公开(公告)号：EP3158311A1

公开(公告)日：2017-04-26

申请号：EP15731036.8

申请日：2015-06-19

申请人： Medizinische Hochschule Hannover ,  Laser Zentrum Hannover E.V.

发明人： KÜHNEL,Mark ,  KELLNER, Manuela ,  JONIGK, Danny ,  IZYKOWSKI, Nicole ,  MEYER, Heiko ,  LORBEER, Raoul-Amadeus ,  HEIDRICH, Marko

IPC分类号： G01N1/30 ,  G01N1/42

CPC分类号： G01N1/36 ,  C12Q1/68 ,  G01N1/286 ,  G01N1/30 ,  G01N1/44 ,  G01N2001/2886 ,  G01N2001/305 ,  G01N2001/364 ,  G06K9/00134 ,  G06K9/0014

摘要： In a first aspect, the invention relates to the use of a UV-polymerizable composition as an embedding medium for biological samples. The UV-polymerizable composition is a composition with a refractive index ranging from n = 1.45 to n = 1.6 after a polymerization process. In another aspect, the invention relates to a method for producing embedded biological samples using said UV-polymerizable composition and to the embedded biological samples themselves. The biological samples can be used in a wide variety of areas, such as diagnostics among others, and are suitable in particular for RNA-based diagnostics.

摘要翻译： 在第一方面，本发明涉及到使用紫外线进行聚合的组合物作为在生物样品包埋介质。 UV可聚合的组合物是具有折射率为N = 1:45到n = 1.6的聚合工艺之后的组合物。 在另一个方面，本发明涉及一种用于制造使用所述紫外可聚合组合物包埋的生物样品，并嵌入生物样品本身。 所述生物样品可以在广泛的领域，颜色可用于：例如，尤其是诊断程序，并特别适合于基于RNA的诊断。

公开(公告)号：EP2439510B1

公开(公告)日：2016-12-07

申请号：EP11184080.7

申请日：2011-10-06

申请人： Synovation B.V.

发明人： Kusters, Ronald Johannes Wilhelmus ,  Van Dijk, Maricus Johannes

IPC分类号： G01N1/36 ,  G01N1/31

CPC分类号： G01N1/36 ,  G01N2001/315 ,  G01N2001/366

公开(公告)号：EP1337831B1

公开(公告)日：2016-11-16

申请号：EP01997686.9

申请日：2001-10-26

申请人： Ventana Medical Systems, Inc.

发明人： CHRISTENSEN, Kimberly ,  MACREA, Ethel, R. ,  SEBASTIAO, Noemi ,  WARD, Glen, D.

IPC分类号： G01N1/36 ,  G01N1/30

CPC分类号： G01N1/36 ,  Y10T436/107497 ,  Y10T436/25125 ,  Y10T436/25375

公开(公告)号：EP1146817B1

公开(公告)日：2016-11-16

申请号：EP98951995.4

申请日：1998-10-05

申请人： BioPath Automation, L.L.C.

发明人： WILLIAMSON, Warren, N. ,  WHITLACH, Stephen ,  DINOVO, Dominic ,  ALLEN, Douglas ,  WARD, Thomas

IPC分类号： G01N1/28 ,  G01N1/36

CPC分类号： G01N1/36 ,  B01L3/502 ,  G01N1/06 ,  G01N1/30 ,  G01N1/31 ,  G01N2001/315 ,  G01N2001/366

公开(公告)号：EP2623950B1

公开(公告)日：2016-10-05

申请号：EP13166072.2

申请日：2007-08-15

申请人： Cytyc Corporation

发明人： Hutchins, Timothy ,  Watts, Hal ,  Scampini, Steven ,  Grimes, Eric ,  Fischer, Andrew

IPC分类号： G01N1/36 ,  C12M1/12

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

公开(公告)号：EP3066194A1

公开(公告)日：2016-09-14

申请号：EP14802752.7

申请日：2014-11-05

申请人： Life Technologies Corporation

发明人： LAU, Aron ,  SHAHBAZIAN, Mona ,  SCHOENBRUNNER, Erhard

IPC分类号： C12N5/078 ,  G01N1/30 ,  G01N1/36

CPC分类号： G01N1/30 ,  G01N1/36 ,  G01N2001/305

摘要： This specification relates to Formalin-fixed embedded quality control material containing a bulking agent for use for validation, verification, and to nm controls for molecular assays. The quality control material can be used for a variety of tissues and for a variety of molecular assays. The quality control material can be used in commercial labs for validation and limit-of-detection analyses.

公开(公告)号：EP2918988A4

公开(公告)日：2016-07-06

申请号：EP13852556

申请日：2013-11-05

申请人： SAKURA FINETEK JAPAN CO LTD

发明人： ENOMOTO JYUNYA ,  MURAKAMI SEIGO ,  NAKAGAWA NOBUYUKI

IPC分类号： G01N1/06 ,  B65G1/04 ,  B65G1/10 ,  B65G1/127 ,  G01N1/31 ,  G01N1/36 ,  G01N35/04

CPC分类号： G01N1/36 ,  G01N1/06 ,  G01N1/312 ,  G01N2035/0441

摘要： Provided is a block storage device including: a magazine (2) which accommodates embedding blocks (B) to be inserted into or removed from the magazine in a state where the embedding blocks held in a cassette (K) to which ID data is attached are arranged vertically in one row; a magazine holding portion (3) which detachably holds each of the magazines; and a reading portion (20) which reads the ID data. The magazine holding portion includes a rotary body (50) which is rotatable around a rotation axis O, a holding mechanism (51) which is multiply provided on a circumferential wall portion (56a) in the rotary body and detachably holds the magazines individually, and a rotation drive portion (52) which positions one of the magazines at a block extraction position (P2) facing the reading portion by rotating the rotary body, and the magazine positioned at the block extraction position and the reading portion are movable relative to each other along the vertical direction.

公开(公告)号：EP3008447A1

公开(公告)日：2016-04-20

申请号：EP14736451.7

申请日：2014-06-12

申请人： Friedrich Miescher Institute for Biomedical Research

发明人： FRIEDRICH, Rainer ,  GENOUD, Christel ,  WANNER, Adrian

IPC分类号： G01N1/00 ,  H01J37/00 ,  G01N1/36 ,  H01J37/20

CPC分类号： G01N1/36 ,  B22F1/0044 ,  B22F1/025 ,  B22F2301/15 ,  B22F2301/255 ,  B22F2304/05 ,  B82Y15/00 ,  G01N2001/364

摘要： The present invention provides a method for preparing a sample for microscopy, said method comprising the steps of contacting said sample with a first polymerizable resin under conditions and for a time sufficient for penetration of said first polymerizable resin into the sample, removing excessive first polymerizable resin from the surface of the sample, contacting the so-prepared sample containing said first polymerizable resin with a second polymerizable resin preparation, said second polymerizable resin preparation comprising a high concentration of electrically conductive particles, and subjecting the so-prepared sample to the curing temperature of the polymerizable resins, wherein the curing temperature of said second polymerizable resin preparation is substantially the same as the curing temperature of the first polymerizable resin.

公开(公告)号：EP2059783A4

公开(公告)日：2016-03-09

申请号：EP07800265

申请日：2007-09-05

申请人： LEICA BIOSYSTEMS MELBOURNE PTY

发明人： WATLING JASON DOUGLAS ,  HAUSLER NICK ,  CONN COSTA

IPC分类号： G01N1/36 ,  G01N1/28

CPC分类号： G01N1/36 ,  G01N1/30

摘要： The present invention relates to a composition and method for handling tissue samples for analysis. In particular the present invention relates to a composition and method for orientating tissue for histological and/or pathological laboratory analysis.

公开(公告)号：EP2811281A4

公开(公告)日：2015-09-23

申请号：EP12867600

申请日：2012-12-06

申请人： NAT CANCER CT

发明人： SONG GANG WON ,  KIM YON HUI ,  KIM IN HOO ,  LEE JIN SOO ,  LEE GUN KOOK

IPC分类号： G01N1/28 ,  C12Q1/00 ,  C12Q1/02 ,  G01N1/30 ,  G01N1/36 ,  G01N33/48 ,  G01N33/50 ,  G02B21/34

CPC分类号： G01N1/30 ,  G01N1/36 ,  G01N33/5005 ,  G01N33/5088

摘要： The present invention relates to a composition for aggregating biological sample used for manufacturing paraffin block for microscopic observation of biological sample, a method for preparing paraffin block using the same, and a method for microscopic observation of biological sample using the paraffin block, and particularly to a composition for aggregating biological sample including the first composite containing at least one water-soluble polymer selected from the group comprising polyvinyl alcohol, polyethylene oxide, polyacrylamide, polyvinylpyrrolidon, polyacrylic acid, polyethyleneimine, polyamines, polyamideamine, and polydiallyl dimethylammonium chloride and distilled water; and the second composite containing at least one organic solvent selected from the group comprising alcohol, xylene, and acetone and at least one medical adhesive selected from the group comprising cyanoacrylate, fibrin glue, protein glue, polyurethane, and sealant containing PEG (polyethylene glycol), a method for preparing paraffin block using the same, and a method for microscopic observation of biological sample using the prepared paraffin block. According to the present invention, because preparing the sample complex is done in a centrifuge tube in preparing paraffin block using extremely small amount of fluid sample tissue or cells, it is possible to minimize loss or damage of sample, reduce background staining, facilitate the preparing process of paraffin block, save time and cost required for preparing paraffin block, and improve the quality of slide obtained from micro-section of the paraffin block.

摘要翻译： 本发明涉及一种组合物用于聚合用于制造石蜡块用于生物样品的显微镜观察，对使用相同的制备石蜡块的方法，以及使用该石蜡块用于生物样品的显微观察的方法，特别涉及生物样品 用于聚合生物样品包含第一复合含有选自包括聚乙烯醇，聚环氧乙烷，聚丙烯酰胺，聚乙烯吡咯烷酮，聚丙烯酸，聚乙烯亚胺，聚胺，聚酰胺胺，和氯化聚二烯丙基二甲基氯化铵和蒸馏水中的至少一种水溶性聚合物的组合物; 和第二复合含有包括醇，二甲苯和丙酮以及从组中选择的至少一个医疗粘合剂包括氰基丙烯酸酯，纤维蛋白胶，蛋白胶，聚氨酯，和密封剂含有选自的组中的至少一种有机溶剂的PEG（聚乙二醇） ，对于使用相同的制备石蜡块的方法，以及使用所制备的石蜡块，用于生物样品的显微镜观察的方法。 。根据本发明，由于制备样品复合物中使用的流体样品的组织或细胞的极少量制备石蜡块离心管完成后，就可以减少损失或样品的损伤，减少背景染色，便于制备 石蜡块的过程中，保存用于制备石蜡块所需时间和成本，并提高滑动从石蜡块的微部分获得的质量。