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公开(公告)号：EP1954678A1
公开(公告)日：2008-08-13
申请号：EP06830200.9
申请日：2006-11-30
发明人： JASSERAND, Daniel , SCHOEN, Uwe , ANTEL, Jochen , FIRNGES, Michael , REICHE, Dania , SANN, Holger , BRÜCKNER, Reinhard
IPC分类号： C07D213/38 , C07D295/12 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/58 , C07D407/06 , C07D409/06 , A61K31/4965 , A61K31/497 , A61P1/00
CPC分类号： C07D295/13 , C07D213/38 , C07D295/125 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/58 , C07D407/06 , C07D409/06
摘要： The present invention relates to novel 3-cyano-naphthalene-1-carboxylic acid perhydroxyalkylmethyl-piperazine compounds of formula I which are antagonistic to tachykinin receptors. The present invention is further directed to pharmaceutical compositions comprising such compounds, to processes for the preparation of such compounds and to intermediate products of these processes.
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22.发明授权NEUE 1-AMIDOMETHYLCARBONYL-PIPERIDINDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL 有权新的1 AMIDOMETHYLCARBONYL哌啶，方法生产它们及药物含
公开(公告)号：EP1392679B1
公开(公告)日：2005-11-02
申请号：EP02754561.5
申请日：2002-05-04
发明人： JASSERAND, Daniel , ANTEL, Jochen , PREUSCHOFF, Ulf , BRÜCKNER, Reinhard , SANN, Holger , WURL, Michael , EICKELMANN, Peter
IPC分类号： C07D401/06 , C07D405/14 , A61K31/454 , A61P1/04 , A61P1/06
CPC分类号： C07D401/06 , C07D211/32 , C07D405/14
摘要： The invention relates to novel, motilin-agonistically active compounds of general formula I, wherein R?1, R2, R3¿, Ar and n have the meaning as cited in the description. The invention also relates to medicaments containing said compounds and to a method for producing the novel compounds and intermediate products according to said method.
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23.发明授权VERFAHREN ZUM AUFFINDEN VON VERBINDUNGEN, WELCHE ZUR BEHANDLUNG UND/ODER PROPHYLAXE VON OBESITAS GEEIGNET SIND 有权方法用于搜索CONNECTIONS其中治疗和/或肥胖的预防是合适的
公开(公告)号：EP1307262B1
公开(公告)日：2004-10-06
申请号：EP01955345.2
申请日：2001-07-12
发明人： HEBEBRAND, Johannes , ANTEL, Jochen , PREUSCHOFF, Ulf , DAVID, Samuel , SANN, Holger , WESKE, Michael
CPC分类号： C12Q1/527
摘要： The invention relates to a method for locating compounds which are suitable for the treatment and/or prophylaxis of obesity, whereby the ability of the examined compounds to inhibit de novo lipogenase in mammals and/or humans is determined. Also disclosed is the use of compounds which are capable of inhibiting de novo lipogenase in mammals in the production of medicaments for the treatment and/or phophylaxis of obesity.
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24.发明授权VERFAHREN ZUR STEREOCHEMISCH KONTROLLIERTEN HERSTELLUNG ISOMERENREINER HOCHSUBSTITUIERTER AZACYCLISCHER VERBINDUNGEN 有权对于立体声化学控制的制造方法异构高取代的氮杂环CONNECTIONS
公开(公告)号：EP1076646B1
公开(公告)日：2004-08-04
申请号：EP99934470.8
申请日：1999-05-10
IPC分类号： C07D207/12 , C07D209/52 , C07D291/04 , C07C381/10 , C07F7/10
CPC分类号： C07D291/04 , C07C381/10 , C07D207/12 , C07D209/52 , Y02P20/55
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25.发明公开VERFAHREN ZUR STEREOCHEMISCH KONTROLLIERTEN HERSTELLUNG ISOMERENREINER HOCHSUBSTITUIERTER AZACYCLISCHER VERBINDUNGEN 有权对于立体声化学控制的制造方法异构高取代的氮杂环CONNECTIONS
公开(公告)号：EP1076646A1
公开(公告)日：2001-02-21
申请号：EP99934470.8
申请日：1999-05-10
IPC分类号： C07D207/12 , C07D209/52 , C07D291/04 , C07C381/10 , C07F7/10
CPC分类号： C07D291/04 , C07C381/10 , C07D207/12 , C07D209/52 , Y02P20/55
摘要： The invention relates to a method for stereochemically controlled production of azacyclic compounds of general formula (I), whereby the substituents have the meaning cited in the description. The invention also relates to intermediate products of this method and to novel azacyclenes.
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