公开(公告)号：EP2155674A1

公开(公告)日：2010-02-24

申请号：EP08763731.0

申请日：2008-04-15

申请人： Suven Life Sciences Limited

发明人： NIROGI, Ramakrishna ,  KAMBHAMPATI, Rama, Sastri ,  SHINDE, Anil, Karbhari ,  DAULATABAD, Anand, Vijaykumar ,  DWARAMPUDI, Adi, Reddy ,  KANDIKERE, Nagaraj, Vishwottam ,  VISHWAKARMA, Santosh ,  JASTI, Venkateswarlu

IPC分类号： C07D209/08 ,  C07D209/30 ,  C07D401/12 ,  A61P25/00 ,  A61K31/454 ,  A61K31/404

CPC分类号： C07D209/08 ,  C07D209/30 ,  C07D401/12

摘要： The present invention relates to novel aminoalkoxy arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.

公开(公告)号：EP2121602A1

公开(公告)日：2009-11-25

申请号：EP07827524.5

申请日：2007-07-26

申请人： Suven Life Sciences Limited

发明人： RAMAKRISHNA, Nirogi, Venkata, Satya ,  KAMBHAMPATI, Rama, Sastri ,  DESHPANDE, Amol, Dinkar ,  JASTI, Venkateswarlu

IPC分类号： C07D209/30 ,  A61K31/404 ,  A61P25/00

CPC分类号： C07D209/30

摘要： The present invention relates to novel 4-(Heterocyclyl)alkyl-N- (arylsulfonyl)indole compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.

公开(公告)号：EP2114878A1

公开(公告)日：2009-11-11

申请号：EP07827525.2

申请日：2007-07-26

申请人： Suven Life Sciences Limited

发明人： RAMAKRISHNA, Nirogi, Venkata, Satya ,  KAMBHAMPATI, Rama, Sastri ,  KONDA, Jagadishbabu ,  KOTHMIRKAR, Prabhakar ,  JASTI, Venkateswarlu

IPC分类号： C07D209/08 ,  A61K31/404 ,  A61P25/00

CPC分类号： C07D209/08 ,  C07D209/36

摘要： The present invention relates to novel 5-(Heterocyclyl)alkyl-N- (arylsulfonyl)indole compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.

公开(公告)号：EP1537113B1

公开(公告)日：2009-10-07

申请号：EP03760859.3

申请日：2003-06-19

申请人： Suven Life Sciences Limited

发明人： JASTI, Venkateswarlu ,  RAMAKRISHNA, Venkata, Satya, Nirogi ,  KAMBHAMPATI, Rama, Sastri ,  BATTULA, Srinivasa, Reddy ,  RAO, Venkata, Satya, Veerabhadra, Vadlamudi

IPC分类号： C07D487/04 ,  A61K31/40 ,  A61P5/00

CPC分类号： C07D487/04

摘要： The present invention relates to novel tetracyclic arylalkyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylalkyl of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy.

公开(公告)号：EP1517909B1

公开(公告)日：2006-10-25

申请号：EP03760858.5

申请日：2003-06-19

申请人： Suven Life Sciences Limited

发明人： JASTI, Venkateswarlu ,  RAMAKRISHNA, Venkata, Satya, Nirogi ,  KAMBHAMPATI, Rama, Sastri ,  BATTULA, Srinivasa, Reddy ,  RAO, Venkata, Satya, Veerabhadra, Vadlamudi

IPC分类号： C07D487/04 ,  A61K31/407 ,  A61P25/00 ,  C07D209/14 ,  A61K51/00

CPC分类号： C07D487/04 ,  A61K51/0446 ,  A61K51/0459 ,  A61K51/0463 ,  C07D471/04

摘要： The present invention relates to novel tetracyclic arylcarbonyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylcarbonyl indoles of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy