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公开(公告)号：EP1371640B1
公开(公告)日：2009-10-28
申请号：EP02705321.4
申请日：2002-03-18
发明人： OGATA, Kazumi , SAKAUE, Takahiro , ITO, Kazuhiko
IPC分类号： C07C323/60 , A61K8/00 , A61K8/42 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61P17/16 , A61P43/00
CPC分类号： A61K31/198 , A61K31/185 , A61K31/195 , A61K31/197 , C07C323/60
摘要： A novel a-lipoic acid derivative represented by the following formula (I). It has tyrosinase inhibitory activity, melanin production inhibitory activity, and elastase inhibitory activity. (I) (In the formula, M represents a metal and A represents an amino acid residue bonded through the nitrogen atom.).
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公开(公告)号：EP1371640A1
公开(公告)日：2003-12-17
申请号：EP02705321.4
申请日：2002-03-18
发明人： OGATA, Kazumi , SAKAUE, Takahiro , ITO, Kazuhiko
IPC分类号： C07C323/60 , A61K7/00 , A61K7/42 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61P17/16 , A61P43/00
CPC分类号： A61K31/198 , A61K31/185 , A61K31/195 , A61K31/197 , C07C323/60
摘要： Provided are novel α-lipoic acid derivatives represented by the following formula (I), which have a tyrosinase inhibiting activity, a melanin production suppressing activity and an elastase inhibiting activity.
(In the formula, M denotes a metal, and A denotes an amino acid which is bound via N.)摘要翻译： 提供具有酪氨酸酶抑制活性，黑色素产生抑制活性和弹性蛋白酶抑制活性的由下式（I）表示的新型α-硫辛酸衍生物。
（式中，M表示金属，A表示通过N结合的氨基酸。） -
公开(公告)号：EP1043322B1
公开(公告)日：2002-05-08
申请号：EP98961437.5
申请日：1998-12-18
发明人： OGATA, Kazumi , NAKAO, Hidetoshi , ITO, Kazuhiko , SAKAUE, Takahiro , IEMURA, Masahito , INOUE, Yutaka
IPC分类号： C07D311/72 , C07D405/12 , C07K5/02 , A61K31/355 , A61K31/40 , A61K38/05 , A61K38/06 , A61K7/00 , A61P1/16
CPC分类号： C07D405/12 , A61K8/678 , A61K38/00 , A61Q19/00 , C07D311/72 , C07K5/0215
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公开(公告)号：EP1054003A1
公开(公告)日：2000-11-22
申请号：EP99902828.5
申请日：1999-02-03
IPC分类号： C07D233/64 , C07D403/06 , C07D417/04 , A61K31/415 , A61K31/495 , A61K31/505
CPC分类号： C07D233/64 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/04 , C07D417/12
摘要： Urocanic acid derivatives useful as antiallergic agents represented by the following formula (I) or a pharmacologically acceptable salt thereof:
wherein R 2 denotes hydrogen or lower alkyl, R 3 denotes nitro, amino, cyano or COOR 2 , wherein R 2 in said COOR 2 is as defined above, and Q denotes carbon or nitrogen.摘要翻译： 可用作下式（I）所示的抗过敏剂的尿刊酸衍生物或其药理学上可接受的盐：其中R2表示氢或低级烷基，R3表示硝基，氨基，氰基或COOR2，其中所述COOR2中的R2如上所定义， Q表示碳或氮。
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公开(公告)号：EP1043322A1
公开(公告)日：2000-10-11
申请号：EP98961437.5
申请日：1998-12-18
发明人： OGATA, Kazumi , NAKAO, Hidetoshi , ITO, Kazuhiko , SAKAUE, Takahiro , IEMURA, Masahito , INOUE, Yutaka
IPC分类号： C07D311/72 , C07D405/12 , C07K5/02 , A61K31/355 , A61K31/40 , A61K38/05 , A61K38/06 , A61K7/00
CPC分类号： C07D405/12 , A61K8/678 , A61K38/00 , A61Q19/00 , C07D311/72 , C07K5/0215
摘要： Novel vitamin E derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which are useful as hepatopathy inhibitors, anticataract agents, cerebral metabolism activators, antioxidants and cosmetic components. In Formula (I), R 1 and R 2 are the same or different and each represents hydrogen or methyl; R 3 represents an SH compound bonded via an S-bond selected from among glutathione, γ-glutamylcysteine, cysteine, penicillamine, esters thereof and cysteamine, and R 4 represents hydroxy, an N-substituted amino acid selected from among glycine, β-alanine, γ-aminobutyric acid, 5-aminovaleric acid, ε-aminocaproic acid, anthranilic acid, tranexamic acid, proline, esters thereof, aminoethylsulfonic acid and aminoethylsulfinic acid, or serotonin.
摘要翻译： 由通式（I）表示的新型维生素E衍生物或其药理学上可接受的盐，其可用作肝病抑制剂，抗龋齿剂，脑代谢活化剂，抗氧化剂和美容成分。 在式（I）中，R 1和R 2相同或不同，各自表示氢或甲基; R3表示通过选自谷胱甘肽，γ-谷氨酰半胱氨酸，半胱氨酸，青霉胺，其酯和半胱胺中的S-键键合的SH化合物，R4表示羟基，选自甘氨酸，β-丙氨酸，γ-氨基丁酸的N-取代氨基酸 氨基丁酸，5-氨基戊酸，ε-氨基己酸，邻氨基苯甲酸，氨甲环酸，脯氨酸，其酯，氨基乙基磺酸和氨基乙基亚磺酸，或5-羟色胺。
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