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    HETERODIMERIC PROTEINS
    23.
    发明公开
    HETERODIMERIC PROTEINS 审中-公开
    高分子蛋白

    公开(公告)号：EP2951203A2

    公开(公告)日：2015-12-09

    申请号：EP14733393.4

    申请日：2014-03-17

    申请人： Xencor, Inc.

    发明人： MOORE, Gregory ,  DESJARLAIS, John ,  RASHID, Rumana ,  BERNETT, Matthew, J.

    IPC分类号： C07K16/06 ,  C07K16/28 ,  C07K16/46

    CPC分类号： C07K16/065 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/468 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/72

    摘要： In one aspect, the present invention provides heterodimeric antibodies comprising a first monomer comprising a first heavy chain constant domain comprising a first variant Fc domain and a first antigen binding domain and a second monomer comprising a second heavy chain constant domain comprising a second variant Fc domain and a second antigen binding domain. In an additional aspect the heterodimeric antibody comprises a first monomer comprising a heavy chain comprising a first Fc domain and a single chain Fv region (scFv) that binds a first antigen, wherein the scFv comprises a charged scFv linker. The heterodimeric antibody further comprises a second monomer comprising a first heavy chain comprising a second Fc domain and a first variable heavy chain and a first light chain.

    摘要翻译： 一方面，本发明提供异二聚体抗体，其包含第一单体，其包含第一重链恒定结构域，其包含第一变体Fc结构域和第一抗原结合结构域，第二单体包含第二重链恒定结构域，其包含第二变体Fc结构域 和第二抗原结合结构域。 在另一方面，异二聚体抗体包含第一单体，其包含重链，其包含结合第一抗原的第一Fc结构域和单链Fv区（scFv），其中所述scFv包含带电的scFv接头。 异二聚体抗体还包含第二单体，其包含第一重链，其包含第二Fc结构域和第一可变重链和第一轻链。

    HETERODIMERIC PROTEINS
    30.
    发明公开
    HETERODIMERIC PROTEINS 审中-公开

    公开(公告)号：EP3587448A1

    公开(公告)日：2020-01-01

    申请号：EP19175124.7

    申请日：2014-03-17

    申请人： Xencor, Inc.

    发明人： MOORE, Gregory ,  DESJARLAIS, John ,  RASHID, Rumana ,  BERNETT, Matthew J.

    IPC分类号： C07K16/06 ,  C07K16/28 ,  C07K16/46

    摘要： In one aspect, the present invention provides heterodimeric antibodies comprising a first monomer comprising a first heavy chain constant domain comprising a first variant Fc domain and a first antigen binding domain and a second monomer comprising a second heavy chain constant domain comprising a second variant Fc domain and a second antigen binding domain. In an additional aspect the heterodimeric antibody comprises a first monomer comprising a heavy chain comprising a first Fc domain and a single chain Fv region (scFv) that binds a first antigen, wherein the scFv comprises a charged scFv linker. The heterodimeric antibody further comprises a second monomer comprising a first heavy chain comprising a second Fc domain and a first variable heavy chain and a first light chain.