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公开(公告)号：EP1371640B1
公开(公告)日：2009-10-28
申请号：EP02705321.4
申请日：2002-03-18
发明人： OGATA, Kazumi , SAKAUE, Takahiro , ITO, Kazuhiko
IPC分类号： C07C323/60 , A61K8/00 , A61K8/42 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61P17/16 , A61P43/00
CPC分类号： A61K31/198 , A61K31/185 , A61K31/195 , A61K31/197 , C07C323/60
摘要： A novel a-lipoic acid derivative represented by the following formula (I). It has tyrosinase inhibitory activity, melanin production inhibitory activity, and elastase inhibitory activity. (I) (In the formula, M represents a metal and A represents an amino acid residue bonded through the nitrogen atom.).
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公开(公告)号：EP1462112B1
公开(公告)日：2009-03-18
申请号：EP02775494.4
申请日：2002-11-05
发明人： MINAGAWA, Yoko , FUJII, Atsuko , YOSHIDA, Yukuo , ONOUE, Satomi, c/o Itoham Central Research Inst. , KASHIMOTO, Kazuhisa, c/o Itoham Central Rch. Inst.
CPC分类号： A61K9/0048 , A61K38/00 , A61K47/42 , C07K14/57563
摘要： Remedies for dry eye and diseases associated with dry eye which contain as the active ingredient peptides represented by the following general formula I or pharmaceutically acceptable salts thereof: H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg- X1-Gln-X2-Ala-Val-X3-X4-Tyr-Leu-X5-X6 I wherein X1, X3 and X4 represent each Lys or Arg X2 represents Met, Leu or nLeu X5 represents a chemical bond, Asn, Asn-Ser, Asn-Ser-Ile, Asn-Ser-Ile-Leu or Asn-Ser-Ile-Leu-Asn-X7 wherein X7 represents a chemical bond, Gly, etc. and X6 represents -OH or -NH2.
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公开(公告)号：EP1029537B1
公开(公告)日：2008-02-20
申请号：EP98950501.1
申请日：1998-11-02
发明人： HIGASHIYAMA, Masayo , OHTORI, Akira
CPC分类号： A61K47/12 , A61K9/0048 , A61K9/08
摘要： Sustained release eyedrops containing a beta -blocker such as carteolol hydrochloride, to which a C3-C7 fatty acid such as sorbic acid has been added so as to enhance the intraocular mobility of the beta -blocker and improve the retention thereof in the ophthalmic tissues.
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公开(公告)号：EP1459743A3
公开(公告)日：2007-12-26
申请号：EP04014078.2
申请日：1999-08-13
发明人： Azuma, Mitsuyoshi , Yoshida, Yukuo , Waki, Mitsunori , Uehata, Masayoshi, c/o Mitsubishi Pharma Corp.
IPC分类号： A61K31/00 , A61K31/437 , A61K31/4409 , A61K31/4545 , A61K31/496 , A61K31/551 , A61P27/06
CPC分类号： A61K31/551 , A61K31/00 , A61K31/437 , A61K31/4409 , A61K31/4545 , A61K31/496 , Y10S514/912 , Y10S514/913
摘要： An agent for the prophylaxis and treatment of glaucoma, which contains a compound having a Rho kinase inhibitory activity, particularly an agent for the prophylaxis and treatment of glaucoma, which contains a compound of the formula (I)
wherein each symbol is as defined in the specification, as the compound having a Rho kinase inhibitory activity, is provided. The agent for the prophylaxis and treatment of glaucoma of the present invention is a novel agent for the prophylaxis and treatment of glaucoma and has intraocular pressure lowering action, optic disc blood flow improving action and aqueous humor outflow promoting action.-
25.发明公开AGENT FOR REPAIRING CORNEAL PERCEPTION 有权2-氯-6,7-二甲氧基 - N-5 [5-（1）H-吲唑基]喹唑啉-4-胺，N-（1-苄基-4-哌啶基）-1H-吲唑-5-胺二盐酸盐， 4- [2-（2,3,4,5,6-五氟苯基）丙烯酰基]肉桂酸和法舒地尔盐酸盐在角膜感知的恢复中使用。
公开(公告)号：EP1616577A1
公开(公告)日：2006-01-18
申请号：EP04728020.1
申请日：2004-04-16
IPC分类号： A61K45/00 , A61K38/00 , A61K31/517 , A61P27/02
CPC分类号： A61K38/45 , A61K31/454 , A61K31/517 , C12Y304/22054
摘要： The present invention provides a novel pharmaceutical agent for recovering corneal sensitivity after corneal surgery and improving symptoms of dry eye. This pharmaceutical agent is useful for improving decreased corneal sensitivity and dry eye associated with corneal neurodegeneration such as post-cataract operation, post-LASIK operation, post-PRK operation, postkeratoplasty operation, neuroparalytic keratopathy, corneal ulcer, diabetic keratopathy and the like, since it contains a Rho protein inhibitor.
摘要翻译： 本发明提供了用于角膜手术后恢复角膜敏感性和改进干眼症状的新的药剂。 此药剂是用于提高角膜敏感性降低和角膜神经变性有关的干眼病有用：如白内障手术后，后LASIK手术，后PRK手术，postkeratoplasty手术，神经麻痹性角膜病，角膜溃疡，糖尿病性角膜病等，由于 它含有的Rho蛋白抑制剂。
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26.发明公开PERCUTANEOUS ABSORPTION PREPARATION FOR TREATING OPHTHALMIC DISEASE, USE THEREOF AND METHOD FOR MIGRATION OF OPHTHALMIC REMEDY INTO TOPICAL TISSUE IN EYE 有权透皮吸收制剂用于在眼睛的局部用制备组织迁移的眼睛治疗眼疾，它的用途和方法
公开(公告)号：EP1591110A1
公开(公告)日：2005-11-02
申请号：EP04704362.5
申请日：2004-01-22
发明人： KAWAHARA, Kohji; c/o NICHIBAN CO., LTD. , ARAMOMI, Yasuhiko; c/o NICHIBAN CO., LTD. , OHTORI, Akira; , ISOWAKI, Akiharu
CPC分类号： A61K9/7053 , A61K9/0048 , A61K9/7076
摘要： A transdermal drug delivery system for treatment of ophthalmic diseases comprising a structure that a plaster layer containing a remedy for ophthalmic diseases is provided on a support, wherein the system is applied to a skin surface including a front surface of an eyelid to administer the remedy for ophthalmic diseases in the plaster layer to an ophthalmic topical tissue by percutaneous permeation substantially without being administered through a systemic blood flow. Use of the transdermal drug delivery system for treatment of ophthalmic diseases, comprising applying the transdermal drug delivery system to a skin surface including a front surface of an eyelid to transfer the remedy for ophthalmic diseases in the plaster layer to an ophthalmic topical tissue by percutaneous permeation substantially without being administered through a systemic blood flow, and a method for transferring the remedy for ophthalmic diseases to the ophthalmic topical tissue.
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公开(公告)号：EP1566184A1
公开(公告)日：2005-08-24
申请号：EP03758790.4
申请日：2003-10-22
摘要： The present invention provides a new type of pharmaceutical agent that recovers corneal sensitivity after corneal surgery or improves the condition of dry eye. Application of a somatostatin receptor agonist is expected to provide an improvement effect on decreased corneal sensitivity after cataract surgery or LASIK surgery, decreased corneal sensitivity and dry eye associated with corneal neurodegeneration such as neuroparalytic keratopathy, corneal ulcer, diabetic keratopathy and the like.
摘要翻译： 本发明提供了在角膜手术后恢复角膜敏感性或改善干眼症状的新型药剂。 预期生长抑素受体激动剂的应用对于白内障手术或LASIK手术后的角膜敏感性降低，与角膜神经变性如神经麻痹性角膜病，角膜溃疡，糖尿病性角膜病等相关的角膜敏感性和干性眼睛的降低有改善作用。
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28.发明公开NOVEL ALPHA-KETOAMIDE DERIVATIVE AND USE THEREOF 有权NEER ALPHA-KETOAMIDDERIVATE UND DEREN VERWENDUNG
公开(公告)号：EP1557407A1
公开(公告)日：2005-07-27
申请号：EP03765283.1
申请日：2003-07-11
发明人： NAKAMURA, Masayuki , INOUE, Jun
IPC分类号： C07C311/19 , A61K31/18 , A61P7/02 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P37/02 , A61P43/00
CPC分类号： C07C311/19
摘要： The present invention provides a compound represented by the formula (I):
wherein R 1 , R 2 and R 3 each represents a lower alkyl group.摘要翻译： 本发明提供由式（I）表示的化合物：其中R 1，R 2和R 3各自表示低级烷基。
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29.发明公开
公开(公告)号：EP1525884A1
公开(公告)日：2005-04-27
申请号：EP03771445.8
申请日：2003-07-30
发明人： HIGASHIYAMA, Masayo
IPC分类号： A61K31/4545 , A61K9/08 , A61K47/02 , A61P11/02 , A61P17/04 , A61P27/02 , A61P27/14 , A61P37/08 , A61P43/00
CPC分类号： A61K31/4545 , A61K9/0043 , A61K9/0048 , A61K47/02
摘要： An aqueous liquid preparation containing (+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butyric acid or a pharmacologically acceptable acid addition salt thereof, which is stabilized with a water-soluble metal chloride, is provided.
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公开(公告)号：EP1491537A8
公开(公告)日：2005-03-30
申请号：EP03745432.9
申请日：2003-03-27
发明人： NAKAMURA, Masayuki , INOUE, Jun
IPC分类号： C07D265/32 , A61K31/5375 , A61P9/00 , A61P9/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P37/02 , A61P43/00
CPC分类号： A61K31/5375 , C07D265/32
摘要： A compound represented by the following formula (I) wherein R 1 and R 2 are each a lower alkyl group optionally having substituents, which has a calpain inhibitory activity, or a salt thereof is provided.
摘要翻译： 提供下式（I）表示的化合物或其盐，其中R1和R2各自是任选具有取代基的具有钙蛋白酶抑制活性的低级烷基或其盐。
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