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1.发明授权4-(HETEROCYCLYL)ALKYL-N-(ARYLSULFONYL) INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS 有权4-（杂环基）烷基-N-（芳基磺酰基）吲哚类化合物及其作为5-HT 6配体的
公开(公告)号：EP2121602B1
公开(公告)日：2015-03-18
申请号：EP07827524.5
申请日：2007-07-26
发明人： RAMAKRISHNA, Nirogi, Venkata, Satya , KAMBHAMPATI, Rama, Sastri , DESHPANDE, Amol, Dinkar , JASTI, Venkateswarlu
IPC分类号： C07D209/30 , A61K31/404 , A61P25/00
CPC分类号： C07D209/30
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2.发明授权AMINOALKOXY ARYL SULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS 有权氨基烷氧基 - 芳基磺酰胺化合物及其作为5-HT 6配体的用途
公开(公告)号：EP2155674B1
公开(公告)日：2011-06-22
申请号：EP08763731.0
申请日：2008-04-15
发明人： NIROGI, Ramakrishna , KAMBHAMPATI, Rama, Sastri , SHINDE, Anil, Karbhari , DAULATABAD, Anand, Vijaykumar , DWARAMPUDI, Adi, Reddy , KANDIKERE, Nagaraj, Vishwottam , VISHWAKARMA, Santosh , JASTI, Venkateswarlu
IPC分类号： C07D209/08 , C07D209/30 , C07D401/12 , A61P25/00 , A61K31/454 , A61K31/404
CPC分类号： C07D209/08 , C07D209/30 , C07D401/12
摘要： The present invention relates to novel aminoalkoxy arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.
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公开(公告)号：EP1948166A1
公开(公告)日：2008-07-30
申请号：EP06766266.8
申请日：2006-06-09
发明人： RAMAKRISHNA, Venkata, Satya, Nirogi , KAMBHAMPATI, Rama, Sastri , SHIRSATH, Vikas, Shreekrishna , KONDA, Jagadish, Babu , VISHWAKARMA, Santosh , JASTI, Venkateswarlu
IPC分类号： A61K31/403 , C07D209/88 , A61P25/00
CPC分类号： C07D209/88 , C07D209/94
摘要： The present invention provides carbazole derivatives of formula (I), useful in treatment of a CNS disorders related to or affected by the 5-HT6 receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HT6 receptor along with good selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicines containing the said carbazole derivatives.
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公开(公告)号：EP1919896A1
公开(公告)日：2008-05-14
申请号：EP05813800.9
申请日：2005-10-26
发明人： RAMAKRISHNA, Venkata, Satya, Nirogi , SHIRSATH, Vikas, Shreekrishna , KAMBHAMPATI, Rama, Sastri , VISHWAKARMA, Santosh , KANDIKERE, Nagaraj, Vishwottam , KOTA, Srinivasulu , JASTI, Venkateswarlu
IPC分类号： C07D401/12 , A61K31/4468 , A61K31/4523
CPC分类号： C07D401/12
摘要： The present invention provides aminoaryl sulphonamide derivatives of formula (I), useful in the treatment of a CNS disorder related to or affected by the 5-HTg receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HTg receptor along with good selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicine containing the said aminoaryl sulphonamide derivatives.
摘要翻译： 本发明提供式（I）的氨基芳基磺酰胺衍生物，其用于治疗与5-HTg受体相关或受其影响的CNS病症。 这些化合物的药理学特征包括与5-HTg受体的高亲和力结合以及对所述受体的良好选择性。 本发明还包括含有所述氨基芳基磺酰胺衍生物的立体异构体，盐，制备方法和药物。
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5.发明公开
公开(公告)号：EP1517909A2
公开(公告)日：2005-03-30
申请号：EP03760858.5
申请日：2003-06-19
发明人： JASTI, Venkateswarlu , RAMAKRISHNA, Venkata, Satya, Nirogi , KAMBHAMPATI, Rama, Sastri , BATTULA, Srinivasa, Reddy , RAO, Venkata, Satya, Veerabhadra, Vadlamudi
IPC分类号： C07D487/04 , A61K31/407 , A61P25/00 , C07D209/14 , A61K51/00
CPC分类号： C07D487/04 , A61K51/0446 , A61K51/0459 , A61K51/0463 , C07D471/04
摘要： The present invention relates to novel tetracyclic arylcarbonyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylcarbonyl indoles of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy
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公开(公告)号：EP2346847B1
公开(公告)日：2013-05-15
申请号：EP09787575.1
申请日：2009-03-03
发明人： NIROGI, Ramakrishna , SHINDE, Anil, Karbhari , KAMBHAMPATI, Rama, Sastri , JAYARAJAN, Pradeep , BHYRAPUNENI, Gopinadh , JASTI, Venkateswarlu
IPC分类号： C07D333/62 , C07D295/30
CPC分类号： C07D295/30 , C07D333/62
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公开(公告)号：EP1948166B1
公开(公告)日：2010-10-20
申请号：EP06766266.8
申请日：2006-06-09
发明人： RAMAKRISHNA, Venkata, Satya, Nirogi , KAMBHAMPATI, Rama, Sastri , SHIRSATH, Vikas, Shreekrishna , KONDA, Jagadish, Babu , VISHWAKARMA, Santosh , JASTI, Venkateswarlu
IPC分类号： A61K31/403 , C07D209/88 , A61P25/00
CPC分类号： C07D209/88 , C07D209/94
摘要： The present invention provides carbazole derivatives of formula (I), useful in treatment of a CNS disorders related to or affected by the 5-HT6 receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HT6 receptor along with good selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicines containing the said carbazole derivatives.
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8.发明公开AMINO ARYLSULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS FIELD OF INVENTION 有权AMINOARYLSULFONAMIDVERBINDUNGEN及其作为5-HT6配体
公开(公告)号：EP2200980A1
公开(公告)日：2010-06-30
申请号：EP08776656.4
申请日：2008-05-02
发明人： RAMAKRISHNA, Nirogi, Venkata, Satya , KAMBHAMPATI, Rama, Sastri , SHINDE, Anil, Karbhari , KANDIKERE, Nagaraj, Vishwottam , JASTI, Venkateswarlu
IPC分类号： C07D209/08 , A61K31/404 , A61P25/14 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D209/08
摘要： The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The compounds of the invention are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, obesity, anxiety, depression, diseases associated with pain, respiratory diseases, gastrointestinal, cardiovascular diseases and cancer.
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9.发明授权TETRACYCLIC ARYLSULFONYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY 有权具有亲和力TETRACYKLISCHE arylsulfonylindoles羟色胺受体
公开(公告)号：EP1523486B1
公开(公告)日：2007-11-07
申请号：EP03760857.7
申请日：2003-06-19
发明人： JASTI, Venkateswarlu , RAMAKRISHNA, Venkata, Satya, Nirogi , KAMBHAMPATI, Rama, Sastri , BATTULA, Srinivasa, Reddy , VEERARAEDDY, Arava , RAO, Venkata, Satya, Veerabhadra, Vadlamudi
IPC分类号： C07D513/04 , A61K31/429 , A61P25/00
CPC分类号： C07D513/04
摘要： The present invention relates to novel tetracyclic arylsulfonyl indoles according to General Formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylsulfonyl indoles of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy.
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公开(公告)号：EP2521714A1
公开(公告)日：2012-11-14
申请号：EP10725883.2
申请日：2010-03-24
发明人： NIROGI, Ramakrishna , SHINDE, Anil, Karbhari , KAMBHAMPATI, Rama, Sastri , BADANGE, Rajesh, Kumar , REBALLI, Veena , CHINDHE, Anil, Kashinath , NAMALA, Rambabu , MULLA, Mohamad, Sadik, Abdulhamid , AHMAD, Ishtiyaque , ABRAHAM, Renny , JASTI, Venkateswarlu
IPC分类号： C07D211/58 , C07D401/12 , C07D401/14 , A61K31/4468 , A61K31/4709 , A61K31/4725 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00
CPC分类号： C07D211/58 , A61K31/4468 , A61K31/4709 , A61K31/4725 , C07D401/12 , C07D401/14
摘要： The present invention relates to novel sulfone compounds as 5-HT
6 receptor ligands of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. These compounds are useful in the treatment/prevention of various disorders that are related to 5-HT
6 receptor functions.
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