公开(公告)号：EP3362084A1

公开(公告)日：2018-08-22

申请号：EP16790785.6

申请日：2016-10-13

申请人： Alcresta Therapeutics, Inc.

发明人： GALLOTTO, Robert ,  LORING, Greta, L. ,  GARY, Kenneth ,  PARK, Edward, S. ,  BROWN, David, J. ,  SCHOEVAART, Willem Robert, Klaas ,  VAN VLIET, Michiel Christian, Alexander

IPC分类号： A61K38/46 ,  A61K9/00 ,  A61M5/14 ,  A61M5/142

CPC分类号： A61K31/202 ,  A23L33/00 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0076 ,  A61L29/048 ,  A61M5/14 ,  A61M5/1413 ,  A61M5/142 ,  C12N9/20 ,  C12N11/06 ,  C12N11/08

摘要： Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.

公开(公告)号：EP2789626B1

公开(公告)日：2018-07-18

申请号：EP14153264.8

申请日：2009-09-23

申请人： Tel HaShomer Medical Research Infrastructure and Services Ltd.

发明人： Zlotkin, Amir ,  Kestenboim, Hen

IPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/415 ,  C07K14/435 ,  C02F1/00 ,  C09D5/16 ,  A61L31/16 ,  C07K14/46

CPC分类号： C07K14/43595 ,  A61L27/227 ,  A61L27/34 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  C02F1/50 ,  C02F3/34 ,  C02F2303/20 ,  C07K7/06 ,  C07K7/08 ,  C07K14/415 ,  C07K14/461 ,  C09D5/1625

摘要： Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY, YDYNLY, FDYNFY, FDYNLY, FDYNWY, YDWNLY, YDWHLY, and WDYNLY, extracted from organisms such as aquatic organisms and moss or any other sequence described herein, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.

公开(公告)号：EP1983927B1

公开(公告)日：2014-11-05

申请号：EP07750987.5

申请日：2007-02-15

申请人： Wake Forest University Health Sciences

发明人： VAN DYKE, Mark E.

IPC分类号： A61L27/34 ,  A61L31/10 ,  A61L15/32 ,  A61L27/22 ,  A61L29/04 ,  A61L29/08 ,  A61L26/00 ,  A61L31/04

CPC分类号： A61L33/128 ,  A61K38/1748 ,  A61L15/32 ,  A61L26/0047 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0041 ,  A61L2300/42 ,  A61L2300/424 ,  C07K1/36 ,  C07K14/4741 ,  C08L89/04

公开(公告)号：EP2796146A1

公开(公告)日：2014-10-29

申请号：EP14168366.4

申请日：2006-02-24

申请人： University of Utah Research Foundation

发明人： Li, Dean Y. ,  Wilson, Brent D. ,  Brunhart, Lise Sorensen

IPC分类号： A61K38/39 ,  A61L31/16 ,  A61L33/00 ,  A61P7/02 ,  A61P9/00 ,  A61L27/34 ,  A61L27/38 ,  A61L27/22 ,  A61L27/54 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10

CPC分类号： A61L31/16 ,  A61K38/39 ,  A61L27/227 ,  A61L27/34 ,  A61L27/3808 ,  A61L27/3895 ,  A61L27/54 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/047 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/61 ,  A61L2400/18 ,  A61N1/362 ,  A61N1/3956 ,  C08L89/00

摘要： The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cells.

摘要翻译： 本发明提供了促进内皮细胞粘附或迁移的方法，组合物和装置。

公开(公告)号：EP2714719A2

公开(公告)日：2014-04-09

申请号：EP12732869.8

申请日：2012-05-31

申请人： Hutchison Biofilm Medical Solutions Limited

发明人： ZLOTKIN, Amir

IPC分类号： C07K7/08 ,  A61K38/10 ,  A61L27/22 ,  A61L31/10 ,  A61L31/16 ,  C02F1/50 ,  C07K14/435 ,  C09D5/16

CPC分类号： A01N63/02 ,  A61K38/00 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/404 ,  C07K7/08 ,  C07K14/43595 ,  C07K14/47 ,  C09D5/1625 ,  C09D5/1687

摘要： Compositions comprising a protein or isolated peptide, and methods using the same for preventing, dispersing or detaching a biofilm, are disclosed.

公开(公告)号：EP2310035A4

公开(公告)日：2012-08-01

申请号：EP09770772

申请日：2009-06-16

申请人： UNIV ROCHESTER

发明人： OKUNIEFF PAUL ,  ZHANG LURONG

IPC分类号： A61B17/12 ,  A61K38/18 ,  A61L27/00 ,  A61L31/16 ,  A61P39/00 ,  C07K14/50

CPC分类号： A61K38/1825 ,  A61B17/1214 ,  A61B17/1215 ,  A61K38/196 ,  A61L27/227 ,  A61L27/54 ,  A61L29/048 ,  A61L29/16 ,  A61L31/047 ,  A61L31/16 ,  A61L2300/25 ,  C07K14/503 ,  A61K2300/00

公开(公告)号：EP0395375A1

公开(公告)日：1990-10-31

申请号：EP90304432.9

申请日：1990-04-25

申请人： KNOLL AG

发明人： Gray, John Gordon, Jr. ,  Parikh, Indu

IPC分类号： C12N15/57 ,  C12N1/11 ,  C12N5/10 ,  C12N9/64 ,  A61K38/46 ,  A61L27/00

CPC分类号： C12N9/6418 ,  A61K35/58 ,  A61K38/00 ,  A61L27/227 ,  A61L29/048

摘要： The present invention relates to novel DNA sequences which encode polypeptides displaying the activity of ancrod and to recombinant DNA molecules which comprise them. The invention also relates to hosts transformed with these DNA molecules as well as to the recombinant polypeptides expressed by them. This invention further relates to pharmaceutically effective compositions and methods which employ these recombinant polypeptides.

摘要翻译： 本发明涉及编码多肽显示安克洛酶和涉及包含这些重组DNA分子的活性的新的DNA序列。 因此，本发明涉及用DNA合成分子以及由它们中过表达重组多肽转化的宿主。 本发明还涉及药学上有效的组合物和方法，其采用重组多肽的合成。

公开(公告)号：EP2211887B1

公开(公告)日：2018-03-21

申请号：EP08843011.1

申请日：2008-10-17

申请人： Affinergy, Inc. ,  Synthes GmbH

发明人： DARBY, Martyn, K. ,  SANFORD, Isaac, G. ,  BENSON, R., Edward ,  GRON, Hanne ,  HAMILTON, Paul, T. ,  NAIR, Shrikumar, A. ,  BUECHTER, Doug ,  GRUSKIN, Elliott

IPC分类号： A61K38/00 ,  A61L27/22 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/08 ,  C07K7/08 ,  C07K7/06

CPC分类号： C07K7/06 ,  A61L27/227 ,  A61L27/28 ,  A61L27/54 ,  A61L29/048 ,  A61L29/08 ,  A61L29/16 ,  A61L31/047 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/406 ,  C07K7/08 ,  C07K14/001 ,  C07K2319/00

摘要： The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.

公开(公告)号：EP3047861B1

公开(公告)日：2017-10-18

申请号：EP16152830.2

申请日：2009-11-27

申请人： University College Cork-National University of Ireland, Cork

发明人： Caplice, Noel

IPC分类号： A61L29/04 ,  A61L29/16

CPC分类号： A61L29/048 ,  A61L29/16 ,  A61L2300/414 ,  A61L2300/602

摘要： Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25pg to 950pg of IGF-1 directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.

公开(公告)号：EP2762191B1

公开(公告)日：2017-07-12

申请号：EP12835108.7

申请日：2012-09-24

申请人： Terumo Kabushiki Kaisha

发明人： FUJITA, Yotaro ,  ONISHI, Makoto ,  MAEDA, Naoyuki

IPC分类号： A61M25/10 ,  A61L29/00

CPC分类号： A61L29/06 ,  A61L29/048 ,  A61M25/1029 ,  A61M29/02 ,  A61M2025/1075 ,  C08L77/00