公开(公告)号：EP2138489A1

公开(公告)日：2009-12-30

申请号：EP08721875.6

申请日：2008-03-12

申请人： Kowa Company. Ltd.

发明人： OHGIYA, Tadaaki ,  MIURA, Toru ,  OKUDA, Ayumu ,  ARAI, Toshiharu ,  YAMAZAKI, Koichi ,  AOKI, Taro ,  MIYOSAWA, Katsutoshi ,  SHIBATA, Haruki ,  SHIBUYA, Kimiyuki

IPC分类号： C07D401/12 ,  A61K31/506 ,  A61P3/06 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D403/12 ,  C07D471/04

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D471/04

摘要： A compound represented by the following general formula (I), wherein R 1 , R 2 , R 3 , R 4 and R 5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R 6 represents an alkyl group, a cycloalkyl group and the like, R 7 and R 8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R 9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R 10 and R 11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

摘要翻译： 由以下通式（I）表示的化合物，其中R 1，R 2，R 3，R 4和R 5表示氢原子，卤素原子，低级烷基等，R 6表示烷基， 环烷基等，R 7和R 8表示氢原子，低级烷基，（低级环烷基）（低级烷基）等，R 9表示氢原子，卤素原子，低级烷氧基和 R 10和R 11表示氢原子，低级烷基，低级烷氧基，卤代（低级烷基）等，A表示由6〜10个原子构成的杂环，其具有强的抑制性 胆固醇酯转运蛋白（CETP）活性。

公开(公告)号：EP2000137A9

公开(公告)日：2009-03-18

申请号：EP07736973.4

申请日：2007-03-28

申请人： Kowa Company. Ltd. ,  Nissan Chemical Industries, Ltd.

发明人： YOKOYAMA, Toru ,  AOKI, Taro

IPC分类号： A61K31/47 ,  A61K31/4422 ,  A61P3/06 ,  A61P43/00 ,  C07D211/90 ,  C07D215/14

CPC分类号： C07D211/90 ,  A61K31/4422 ,  A61K31/47 ,  C07D215/14 ,  A61K2300/00

摘要： The present invention is directed to a triglyceride-lowering agent, exhibiting excellent triglyceride-lowering effect and a hyperinsulinemia-ameliorating agent.
The triglyceride-lowering agent and hyperinsulinemia-ameliorating agent are characterized by containing a pitavastatin compound, and amlodipine or a salt thereof.

公开(公告)号：EP1785137A1

公开(公告)日：2007-05-16

申请号：EP05777087.7

申请日：2005-08-30

申请人： Kowa Company. Ltd. ,  Nissan Chemical Industries, Ltd.

发明人： AOKI, Taro ,  YAMAZAKI, Hiroyuki ,  MAEJIMA, Takashi

IPC分类号： A61K31/47 ,  A61K31/397 ,  A61P3/06

CPC分类号： A61K31/397 ,  A61K31/47 ,  A61K31/4709 ,  A61K2300/00

摘要： Provided is a therapeutic agent for hyperlipemia or hypercholesterolemia, which comprises administering effective doses of ezetimibe and pitavastatin or a salt or lactone derivative thereof.

摘要翻译： 本发明提供高脂血症或高胆固醇血症的治疗剂，其包括施用有效剂量的依泽麦布和匹伐他汀或其盐或内酯衍生物。