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28 条记录 (耗时 0.017 秒)

    VIRAL LATENCY MODEL
    23.
    发明授权
    VIRAL LATENCY MODEL 有权
    VIRUSLATENZMODELL

    公开(公告)号：EP2170369B1

    公开(公告)日：2012-05-23

    申请号：EP08773368.9

    申请日：2008-06-06

    申请人： Universiteit Gent

    发明人： DE REGGE, Nick ,  FAVOREEL, Herman ,  NAUWYNCK, Hans

    IPC分类号： A61K38/19 ,  A61K38/21 ,  C12N5/0793 ,  A61P31/22

    CPC分类号： A61K38/212 ,  C12N5/0619 ,  C12N2501/24 ,  C12N2710/16611

    摘要： The invention relates generally to the field of virology. More particularly, the present invention relates to in vitro models for viral latency. In particular to latently infected cultures of primary and continuous cell lines, and to the use thereof in methods to identify anti-viral compounds. More in particular to identify compounds which are either able to modulate the induction of viral latency in the aforementioned cell cultures, or which are able to retain the viruses in the aforementioned cells in their latent form. Other aspects of the invention are directed to antiviral compounds identified using the models and methods of the present invention, as well as to the use thereof in treating latent infections such as for example latent Herpes Simplex Virus (HSV) infections.

    VIRAL LATENCY MODEL
    24.
    发明公开
    VIRAL LATENCY MODEL 有权
    病毒潜伏期模型

    公开(公告)号：EP2170369A2

    公开(公告)日：2010-04-07

    申请号：EP08773368.9

    申请日：2008-06-06

    申请人： Universiteit Gent

    发明人： DE REGGE, Nick ,  FAVOREEL, Herman ,  NAUWYNCK, Hans

    IPC分类号： A61K38/19 ,  A61K38/21 ,  C12N5/06 ,  A61P31/22

    CPC分类号： A61K38/212 ,  C12N5/0619 ,  C12N2501/24 ,  C12N2710/16611

    摘要： The invention relates generally to the field of virology. More particularly, the present invention relates to in vitro models for viral latency. In particular to latently infected cultures of primary and continuous cell lines, and to the use thereof in methods to identify anti-viral compounds. More in particular to identify compounds which are either able to modulate the induction of viral latency in the aforementioned cell cultures, or which are able to retain the viruses in the aforementioned cells in their latent form. Other aspects of the invention are directed to antiviral compounds identified using the models and methods of the present invention, as well as to the use thereof in treating latent infections such as for example latent Herpes Simplex Virus (HSV) infections.

    METHOD FOR DETECTION OF CANCER CELLS USING VIRUS
    25.
    发明公开
    METHOD FOR DETECTION OF CANCER CELLS USING VIRUS 有权
    方法检测癌细胞利用病毒

    公开(公告)号：EP1979000A4

    公开(公告)日：2009-03-25

    申请号：EP06847911

    申请日：2006-12-21

    申请人： SLOAN KETTERING INST CANCER

    发明人： FONG YUMAN ,  ADUSUMILLI PRASAD

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6897 ,  A61K35/13 ,  C12N2710/16611 ,  C12N2710/24111 ,  G01N33/574

    摘要： The invention relates to compositions and methods for cancer cell detection in bodily samples wherein a cancer cell can be detected within a mixed population of cancer cells and non-cancer cells. The invention also relates to compositions and methods that may be used in cancer cell detection, specifically viruses that are replication-competent conditional to a cancer cell, in particular an oncolytic herpes virus, such as NV 1066 and a vaccinia virus, such as GLV-lh68. Provided are methods and kits for using these viruses that preferentially replicate in cancer cells and may also preferentially infect cancer cells for specific identification of such cancer cells, even when a cancer cell is present, for example, at a ratio of one infected cancer cell in a background often thousand non-cancer cells, thus further providing a reproducible and sensitive screening method for cancer detection, monitoring and prognosis.