-
公开(公告)号：EP3408289A1
公开(公告)日：2018-12-05
申请号：EP17701829.8
申请日：2017-01-20
IPC分类号： C07K16/18 , G01N33/574
CPC分类号： C07K16/18 , G01N33/6887 , G01N2800/12
摘要： A method of immunoassay for detecting in a biological sample a fragment of collagen type VII alpha 1 comprising an N- or C-terminal neo-epitope, the method comprising contacting the biological sample comprising the fragment of collagen type VII alpha 1 comprising the N- or C-terminal neo-epitope with an antibody of the invention, and determining the amount of binding of the antibody
-
公开(公告)号：EP2707495B1
公开(公告)日：2018-06-13
申请号：EP12720854.4
申请日：2012-05-04
CPC分类号： G01N33/6893 , C07K14/4725 , C07K16/18 , C07K2317/34 , C12Q1/37 , G01N33/6878 , G01N2800/32 , G01N2800/323
摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of mimecan, a protein of an atherosclerotic plaque, by a proteinase is provided. In the method a sample, such as urine or serum, is contacted with an antibody reactive with the neo-epitope and the level of binding of the antibody to peptide fragments in the sample is determined. The assay is predictive of risk of cardiovascular disease events.
-
公开(公告)号：EP4025915A1
公开(公告)日：2022-07-13
申请号：EP20767782.4
申请日：2020-09-03
-
公开(公告)号：EP3729096A1
公开(公告)日：2020-10-28
申请号：EP18829777.4
申请日：2018-12-13
IPC分类号： G01N33/574 , C07K16/18
-
公开(公告)号：EP3094979B1
公开(公告)日：2020-08-12
申请号：EP15701300.4
申请日：2015-01-08
-
公开(公告)号：EP3066475B1
公开(公告)日：2019-07-17
申请号：EP14783620.9
申请日：2014-10-10
发明人： KARSDAL, Morten , HENRIKSEN, Kim
IPC分类号： G01N33/68
-
公开(公告)号：EP3411716A1
公开(公告)日：2018-12-12
申请号：EP17703944.3
申请日：2017-02-02
发明人： GENOVESE, Federica , NIELSEN, Mette, Juul , LARSEN, Lisa , OERSNES-LEEMING, Diane, Julie , KARSDAL, Morten
IPC分类号： G01N33/577 , G01N33/68
CPC分类号： G01N33/6887 , G01N33/577 , G01N2333/78 , G01N2800/085 , G01N2800/52 , G01N2800/7052
摘要： Provided herein is a sandwich immunoassay for detecting cross-linked PIIINP that has at least two strands of PIIINP joined together by inter-strand cross-linking each having a C-terminal neo-epitope of PIIINP that is generated by N-protease cleavage of intact type III procollagen. A biological sample having the cross-linked PIIINP is contacted with a first surface-bound monoclonal antibody and then by a second monoclonal antibody, both specifically reactive with a neoepitope in the C-terminal sequence of PIIINP, and then binding of the second monoclonal antibody is determined. Also provided is a method for evaluating the efficacy of an antagonist drug targeting lysyl oxidases via the immunoassay and a kit containing a solid support binding the first monoclonal antibody and containing the second monoclonal antibody.
-
公开(公告)号：EP2715360B1
公开(公告)日：2016-08-17
申请号：EP12723653.7
申请日：2012-05-23
IPC分类号： G01N33/564
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/564 , G01N33/6842 , G01N2333/78 , G01N2800/102
-
公开(公告)号：EP2989124A1
公开(公告)日：2016-03-02
申请号：EP14722595.7
申请日：2014-04-23
IPC分类号： C07K16/18 , G01N33/577 , G01N33/68
CPC分类号： G01N33/6887 , C07K16/18 , C07K2317/34 , G01N2333/78
摘要： An antibody which binds to an epitope of collagen type VI alpha 1 comprised in the N-terminal globular domain internal amino acid sequence -ADWGQSRDAEEAISQ- (SEQ ID NO: 1), and a method of immunoassay for detecting in a biological sample an epitope comprised in the N-terminal globular domain internal amino acid sequence -ADWGQSRDAEEAISQ- (SEQ ID NO: 1) of collagen type VI alpha 1, by contacting said sample with said antibody, and determining the amount of binding of said antibody.
-
30.发明公开IN VITRO ASSESSMENT OF CARDIOVASCULAR EVENTS BY ASSAY FOR NEO-EPITOPES OF TITIN PROTEIN 有权体外评估根据测试心血管事件的新表位的肌联蛋白蛋白质
公开(公告)号：EP2731960A1
公开(公告)日：2014-05-21
申请号：EP12731501.8
申请日：2012-07-06
CPC分类号： G01N33/6887 , C07K14/4716 , C07K16/18 , C07K2317/34 , G01N33/566 , G01N33/6893 , G01N2333/4712 , G01N2800/32
摘要： A bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a titin protein by a proteinase comprises contacting a sample with an antibody specifically binding said neo-epitope and determining the level of binding. Partial sequences of titin that may be detected include: 3519' ↓GEYVCDCGTD '13528, 3532' NVTVEARLIK↓ '13542, 3543'↓VEKPLYGVEV '1553.
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.015 秒)
