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1.发明公开NEUE 1-AMIDOMETHYLCARBONYL-PIPERIDINDERIVATE, VERFAHREN UND ZWISCHENPRODUKTE ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL 有权新的1 AMIDOMETHYLCARBONYL哌啶，方法生产它们及药物含
公开(公告)号：EP1392679A1
公开(公告)日：2004-03-03
申请号：EP02754561.5
申请日：2002-05-04
发明人： JASSERAND, Daniel , ANTEL, Jochen , PREUSCHOFF, Ulf , BRÜCKNER, Reinhard , SANN, Holger , WURL, Michael , EICKELMANN, Peter
IPC分类号： C07D401/06 , C07D405/14 , A61K31/454 , A61P1/04 , A61P1/06
CPC分类号： C07D401/06 , C07D211/32 , C07D405/14
摘要： The invention relates to novel, motilin-agonistically active compounds of general formula I, wherein R?1, R2, R3¿, Ar and n have the meaning as cited in the description. The invention also relates to medicaments containing said compounds and to a method for producing the novel compounds and intermediate products according to said method.
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2.发明公开NOVEL DUAL NK2/NK3-ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESSES FOR THEIR PREPARATIONS 审中-公开新的双NK2 / NK3拮抗剂，药物组合物含有它们及其制造方法
公开(公告)号：EP1979319A1
公开(公告)日：2008-10-15
申请号：EP07704286.9
申请日：2007-02-01
发明人： JASSERAND, Daniel , MENTZEL, Matthias , JAUNZEMS, Janis , BENSON, Werner , PREUSCHOFF, Ulf , FIRNGES, Michael , SANN, Holger , BRÜCKNER, Reinhard , ADOLFS, Martinus , ATTALI, Amos , SMID, Peter , SCHÖN, Uwe , REICHE, Dania , McCREARY, Andrew, Christopher
IPC分类号： C07D211/66 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D401/04 , C07D211/62 , C07D295/14 , C07D211/58 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/445
CPC分类号： C07D211/66 , C07D211/58 , C07D211/62 , C07D295/155 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to novel dual NK2/NK3-antagonists of formula (I) wherein the meaning of X and R1 to R5 is defined in the claims and in the description and also to pharmaceutical compositions comprising these compounds. Furthermore, the invention relates to processes for the preparation of the novel dual NK2/NK3-antagonists and to their uses.
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公开(公告)号：EP1954678A1
公开(公告)日：2008-08-13
申请号：EP06830200.9
申请日：2006-11-30
发明人： JASSERAND, Daniel , SCHOEN, Uwe , ANTEL, Jochen , FIRNGES, Michael , REICHE, Dania , SANN, Holger , BRÜCKNER, Reinhard
IPC分类号： C07D213/38 , C07D295/12 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/58 , C07D407/06 , C07D409/06 , A61K31/4965 , A61K31/497 , A61P1/00
CPC分类号： C07D295/13 , C07D213/38 , C07D295/125 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/58 , C07D407/06 , C07D409/06
摘要： The present invention relates to novel 3-cyano-naphthalene-1-carboxylic acid perhydroxyalkylmethyl-piperazine compounds of formula I which are antagonistic to tachykinin receptors. The present invention is further directed to pharmaceutical compositions comprising such compounds, to processes for the preparation of such compounds and to intermediate products of these processes.
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4.发明授权NEUE 1-AMIDOMETHYLCARBONYL-PIPERIDINDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL 有权新的1 AMIDOMETHYLCARBONYL哌啶，方法生产它们及药物含
公开(公告)号：EP1392679B1
公开(公告)日：2005-11-02
申请号：EP02754561.5
申请日：2002-05-04
发明人： JASSERAND, Daniel , ANTEL, Jochen , PREUSCHOFF, Ulf , BRÜCKNER, Reinhard , SANN, Holger , WURL, Michael , EICKELMANN, Peter
IPC分类号： C07D401/06 , C07D405/14 , A61K31/454 , A61P1/04 , A61P1/06
CPC分类号： C07D401/06 , C07D211/32 , C07D405/14
摘要： The invention relates to novel, motilin-agonistically active compounds of general formula I, wherein R?1, R2, R3¿, Ar and n have the meaning as cited in the description. The invention also relates to medicaments containing said compounds and to a method for producing the novel compounds and intermediate products according to said method.
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