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    SOLID FORMS OF AN ALPHA, OMEGA DI-SUBSTITUTED DIHYDROXY CYCLOPENTYL COMPOUND AND METHODS FOR THE PREPARATION AND USE THEREOF
    7.
    发明公开
    SOLID FORMS OF AN ALPHA, OMEGA DI-SUBSTITUTED DIHYDROXY CYCLOPENTYL COMPOUND AND METHODS FOR THE PREPARATION AND USE THEREOF 审中-公开
    以对其及其用途产生α的固体形式，OMEGA二取代环戊基CONNECTION和方法

    公开(公告)号：EP3080096A1

    公开(公告)日：2016-10-19

    申请号：EP14824284.5

    申请日：2014-12-12

    申请人： ALLERGAN, INC.

    发明人： WU, Ke ,  AMBRUS, Gyorgy

    IPC分类号： C07D333/28 ,  A61K31/381 ,  A61P27/06

    CPC分类号： A61K31/559 ,  A61K9/0048 ,  C07D333/28

    摘要： Provided herein are multiple solid forms of a defined α,{acute over (ω)}-disubstituted dihydroxy cyclopentyl compound, and methods for the preparation and use thereof. In one aspect, there are provided crystalline forms of said cyclopentyl compound, and methods for the preparation and use thereof. In another aspect, there are provided substantially amorphous forms of said dihydroxy cyclopentyl compound, and methods for the preparation and use thereof. In yet another aspect, there are provided compositions containing compounds according to the present invention. In certain aspects, such compositions are suitable for delivery of active agents according to the present invention to a subject in need thereof. In another aspect of the invention, there are provided methods for the treatment of a variety of indications, including glaucoma, ocular hypertension, and the like. In still another aspect of the present invention, there are provided kits containing compounds according to the present invention and/or compositions containing same.

    摘要翻译： 本发明提供在限定的α的多个固体形式，{急性以上（ω）} - 二取代二羟基环戊基化合物和方法用于制备及其用途。 在一个方面，提供了说环戊基化合物的结晶形式，和方法用于制备及其用途。 在另一个方面，提供了说二羟基环戊基化合物的基本上无定形的形式，和方法用于制备及其用途。 在又一个方面中，提供了含有化合物gemäß到本发明的组合物。 在某些方面，寻求组合物适合用于递送gemäß到本发明对需要其的受试者的活性剂。 在本发明的另一个方面，提供了用于多种适应症，包括青光眼，高眼压症，等处理提供的方法。 在沉默本发明的另一个方面，提供了含有化合物gemäß到本发明的试剂盒和/或组合物含有相同。