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30 条记录 (耗时 0.026 秒)

    Method for the reduction of allyl alcohols
    23.
    发明公开
    Method for the reduction of allyl alcohols 失效
    Verfahren zur Reduktion von Allylalkoholen。

    公开(公告)号：EP0543526A1

    公开(公告)日：1993-05-26

    申请号：EP92310036.6

    申请日：1992-11-02

    申请人： SHIONOGI & CO., LTD.

    发明人： Ohtani, Mitsuaki ,  Matsuura, Takaharu ,  Hamada, Yoshinori ,  Yamada, Isamu ,  Sakata, Teruo ,  Takahashi, Kimio ,  Kishi, Morio

    IPC分类号： C07D307/93 ,  C07B31/00

    CPC分类号： C07D307/935

    摘要： A method for the reduction of an allyl alcohol-type compound specific to its allylic hydroxyl group, which is carried out without any side reactions, such as reduction of other parts of the compound and allylic rearrangement, which method comprises treating said compound with a trialkylsilane in the presence of A1X₃, wherein X is a halogen atom.

    摘要翻译： 一种降低其烯丙基羟基特异性的烯丙醇型化合物的方法，其没有任何副反应进行，例如化合物的其它部分的还原和烯丙基重排，该方法包括用三烷基硅烷处理所述化合物 在AlX 3存在下，其中X是卤素原子。

    Monoesters of arylacetic acid, their production and use
    29.
    发明公开
    Monoesters of arylacetic acid, their production and use 失效
    Arylessigsäuremonoester，deren Herstellung und Verwendung。

    公开(公告)号：EP0373931A2

    公开(公告)日：1990-06-20

    申请号：EP89313075.7

    申请日：1989-12-14

    申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

    发明人： Ohtani, Mitsuaki ,  Matsuura, Takaharu ,  Konoike, Toshiro ,  Araki, Yoshitaka

    IPC分类号： C07C69/753 ,  C07C67/08

    CPC分类号： C07C69/753 ,  Y02P20/55

    摘要： The invention provides optically active esters of arylacetic acid of the formula:
    wherein R¹ is hydrogen or optionally substituted C₁-C₂ alkyl or phenyl or when both taken together form C₂-C₆ alkylene, C₂ or C₄-C₆ alkenylene, or a bicyclic-ring; R² is hydrogen or methyl; X is a single bond or CH₂, C=O, N-R⁴, O, S, CHNHR⁴, CHCH₃, CH-Ar, or CHOR⁵ (provided that when X is single bond or CH₂, C=O, N-R⁴, O, or S, R¹ and R² are not simultaneously hydrogen or methyl); R³ is hydrogen, optionally substituted alkyl, or optionally substituted aralkyl; R⁴ is hydrogen or an amino protecting group; R⁵ is hydrogen or a hydroxy protecting group; and Ar is optionally substituted aryl. These esters may be prepared by the reaction of a σ symmetric acid anhydride with an (R)- or (S)-arylacetic acid derivative in high optical purity, and are useful as intermediates for various optically active natural products and medicines.

    摘要翻译： 本发明提供下式的芳基乙酸的光学活性酯：其中R 1为氢或任选取代的C 1 -C 2烷基或苯基，或两者一起形成C 2 -C 6亚烷基，C 2或C 4 -C 6亚烯基， 或双环; R 2是氢或甲基; X是单键或CH 2，C = O，NR 4，O，S，CHNHR 4，CHCH 3，CH-Ar或CHOR 5（条件是当X是单键或CH 2时，C = O，NR 4，O或S，R 1和R 2不同时为氢或甲基）; R 3是氢，任选取代的烷基或任选取代的芳烷基; R 4是氢或氨基保护基; R 5是氢或羟基保护基; 并且Ar是任选取代的芳基。 这些酯可以通过σ对称酸酐与高光学纯度的（R） - 或（S） - 芳基乙酸衍生物的反应制备，并且可用作各种光学活性天然产物和药物的中间体。