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    METHODS FOR INHIBITING COGNITIVE DETERIORATION IN ADULTS WITH DOWN'S SYNDROME
    21.
    发明公开
    METHODS FOR INHIBITING COGNITIVE DETERIORATION IN ADULTS WITH DOWN'S SYNDROME 有权
    VERFAHREN ZUR HEMMUNG DES KOGNITIVEN ABBAUS BEI ERWACHSENEN MIT DOWN-SYNDROM

    公开(公告)号：EP1432379A4

    公开(公告)日：2005-07-13

    申请号：EP02770441

    申请日：2002-08-27

    申请人： CORCEPT THERAPEUTICS INC

    发明人： BELANOFF JOSEPH K

    IPC分类号： A61J1/14 ,  A61K31/05 ,  A61K31/56 ,  A61K31/567 ,  A61K31/569 ,  A61K31/573 ,  A61K31/575 ,  A61K45/00 ,  A61P25/28 ,  A61K6/00

    CPC分类号： A61K31/573 ,  A61K31/56 ,  A61K31/567 ,  A61K31/575

    摘要： This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents capable of inhibiting the binding of cortisol to its receptors can be used in methods for preventing or reversing cognitive deterioration in adults with Down's syndrome. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for preventing or reversing cognitive deterioration in a DS patient including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

    摘要翻译： 本发明一般涉及精神病学领域。 特别地，本发明涉及以下发现：能够抑制皮质醇与其受体结合的药剂可用于预防或逆转唐氏综合症患者的认知恶化的方法。 米非司酮，一种有效的特异性糖皮质激素受体拮抗剂，可用于这些方法。 本发明还提供了用于预防或逆转DS患者的认知恶化的试剂盒，其包括糖皮质激素受体拮抗剂和教导糖皮质激素受体拮抗剂施用的适应症，剂量和时间表的教学材料。

    DIFFERENTIAL DIAGNOSIS OF ECTOPIC CUSHING'S SYNDROME
    27.
    发明公开
    DIFFERENTIAL DIAGNOSIS OF ECTOPIC CUSHING'S SYNDROME 审中-公开

    公开(公告)号：EP3405101A1

    公开(公告)日：2018-11-28

    申请号：EP17741860.5

    申请日：2017-01-18

    申请人： Corcept Therapeutics, Inc.

    发明人： MORAITIS, Andreas G.

    IPC分类号： A61B5/00 ,  G01N33/74

    CPC分类号： G01N33/743 ,  A61B5/4227 ,  G01N33/74 ,  G01N2333/575 ,  G01N2333/723 ,  G01N2800/04 ,  G16H50/30

    摘要： Improved methods and systems for diagnosing and for treating Cushing's syndrome and Cushing's Disease are provided herein, including methods and systems for concurrently treating Cushing's syndrome and differentially diagnosing Cushing's Disease from Ectopic Cushing's Syndrome in a patient with an established diagnosis of ACTH-dependent Cushing's syndrome. Treatment methods can use glucocorticoid receptor antagonists (GRAs), which differentially affect the ratio of cortisol to ACTH levels in patients having Cushing's Disease versus patients having Ectopic Cushing's Syndrome. Methods for concurrently treating and differentially diagnosing Cushing's Disease from Ectopic Cushing's Syndrome include obtaining baseline cortisol and ACTH levels of a patient, treating the patient with a GRA according to a protocol that would typically substantially elevate cortisol levels, obtaining post-treatment cortisol and ACTH levels of the patient, determining a differential relationship between baseline cortisol and ACTH levels and post-treatment cortisol and ACTH levels and providing a positive diagnosis based on the differential relationship.

    SYSTEMS AND METHODS OF MANAGING TREATMENT OF A CHRONIC CONDITION BY SYMPTOM TRACKING
    30.
    发明公开
    SYSTEMS AND METHODS OF MANAGING TREATMENT OF A CHRONIC CONDITION BY SYMPTOM TRACKING 审中-公开
    系统和方法用于管理慢性疾病的治疗BY症状CHASE

    公开(公告)号：EP3143494A2

    公开(公告)日：2017-03-22

    申请号：EP15793415.9

    申请日：2015-05-18

    申请人： Corcept Therapeutics, Inc.

    发明人： LO, Steven ,  PENAKE, David ,  LYONS, John ,  SAGINIAN, Lisa

    IPC分类号： G06F7/06 ,  G06F17/40 ,  G06G7/60 ,  G06Q50/24

    CPC分类号： G16H15/00 ,  A61K31/567 ,  G01N33/492 ,  G06F19/00

    摘要： Devices, systems, and methods for use in managing treatment of a chronic disorder with pharmaceutical or therapeutic compounds by tracking symptoms associated with the disorder. Methods include inputting patient attributes, factors and various and other data relating to the patient in conjunction with one or more symptoms into a symptom tracking system and outputting a report of the data tracked over time to any of the patient, a medical professional and a drug developer to improve identification of a relapse of the chronic condition and improve management of the treatment regimen for any and all patients.

    摘要翻译： 设备，系统，以及用于与通过跟踪与该病症相关的症状的药物或治疗性化合物治疗管理慢性疾病的用途。 方法包括：输入病人属性，影响因素以及各种和其他数据涉及与一种或多种症状相结合病人进入一个症状跟踪系统和输出婷跟踪一段时间内任何病人的数据报告，医学专业的药物 开发商以改善慢性疾病的复发的识别，提高了治疗方案的管理的任何和所有的病人。