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1.发明公开POLYCATIONIC METHYL PHOSPHOLIPIDS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS 审中-公开聚阳离子METHYLPHOSPHOLIPIDE真核细胞中NUCLEIC改善RELEASE
公开(公告)号：EP2912045A2
公开(公告)日：2015-09-02
申请号：EP13852277.6
申请日：2013-10-28
发明人： GEBEYEHU, Gulilat , JESSEE, Joel
IPC分类号： C07F9/10
CPC分类号： C07F9/10 , C07F9/106 , C07F9/65067 , C12N15/113 , C12N15/88 , C12N2310/14 , C12P21/00
摘要： New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
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2.发明授权COMPOSITIONS COMPRENANT DES LIPOPHOSPHORAMIDES ET LEURS UTILISATIONS EN THERAPIE GENIQUE 有权LIPOPHOSPHORAMIDE含筹备工作及其用途的基因治疗
公开(公告)号：EP2193204B1
公开(公告)日：2011-08-31
申请号：EP08839001.8
申请日：2008-09-25
发明人： CLEMENT, Jean-Claude , PICHON, Harivony , MIDOUX, Patrick , YAOUANC, Jean-Jacques , MEVEL, Mathieu
IPC分类号： C12N15/88 , A61K48/00 , A61K47/24 , A61K31/664 , A61K45/06 , C07F9/22 , A61K31/7084
CPC分类号： A61K31/664 , A01K2207/30 , A01K2227/105 , A01K2267/03 , A61K9/1272 , A61K31/7084 , A61K48/00 , C07F9/2458 , C07F9/65061 , C07F9/65067 , C12N15/88
摘要： The invention relates to novel co-lipids that can be used in combination with lipophilic compounds used as nucleic acid vectors, for making a nucleic-acid vector composition. The invention also relates to nucleic-acid vector compositions containing a combination of (i) a nucleic-acid cationic lipohilic vector and (ii) a co-lipid. In some embodiments, the nucleic-acid vector compositions are in the form of unilamellar or multilamellar vesicles. The invention also relates to a method for the in vitro or in vivo insertion of a nucleic acid of interest into host cells, that comprises the step of contacting said host cells with a nucleic-acid vector composition as described above.
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3.发明公开N-(PHOSPHONOALKYL)-AMINO ACIDS, DERIVATIVES THEREOF AND COMPOSITIONS AND METHODS OF USE 审中-公开N-（膦酰基烷基）氨基酸，其衍生物，及其组合物和方法的使用
公开(公告)号：EP1979366A4
公开(公告)日：2011-05-25
申请号：EP07717264
申请日：2007-01-09
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： YU RUEY J , VAN SCOTT EUGENE J
IPC分类号： C07F9/38
CPC分类号： C07F9/582 , A61K38/05 , C07F9/3808 , C07F9/5721 , C07F9/5728 , C07F9/65067 , C07F9/653
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公开(公告)号：EP1765850B1
公开(公告)日：2010-12-01
申请号：EP05771589.8
申请日：2005-06-03
发明人： CHOI-SLEDESKI, Yong Mi , LEVELL, Julian , POLI, Gregory, Bernard , CZEKAJ, Mark , COLLIS, Alan, John , VAZ, Roy
IPC分类号： C07K5/06 , C07F9/30 , A61K31/4045 , A61K38/05 , A61P25/00
CPC分类号： C07K5/0827 , A61K38/00 , C07F9/301 , C07F9/303 , C07F9/5727 , C07F9/5728 , C07F9/65037 , C07F9/65067 , C07K5/06191
摘要： The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula (I) wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.
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5.发明公开ALPHA-AMINO ACID PHOSPHONIC ACID COMPOUNDS, METHOD OF PREPARATION AND USE THEREOF 有权α-氨基酸膦酸化合物，其制备方法和用途
公开(公告)号：EP2054423A1
公开(公告)日：2009-05-06
申请号：EP07725579.2
申请日：2007-05-25
IPC分类号： C07F9/38 , C07F9/6506 , C02F5/14
CPC分类号： C02F5/14 , C02F5/12 , C02F2103/10 , C07F9/3873 , C07F9/65067
摘要： Novel aminoacid alkylphosphonic acid compounds are disclosed. These compounds can be used in multiple applications, in particular in a scale inhibitor functionality in aqueous systems, including in marine oil recovery.
摘要翻译： 公开了新的氨基酸烷基膦酸化合物。 这些化合物可用于多种应用，特别是用于含水系统中的防垢剂功能性，包括海洋石油采收。
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公开(公告)号：EP1478652B1
公开(公告)日：2007-04-25
申请号：EP03742541.0
申请日：2003-02-19
申请人： novosom AG
IPC分类号： C07F9/6506 , C07K5/062 , C07K5/078 , C07K5/09 , C07C229/16 , C07D233/64 , A61K9/127 , C12N15/88
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/495 , A61K31/5375 , A61K47/183 , A61K47/22 , A61K47/24 , C07C229/16 , C07C229/24 , C07D233/64 , C07D295/00 , C07F9/65067 , C07K5/06191 , C07K5/0827 , C12N15/88 , Y10T428/2991
摘要： The invention relates to amphoteric lipids. According to the invention, at least one amphoteric group having an isoelectric point between 4 and 9 is substituted on a membranous or membrane-forming amphiphile. The invention also relates to liposomes containing said compounds.
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公开(公告)号：EP1765850A1
公开(公告)日：2007-03-28
申请号：EP05771589.8
申请日：2005-06-03
发明人： CHOI-SLEDESKI, Yong Mi , LEVELL, Julian , POLI, Gregory, Bernard , CZEKAJ, Mark , COLLIS, Alan, John , VAZ, Roy
IPC分类号： C07K5/06 , C07F9/30 , A61K31/4045 , A61K38/05 , A61P25/00
CPC分类号： C07K5/0827 , A61K38/00 , C07F9/301 , C07F9/303 , C07F9/5727 , C07F9/5728 , C07F9/65037 , C07F9/65067 , C07K5/06191
摘要： The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula (I) wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.
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公开(公告)号：EP0717736A1
公开(公告)日：1996-06-26
申请号：EP94926731.0
申请日：1994-09-12
申请人： NARHEX LIMITED
发明人： GROBELNY, Damian
IPC分类号： C07C243 , C07C251 , C07C255 , C07C271 , C07C281 , C07D207 , C07D209 , C07D211 , C07D213 , C07D215 , C07D231 , C07D237 , C07D239 , C07D243 , C07D245 , C07D255 , C07D257 , C07D265 , C07D295 , C07D303 , C07D307 , C07D401 , C07D403 , C07D405 , C07D471 , C07D487 , C07D491 , C07D495 , C07D498 , C07D521 , C07F9 , C07K5 , A61K38
CPC分类号： C07D237/04 , A61K38/00 , C07C243/18 , C07C243/28 , C07C243/32 , C07C243/34 , C07C251/80 , C07C255/13 , C07C255/24 , C07C271/20 , C07C271/22 , C07C281/02 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07C2603/24 , C07D207/14 , C07D207/416 , C07D209/48 , C07D211/28 , C07D211/58 , C07D211/72 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/75 , C07D213/80 , C07D215/14 , C07D231/04 , C07D231/12 , C07D231/54 , C07D233/56 , C07D237/30 , C07D237/32 , C07D239/04 , C07D243/10 , C07D245/02 , C07D249/08 , C07D255/02 , C07D257/04 , C07D265/06 , C07D265/30 , C07D295/13 , C07D295/26 , C07D303/36 , C07D307/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D495/04 , C07F9/091 , C07F9/093 , C07F9/1411 , C07F9/1412 , C07F9/5532 , C07F9/5721 , C07F9/588 , C07F9/60 , C07F9/62 , C07F9/65067 , C07F9/650994 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65742 , C07F9/65744 , C07K5/06139 , C07K5/06191
摘要： The invention relates to retroviral protease inhibitors of the general formula (I): W-(A)n-B-(A*)m-V where W, A, B, A*, V, n and m are as defined herein, including related prodrugs of general formula (I) comprising a solubilising group which is labile in vivo.
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公开(公告)号：EP0464509B1
公开(公告)日：1995-08-30
申请号：EP91110239.0
申请日：1991-06-21
IPC分类号： C07F9/40 , A61K31/675 , C07F9/38 , C07F9/6506 , C07F9/6512 , C07F9/58 , C07F9/6539 , C07F9/6561 , C07F9/00
CPC分类号： C07F9/588 , C07F9/3873 , C07F9/405 , C07F9/65067 , C07F9/65127 , C07F9/6524 , C07F9/6539 , C07F9/6561
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10.发明公开
公开(公告)号：EP0525629A2
公开(公告)日：1993-02-03
申请号：EP92112568.8
申请日：1992-07-22
申请人： Dr. Karl Thomae GmbH
发明人： Himmelsbach, Frank, Dr. Dipl.-Chem. , Linz, Günter, Dr. Dipl.-Chem. , Austel, Volkhard, Dr. Dipl.-Chem. , Pieper, Helmut, Dr.Dipl.-Chem. , Müller, Thomas, Dr. Dipl.-Chem. , Weisenberger, Johannes, Dr. Dipl.-Chem. , Seewaldt-Becker, Elke, Dr. Dipl.-Biologin
IPC分类号： C07D403/04 , C07D257/04 , C07D233/54 , C07D249/08 , C07D277/30 , C07D263/32 , C07D271/06 , C07D285/12 , C07D233/24 , C07D307/54 , C07D401/14
CPC分类号： C07D233/64 , C07D249/08 , C07D257/04 , C07D263/32 , C07D271/10 , C07D277/30 , C07D285/12 , C07D307/68 , C07D401/04 , C07D403/04 , C07F9/65067
摘要： Die Erfindung betrifft 5-gliedrige Heterocyclen der allgemeinen Formel
in der
X 1 bis X 5 wie im Anspruch 1 definiert sind, deren Tautomere, deren Stereoisomere einschließlich deren Gemische und deren Salze, insbesondere deren physiologisch verträgliche Salze mit anorganischen oder organischen Säuren oder Basen, welche wertvolle pharmakologische Eigenschaften aufweisen, vorzugsweise aggregationshemmende Wirkungen, die Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung.摘要翻译： 本发明涉及通式
在其中X 1至X 5如权利要求1，及其互变异构体中所定义的5元杂环，其立体异构体，包括其混合物和它们的盐，尤其是其生理学上可耐受的无机或有机酸的盐 或碱，其具有有用的药理性质，优选聚集抑制-动作，含有它们的药物和它们的制备过程。
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