloidogenic proteins involved therein.