公开(公告)号：EP2938622B8

公开(公告)日：2016-12-21

申请号：EP13721103.3

申请日：2013-03-25

申请人： Instytut Chemii Organicznej PAN

发明人： GRELA, Karol ,  GAWIN, Rafal ,  PIECZYKOLAN, Michal

IPC分类号： C07F15/00 ,  B01J31/22

CPC分类号： B01J31/2404 ,  B01J31/2265 ,  B01J2231/52 ,  B01J2231/543 ,  B01J2531/821 ,  C07C41/30 ,  C07D307/935 ,  C07F15/0046

公开(公告)号：EP2938622A1

公开(公告)日：2015-11-04

申请号：EP13721103.3

申请日：2013-03-25

申请人： Instytut Chemii Organicznej Pan

发明人： GRELA, Karol ,  GAWIN, Rafal ,  PIECZYKOLAN, Michal

IPC分类号： C07F15/00 ,  B01J31/22

CPC分类号： B01J31/2404 ,  B01J31/2265 ,  B01J2231/52 ,  B01J2231/543 ,  B01J2531/821 ,  C07C41/30 ,  C07D307/935 ,  C07F15/0046

摘要： The subject of the present invention are novel, chiral non-racemic ruthenium complexes defined by the general Formula 1, The present invention also relates to methods of manufacturing of a novel, chiral non-racemic ruthenium complexes defined by the general Formula 1 as well as their use in asymmetric olefin metathesis reactions.

公开(公告)号：EP2495235B1

公开(公告)日：2015-08-05

申请号：EP11157027.1

申请日：2011-03-04

申请人： Newchem S.p.A.

发明人： Mariani, Edoardo ,  Orru', Gianmauro ,  Montorsi, Mauro ,  Andriolo, Erika ,  Bandini, Marco ,  Contento, Michele ,  Tolomelli, Alessandra

IPC分类号： C07C405/00 ,  C07D307/935

CPC分类号： C07C405/0016 ,  C07C405/0041 ,  C07D307/935

公开(公告)号：EP2636665A1

公开(公告)日：2013-09-11

申请号：EP11837836.3

申请日：2011-10-11

申请人： National University Corporation Nagoya University

发明人： ISHIHARA, Kazuaki ,  UYANIK, Muhammet

IPC分类号： C07C67/42 ,  C07C69/24 ,  C07D307/33 ,  C07D307/77 ,  C07D307/79 ,  C07D309/30 ,  C07D313/04 ,  C07B61/00

CPC分类号： C07D313/04 ,  C07B33/00 ,  C07C37/56 ,  C07C67/42 ,  C07D307/33 ,  C07D307/77 ,  C07D307/79 ,  C07D307/83 ,  C07D307/88 ,  C07D307/935 ,  C07D309/30 ,  C07D323/04 ,  C07C69/24 ,  C07C39/28

摘要： The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr 4 ) n , which is a metal borate, is used (M represents an alkali metal or an alkaline earth metal; Ar represents an aryl; and n is the same number as the valence of M). For example, when cyclohexanone was used as the reactive substrate, and Sr[B(3,5-CF 3 C 6 H 3 ) 4 ] 2 was used as the catalyst, ε-caprolactone was obtained at an isolated yield of 82%.

摘要翻译： 本发明涉及通过使用过氧化氢的Baeyer-Villiger氧化反应从作为反应性底物的酮或醛制造酯的方法，在该方法中，作为催化剂M（BAr 4）n （M表示碱金属或碱土金属; Ar表示芳基; n表示与M的化合价相同的数）。 例如，使用环己酮作为反应性底物，使用Sr [B（3,5-CF 3 C 6 H 3）4] 2作为催化剂时，以82％的分离收率得到μ-己内酯。

公开(公告)号：EP2429982A4

公开(公告)日：2012-09-12

申请号：EP10733172

申请日：2010-01-22

申请人： APOTEX PHARMACHEM INC

发明人： KOTHAKONDA KIRAN KUMAR ,  WANG FAN ,  GUNTOORI BHASKAR REDDY ,  NGUYEN MINH T N ,  CECCARELLI ALFREDO PAUL ,  ZHAO YAJUN ,  KOTIPALLI UMA ,  DUNCAN SAMMY CHRIS ,  MILNEE KAARINA K ,  KELLS KEVIN W ,  MONTEMAYOR LAURA KAYE

IPC分类号： C07C69/734 ,  C07C59/66 ,  C07C69/738 ,  C07C405/00 ,  C07D307/935 ,  C07D311/94 ,  C07F7/18

CPC分类号： C07F7/1892 ,  C07C69/734 ,  C07C69/738 ,  C07C405/00 ,  C07C2601/08 ,  C07D307/935

公开(公告)号：EP2311820A1

公开(公告)日：2011-04-20

申请号：EP10186205.0

申请日：2002-05-24

申请人： Resolution Chemicals Limited

发明人： Greenwood, Alan ,  McHattie, Derek ,  Thompson, David ,  Clissold, Derek

IPC分类号： C07D307/935 ,  C07C405/00 ,  C07F7/18

CPC分类号： C08F295/00 ,  C07C405/00 ,  C07D307/935 ,  C07F7/1856 ,  C07F7/1892

摘要： Disclosed are processes for the synthesis and purification of prostaglandins and analogues thereof, especially analogues of PGF 2α .

摘要翻译： 公开了前列腺素及其类似物的合成和纯化的方法，特别是PGF2±的类似物。

公开(公告)号：EP2143712A1

公开(公告)日：2010-01-13

申请号：EP08160099.1

申请日：2008-07-10

申请人： SANDOZ AG

发明人： Albert, Martin ,  Berger, Andreas ,  De Souza, Dominic ,  Knepper, Kerstin ,  Sturm, Hubert

IPC分类号： C07C405/00 ,  C07D307/93

CPC分类号： C07C405/00 ,  C07D307/935

摘要： The present invention relates to an improved process for the production of prostaglandins and prostaglandin analogs. In particular, this invention relates to the production of prostaglandins of the PGF 2α -series, including latanoprost, travoprost, and bimatoprost, which are active pharmaceutical ingredients used for the reduction of elevated intraocular pressure in patients with glaucoma and ocular hypertension.

摘要翻译： 本发明涉及一种生产前列腺素和前列腺素类似物的改进方法。 特别地，本发明涉及PGF 2± - 系列的前列腺素的生产，包括拉坦前列素，曲伏前列素和比马前列素，它们是用于降低青光眼和高眼压患者眼内压升高的活性药物成分。

公开(公告)号：EP2047758A1

公开(公告)日：2009-04-15

申请号：EP07118147.3

申请日：2007-10-09

申请人： V. Mane Fils

发明人： Mane, Jean ,  Plessis, Caroline

IPC分类号： A23L1/03 ,  C11B9/00 ,  C07C33/12 ,  C07D307/93

CPC分类号： C07C33/12 ,  A23L27/2052 ,  A23L29/035 ,  C07C2601/10 ,  C07D307/935 ,  C07D307/937 ,  C11B9/003 ,  C11B9/0076

摘要： A compound of general formula (I)

wherein
R 1 , R 2 , R 3 , and R 4 are, independently, a hydrogen atom or an optionally substituted linear or branched C 1 -C 6 alkyl or C 2 -C 6 alkenyl group,
provided that when each of R 1 , R 2 , and R 3 are a hydrogen atom, R 4 is not a phenyl substituted linear or branched C 1 -C 6 alkyl or C 2 -C 6 alkenyl group; and
with the proviso that the compound of formula (I) is neither 6,6,6a-trimethyl-hexahydro-cyclopenta[b]furan, 6,6,6a-trimethyl-2-ethyl-hexahydro-cyclopenta[b]furan, nor 6,6,6a-trimethyl-2-propyl-hexahydro-cyclopenta[b]furan and use thereof in a fragrant and/or flavouring composition.

摘要翻译： 其中R 1，R 2，R 3和R 4独立地为氢原子或任选取代的直链或支链C 1 -C 6烷基或C 2 -C 6烯基的通式（I）的化合物， 条件是当R 1，R 2和R 3各自为氢原子时，R 4不是苯基取代的直链或支链C 1 -C 6烷基或C 2 -C 6烯基; 并且条件是式（I）化合物既不是6,6,6a-三甲基 - 六氢 - 环戊二烯并[b]呋喃，6,6,6a-三甲基-2-乙基 - 六氢 - 环戊二烯并[b]呋喃， 也不是6,6,6a-三甲基-2-丙基 - 六氢 - 环戊二烯并[b]呋喃及其在芳香和/或调味组合物中的用途。

公开(公告)号：EP1694641B1

公开(公告)日：2009-04-15

申请号：EP04801246.2

申请日：2004-12-01

申请人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY

发明人： CLISSOLD, Derek Wyndham ,  CRAIG, Stuart Wilbert ,  GADIKOTA, Rajendrakumar, Reddy ,  HE, Min ,  JURAYJ, Jurjus Fayez ,  KAZERANI, Shahrokh ,  RANNALA, Erwin ,  SHARMA, Pradeep, Kumar

IPC分类号： C07C405/00 ,  C07D309/12

CPC分类号： C07D307/935 ,  C07C405/00 ,  C07C405/0016 ,  C07D309/12 ,  C07D407/12 ,  Y02P20/55

摘要： A process for the preparation of prostaglandin compounds having the formula (I); wherein A is selected from the group consisting Of C1-C6 alkyl; C7-C16 aralkyl wherein the aryl group is optionally substituted with one to three substituents selected from the group consisting Of C1 -C6 alkyl, halo and CF3; and (CH2)nOR' wherein n is from 1 to 3 and R' represents a C6-Cl0 aryl group which is optionally substituted with one to three substituents selected from the group consisting Of C1-C6 alkyl, halo and CF3; B is selected from OR' and NHR' wherein R' is C1-C6 alkyl; and formula (a) represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

公开(公告)号：EP1981867A2

公开(公告)日：2008-10-22

申请号：EP07714040.8

申请日：2007-02-06

申请人： R-Tech Ueno, Ltd.

发明人： HIRATA, Ryu ,  MATSUKAWA, Tatsuya ,  MASUZAKI, Kazuhiro , 

IPC分类号： C07D307/93 ,  C07D311/94 ,  C07C405/00

CPC分类号： C07D307/93 ,  C07C405/0025 ,  C07D307/935 ,  C07D309/12 ,  C07D311/94

摘要： Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.