公开(公告)号：EP3082889A1

公开(公告)日：2016-10-26

申请号：EP14825051.7

申请日：2014-12-18

申请人： Acist Medical Systems, Inc.

发明人： ZELENKA, Robert

IPC分类号： A61L29/04 ,  A61L29/08 ,  A61L29/14 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61B8/445 ,  A61B8/12 ,  A61L29/041 ,  A61L29/048 ,  A61L29/085 ,  A61L29/14 ,  A61L31/048 ,  A61L31/10 ,  A61L31/14 ,  C08L23/06

摘要： A catheter is disclosed comprising a sheath surrounding an inner lumen. The inner lumen is configured to receive a fluid. The sheath includes a sheath portion that comprises a hydrophilic material, wherein the hydrophilic material is in direct contact with the fluid. The hydrophilic material helps resist formation of air bubbles along the inner lumen.

公开(公告)号：EP2762191A4

公开(公告)日：2015-04-15

申请号：EP12835108

申请日：2012-09-24

申请人： TERUMO CORP

发明人： FUJITA YOTARO ,  ONISHI MAKOTO ,  MAEDA NAOYUKI

IPC分类号： A61M25/10 ,  A61L29/00

CPC分类号： A61L29/06 ,  A61L29/048 ,  A61M25/1029 ,  A61M29/02 ,  A61M2025/1075 ,  C08L77/00

公开(公告)号：EP2163268B1

公开(公告)日：2014-01-22

申请号：EP07816530.5

申请日：2007-10-10

申请人： Lepu Medical Technology (Beijing) CO., LTD.

发明人： YU, Zhanjiang

IPC分类号： A61L27/22 ,  A61L31/16 ,  A61F2/02 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04

CPC分类号： A61L31/047 ,  A61L27/227 ,  A61L27/54 ,  A61L29/048 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/256

公开(公告)号：EP2379124A2

公开(公告)日：2011-10-26

申请号：EP09799190.5

申请日：2009-11-27

申请人： University College Cork, National University of Ireland, Cork

发明人： CAPLICE, Noel

IPC分类号： A61L31/16

CPC分类号： A61L29/048 ,  A61L29/16 ,  A61L2300/414 ,  A61L2300/602

摘要： Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25pg to 950pg of IGF-1 directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.

摘要翻译： 本文提供了治疗患有（患有）急性心肌梗死的个体和用于治疗这些个体的药物洗脱支架的个体的方法。 这些方法包括通过例如通过手术插入在急性心肌梗死部位上游的急性冠状动脉闭塞部位的药物洗脱支架（DES）进行治疗，该药物洗脱支架能够从25pg-950pg IGF-1直接进入冠状动脉循环。 该治疗特别针对刺激受损的心肌或左心室重塑的修复或存活。

公开(公告)号：EP2344521A2

公开(公告)日：2011-07-20

申请号：EP09740951.0

申请日：2009-09-23

申请人： Tel HaShomer Medical Research Infrastructure and Services Ltd.

发明人： ZLOTKIN, Amir ,  KESTENBOIM, Hen

IPC分类号： C07K7/06

CPC分类号： C07K14/43595 ,  A61L27/227 ,  A61L27/34 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  C02F1/50 ,  C02F3/34 ,  C02F2303/20 ,  C07K7/06 ,  C07K7/08 ,  C07K14/415 ,  C07K14/461 ,  C09D5/1625

摘要： Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY, YDYNLY, FDYNFY, FDYNLY, FDYNWY, YDWNLY, YDWHLY, and WDYNLY, extracted from organisms such as aquatic organisms and moss or any other sequence described herein, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.

摘要翻译： 组合物包含分离的肽的，其可以例如任选地包含选自YDYNWY，YDYNLY，FDYNFY，FDYNLY，FDYNWY，YDWNLY，YDWHLY和WDYNLY，从生物体提取的所选择的序列：如水生生物和藓类或者任何其它序列 描述中，并使用相同的，包括用于治疗或预防微生物形成的生物膜和打击到表面的细胞的粘附的方法。

公开(公告)号：EP1919494A2

公开(公告)日：2008-05-14

申请号：EP06849801.3

申请日：2006-07-21

申请人： The Regents of the University of Colorado, A Body Corporate ,  University of Alberta

发明人： HODGES, Robert S. ,  IRVIN, Randall T. ,  GILTNER, Carmen ,  VAN SCHAIK, Erin

IPC分类号： A61K38/16

CPC分类号： A61K38/164 ,  A61L12/14 ,  A61L27/227 ,  A61L27/54 ,  A61L29/048 ,  A61L29/16

摘要： The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.

公开(公告)号：EP1748805A1

公开(公告)日：2007-02-07

申请号：EP05746512.2

申请日：2005-05-25

申请人： Biointeractions Ltd.

发明人： LUTHRA, Ajay Kumar ,  SANDHU, Shivpal Singh

IPC分类号： A61L27/22 ,  A61L27/34 ,  A61L27/54

CPC分类号： A61L29/16 ,  A61L27/22 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2300/606 ,  C08L77/04

摘要： Biocompatible carrier materials are described herein for enhanced delivery of therapeutic agents. Embodiments include materials and methods for making a biodegradable coating on a surface of a medical device by forming a biodegradable layer on at least a portion of the surface of the medical device, the layer comprising a copolymer and a therapeutic agent releasable into a patient after implantation of the device into the patient, wherein the copolymer is a polyamino acid derivatized to have a hydrophobic hydrocarbon side chain that has a molecular weight from about 14 to about 5000. One embodiment is a polypeptide that includes at least one amino acid that has been modified to include a hydrophobic side chain. The number and type of amino acids and hydrophobic side chains may be altered to adjust the solubility of the material in solvents, and to control the hydrophobic-to-hydrophobic balance of the coatings made with the materials, so as to enhance therapeutic agent delivery. And hydrophilic groups may also be introduced as a further means to adjust the material’s property.

公开(公告)号：EP1051208A1

公开(公告)日：2000-11-15

申请号：EP99905536.1

申请日：1999-01-29

申请人： ADVANCED CARDIOVASCULAR SYSTEMS, INC.

发明人： MICHAL, Eugene, T. ,  BUCHKO, Christopher, J. ,  BIGUS, Stephen, J.

IPC分类号： A61L29/00 ,  A61L31/00

CPC分类号： A61L31/10 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L2420/02 ,  A61L2420/08 ,  A61M2025/0056 ,  C08L89/00

摘要： A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and a salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.

公开(公告)号：EP0395375B1

公开(公告)日：1996-08-21

申请号：EP90304432.9

申请日：1990-04-25

申请人： KNOLL AG

发明人： Gray, John Gordon, Jr. ,  Parikh, Indu

IPC分类号： C12N15/57 ,  C12N1/11 ,  C12N5/10 ,  C12N9/64 ,  A61K38/46 ,  A61L27/00

CPC分类号： C12N9/6418 ,  A61K35/58 ,  A61K38/00 ,  A61L27/227 ,  A61L29/048

摘要： The present invention relates to novel DNA sequences which encode polypeptides displaying the activity of ancrod and to recombinant DNA molecules which comprise them. The invention also relates to hosts transformed with these DNA molecules as well as to the recombinant polypeptides expressed by them. This invention further relates to pharmaceutically effective compositions and methods which employ these recombinant polypeptides.

公开(公告)号：EP0494216A1

公开(公告)日：1992-07-15

申请号：EP90914567.0

申请日：1990-09-27

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： HUBBELL, Jeffrey, A. ,  MASSIA, Stephen, P. ,  DESAI, Neil, P.

IPC分类号： A61L27 ,  A61L17 ,  A61L29 ,  A61L31 ,  C07K17 ,  C12M3 ,  C12N5 ,  C12N11

CPC分类号： C12N5/0068 ,  A61L17/145 ,  A61L27/227 ,  A61L27/34 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  C07K17/08 ,  C12N2533/50 ,  C08L89/00

摘要： On a mis au point une surface d'adhérence de cellules indépendante des protéines absorbées. La surface traitée comprend une matière transformée chimiquement à laquelle des petits peptiddes, comportant moins de 12 restes d'acide aminé et comprenant une séquence d'acides aminés YIGSR, RGD ou REDV, sont liés de manière covalente. Les peptides de l'invention comprennent un acide aminé de glycine terminal. L'activation à l'aide de chlorure de trésyle de fractions hydroxyles de surface permet d'obtenir les cites de surfaces actifs au moyen desquels un bras de glycine terminal d'un peptide sélectionné se fixe afin de former des liaisons covalentes entre le substrat et le peptide. On peut citer à titre d'exemple de surfaces pouvant être utilisées conjointement avec l'invention, des surfaces polymères, métalliques et céramiques. Le procédé de l'invention comprend également un procédé de prétraitement ménageant des fractions hydroxyles destinées à des surfaces dépourvues de fractions hydroxyles facilement disponibles. Les procédés de préparation des surfaces traitées sont également compris dans l'invention. Sont également compris des dispositifs d'implants biomédicaux traités en surface ainsi que des dispositifs de culture de cellules. La surface traitée favorise un rythme et une quantité accrue d'adhérence des cellules sur la surface, indépendamment des concentrations de sérum de milieux ou d'autres protéines absorbées. L'invention concerne en outre des substrats polymères dont la surface comporte des chaînes de polymères solubles dans l'eau, s'interpénétrant physiquement, ainsi que des procédés permettant leur production.