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1407 条记录 (耗时 0.02 秒)

    Novel compounds
    28.
    发明公开
    Novel compounds 失效
    新化合物

    公开(公告)号：EP0353955A3

    公开(公告)日：1991-08-14

    申请号：EP89307673.7

    申请日：1989-07-27

    申请人： BEECHAM GROUP PLC

    发明人： Bailey, Stuart Beecham Pharmaceuticals ,  Harnden, Michael Raymond Beecham Pharmaceuticals

    IPC分类号： C07F9/6561 ,  C07F9/6506 ,  C07F9/6512 ,  C07F9/38 ,  C07F9/40 ,  A61K31/52

    CPC分类号： C07F9/65616 ,  C07F9/4006 ,  C07F9/65067 ,  C07F9/65127

    摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof:
    wherein
    R₁ is hydroxy, amino, chloro or OR₇
    wherein
    R₇ is C₁₋₆ alkyl, phenyl or phenyl C₁₋₂ alkyl either of which phenyl moieties may be substituted by one or two substituents selected from halo, C₁₋₄ alkyl or C₁₋₄ alkoxy;
    R₂ is amino or, when R₁ is hydroxy or amino, R₂ may also be hydrogen;
    X is -CH₂CH₂- or a moiety of structure (a), (b) or (c):
    wherein
    n is 1 or 2; and
    R₃ is hydrogen or acyl;
    R₄ is a group of formula:
    wherein
    R₅ and R₆ are independently selected from hydrogen,
    C₁₋₆ alkyl and optionally substituted phenyl; having anitiviral activity, processes for their preparation and their use as pharmaceuticals.

    摘要翻译： 式（Ⅰ）化合物及其药学上可接受的盐：其中R 1是羟基，氨基，氯或OR 7，其中R 6是C 1-6烷基，苯基或苯基C 1-2烷基，其苯基部分可以被一个或两个取代基 选自卤素，C 1-4烷基或C 1-4烷氧基; R 2是氨基，或者当R 1是羟基或氨基时，R 2也可以是氢; X是-CH 2 CH 2 - 或结构（a），（b）或（c）的部分：其中n是1或2; 和R 3是氢或酰基; R 4是下式基团：其中R 5和R 6独立地选自氢，C 1-6烷基和任意取代的苯基; 具有抗病毒活性，其制备方法及其作为药物的用途。