公开(公告)号：EP1361823B1

公开(公告)日：2004-08-04

申请号：EP02712181.3

申请日：2002-02-21

申请人： University of Lausanne

发明人： WINTERMARK, Max ,  THIRAN, Jean-Philippe, c/o Signal Processing Lab. ,  MEULI, Reto Antonie

IPC分类号： A61B6/00 ,  A61B5/0275

CPC分类号： A61B5/0275 ,  A61B5/4064 ,  A61B5/4076 ,  A61B5/412 ,  A61B6/00 ,  A61B6/481 ,  A61B6/504 ,  A61B6/507

公开(公告)号：EP1264573A3

公开(公告)日：2004-01-21

申请号：EP02012513.4

申请日：2002-06-04

申请人： Colin Corporation

发明人： Ogura, Toshihiko

IPC分类号： A61B5/022 ,  A61B5/0275

CPC分类号： A61B5/0225 ,  A61B5/02028 ,  A61B5/02225 ,  A61B5/0456 ,  A61B5/6843 ,  A61B2562/0247 ,  A61B2562/043

摘要： An apparatus (10) for blood pressure measurement capable of heart function assessment for readily putting on a living subject, comprising an inflatable cuff including a pressure-pulse-wave sensor (28), which is combined with the cuff at an upper-stream side end of the cuff, when wrapped around an upper-arm portion (14), so as to detect, at the upper-stream side than a blood-flow stopped position, the pressure-pulse-wave, which is of the same waveform as an aorta waveform, while blood-flow is stopped, and an ejection time calculating means (a heart function parameter calculating means) (100), by which an ejection time ET can be calculated as a time difference from a rising-point to a dicrotic notch of the pressure-pulse waveform for heart function assessment. Since a blood pressure BP also can be measured with the cuff (12), all the putting on the living subject, that is needed to measure the blood pressure and heart-function is to put on the cuff (12), which is combined with the pressure-pulse wave sensor (28), and to wrap the cuff around the upper-arm portion (14), therefore, putting-on becomes more simple and easier for measuring a heart function parameter and a blood pressure.

公开(公告)号：EP1361823A1

公开(公告)日：2003-11-19

申请号：EP02712181.3

申请日：2002-02-21

申请人： University of Lausanne

发明人： WINTERMARK, Max ,  THIRAN, Jean-Philippe,c/o Signal Processing Lab. ,  RETO, Antoine Meuli

IPC分类号： A61B6/00 ,  A61B5/0275

CPC分类号： A61B5/0275 ,  A61B5/4064 ,  A61B5/4076 ,  A61B5/412 ,  A61B6/00 ,  A61B6/481 ,  A61B6/504 ,  A61B6/507

摘要： A method and apparatus for evaluating acute stroke patients and for determining whether a stroke patient will benefit from the use of thrombolysis therapy includes obtaining measurements of the cerebral blood flow and cerebral blood volume of the brain of a stroke patient, determining ischemic areas of the brain where the ischemic areas comprise the measurements of cerebral blood flow which are less than a first value and creating a penumbra-infarct map of the ischemic areas of the brain using the measurements. The infarct area corresponds to the area of the brain where cerebral blood volume is less than a second value. The penumbra area corresponds to the area of the brain where cerebral blood volume is greater than this second dvalue. The method also includes determining a ratio of penumbra size to the total of penumbra size and infarct size. When the ratio is greater than a predetermined value, the stroke patient is a candidate for thrombolysis therapy.

公开(公告)号：EP1345638A1

公开(公告)日：2003-09-24

申请号：EP01991153.6

申请日：2001-12-20

申请人： Hema Metrics, Inc.

发明人： STEUER, Robert, R. ,  BELL, David, A ,  MILLER, David, R

IPC分类号： A61M1/36 ,  A61B5/0275

CPC分类号： A61B5/0275 ,  A61M1/3609 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3656

摘要： Indicator dilution techniques are used to measure vascular access flow rates during routine hemodialysis. A bolus injection port is used to infuse a specific volume (Vi) of an indicator diluent, such as saline or dye, into the patient cardiovascular circuit by one of the following: 1. Needle injection of a known volume (bolus) of indicator diluent directly into the access site in the presence or absence of the hemodialysis circuit. 2. Infusion of an indicator diluent into the arterial, venous line upstream of the venous needle. 3. Turning the ultrafiltration of the dialysis delivery system from OFF to ON and OFF again over a predetermined time period. 4. In a hemodialysis circuit, turning on the hemodialysis pump and using the priming saline volume as a single saline bolus. A transdermal sensor (10) is used to measure the percent change in a blood parameter. The sensor (10) is positioned directly over the vascular access site (12) a prescribed distance downstream of the injection site (12) and upstream of the access-vein connection (20C). The sensor (109) employs emitter (10A) and detector (106) elements at multiple spacings (d1, d2) for the purpose of measuring the bulk absorptivity (a) of the area immediately surrounding and including the access site (12), and the absorptivity (a) of the tissue itself.

公开(公告)号：EP1220691A4

公开(公告)日：2003-07-16

申请号：EP00968477

申请日：2000-09-27

申请人： UNIV LELAND STANFORD JUNIOR

发明人： STRAUSS H WILLIAM

IPC分类号： A61B19/00 ,  A61B5/0275 ,  A61B6/00 ,  A61K51/00 ,  A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  A61K49/00 ,  A61K49/04 ,  G01T1/161

CPC分类号： A61K51/0491 ,  A61B5/02755 ,  A61B6/4258 ,  A61B6/504 ,  A61K51/1018

摘要： Methods, devices, and kits, for assessing luminal lesions are provided. The subject devices comprise an intraluminal detector capable of sensing radioactive or other labels. In the subject methods, a detectable marker is introduced to a body lumen, either into the lumen itself or systemically in patient circulation, and localizes at a lesion. The detector is introduced into the body lumen and the distribution of a localized marker detected in situ. The information is useful for a number of purposes including the identification of unstable plaque in patients suffering from atherosclerotic disease.

公开(公告)号：EP1315448A1

公开(公告)日：2003-06-04

申请号：EP01975007.4

申请日：2001-08-30

申请人： Jansen, Jozef Reinier Cornelis ,  Schreuder, Johannes Jacobus

发明人： JANSEN, Jozef, Reinier, Cornelis ,  SCHREUDER, Johannes, Jacobus ,  KORNET, Lilian

IPC分类号： A61B5/0275 ,  A61B5/05

CPC分类号： A61B5/0275 ,  A61B5/0295 ,  A61B5/0535

摘要： The segment volume of a cardiac chamber or blood vessel of a patient is determined by injecting a first indicator in the blood stream of a patient, which influences the conductance of the blood. The electrical conductance in the cardiac chamber or blood vessel is measured. An injected quantity of indicator is determined and the development of the concentration of this indicator in the blood is measured wherein the cardiac output is calculated from the injected quantity of indicator and the development of the concentration in the blood. Subsequently, the segment volume and electrical parallel conductance of a cardiac chamber or blood vessel are calculated from the calculated cardiac output, the injected quantity of conductance indicator and the measured conductance.

公开(公告)号：EP1022984A1

公开(公告)日：2000-08-02

申请号：EP99942720.6

申请日：1999-07-01

申请人： Hoeft, Andreas, Dr. med.

发明人： Hoeft, Andreas, Dr. med.

IPC分类号： A61B5/0275 ,  A61B5/00 ,  A61B5/026

CPC分类号： A61B5/0275 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/4244

摘要： The liver function is determined after an indicator dye has been injected into the blood circulation system, the resulting concentration of the indicator dye in the blood has been measured by optical means and the rate at which plasma disappears has been calculated based on the dye concentration in relation to the time elapsed. An average circulation transit time mttcirc is determined based on the measurement of the concentration of dye c(t). A parameter k which represents a fractional re-entry rate of the indicator dye after each circulatory passage is established. The rate at which the plasma disappears PDR is obtained according to the formula PDR = (1-k)/(k.mttcirc).

公开(公告)号：EP1011430A1

公开(公告)日：2000-06-28

申请号：EP97917730.0

申请日：1997-03-31

申请人： MERCK & CO., INC.

发明人： SHEN, You-Tang

IPC分类号： A61B5/02 ,  A61B5/0215 ,  A61B5/022 ,  A61B5/026 ,  A61B5/0275

CPC分类号： A61B5/02 ,  A61B5/0215 ,  A61B5/026

摘要： A method of simulating congestive heart failure uses catheters (aortic, right atrial, and left atrial), hydraulic occluders (#1, #2), and pacemaker probes (RV, LA) attached to an animal's heart (not numbered) to simulate a chronic condition. A pressure gauge (LV) and flow probe sensor (aortic) are also attached to the heart to monitor the effects of a test compound on the animal's cardiac function and systemic vascular dynamics. A method for assessing the effects of this test compound is included.

公开(公告)号：EP0461503A1

公开(公告)日：1991-12-18

申请号：EP91108992.8

申请日：1991-06-01

申请人： TRITON TECHNOLOGY, INC.

发明人： Heusch, Gerd, Dr. ,  Gross, Rainer, Dr. ,  Paffhausen, Wolfgang, Dr. ,  Schade, Andreas

IPC分类号： A61B5/0275

CPC分类号： A61K51/1255 ,  A61B5/0275 ,  A61K2123/00 ,  Y10T436/13

摘要： Es wird ein verbessertes Verfahren zur Durchblutungsmessung mittels gefärbter Mikrokugeln vorgestellt, das bisherige Auszählverfahren bei der Anwendung gefärbter Mikrokugeln durch eine schnell reproduzierbare Meßmethode ersetzt. Die aufwendige und teure Verwendung radioaktiv markierter Mikrokugeln wird dadurch vermieden. Gleichzeitig wird ein Färbeverfahren zur Präparation der Mikrokugeln vorgestellt, das sich durch eine homogene und intensive Färbung der Mikrokugeln auszeichnet.

摘要翻译： 提出了一种通过有色微球测量血流量的改进方法，其替代了使用有色微球体的以前的计数方法，其具有快速重现的测量方法。 以这种方式避免了精心制作和昂贵使用放射性标记的微球。 同时，提出了制备微球的着色方法，该方法的特征在于微球的均匀且强烈的着色。 ... ...

公开(公告)号：EP0370637A1

公开(公告)日：1990-05-30

申请号：EP89311186.4

申请日：1989-10-30

申请人： PICKER INTERNATIONAL, INC.

发明人： Lindstrom, Walter W.

IPC分类号： A61B5/0275 ,  A61B5/08 ,  A61B6/00

CPC分类号： A61B6/032 ,  A61B5/0275 ,  A61B5/0813 ,  A61B6/481 ,  A61B6/507 ,  G06T5/50

摘要： In the method and apparatus, a patient breathing through a mask (34) receives breathing air from a breathing air system (A). A xenon gas supply (12) selectively supplies xenon or other enhancement gases into the breathing air. During each exhalation portion of a respiratory cycle, a portion of the exhaled gas passes through a narrow tube (40) to a xenon concentration detector (44) and a carbon dioxide concentration detector (46). A carbon dioxide concentration comparing circuit (54) compares the carbon dioxide concentration values with characteristics (56) of carbon dioxide concentration during a end-tidal portion of the exhalation respiratory cycle. Xenon concentrations read during the end-tidal portion of the respiratory cycle (62) are utilized to project a blood absorption curve (64).
In the application of the method and apparatus in a medical diagnostic imaging system including a computed tomography (CT) scanner, a plurality of CT images are generated by the CT scanner (B) as the blood xenon concentration increases. A look-up table array (90) preprogrammed in accordance with the Kety equations is addressed by the blood xenon concentration curve and the pixel values of the CT images to generate partition coefficient and flow values.

摘要翻译： 在该方法和装置，通过掩模的患者呼吸（34）接收从一个呼吸空气系统（A）的呼吸空气。 氙气体的供给（12）选择性地供应氙或其他增强气体进入呼吸空气。 在呼吸循环的呼气各部分，所述呼出气体的一部分穿过细管（40），氙浓度检测器（44）和二氧化碳浓度检测器（46）。 二氧化碳浓度比较电路（54）的呼出呼吸循环的呼气末部分期间与二氧化碳浓度的特性（56）比较二氧化碳浓度的值。 氙浓度呼吸周期（62）的末部分期间读取被用于投射血液吸收曲线（64）。 在医学诊断成像系统，包括由CT扫描仪（B）作为血液氙浓度的增加，产生CT图像生成多个计算机断层摄影（CT）扫描仪的方法和装置的应用。 在雅舞蹈预编程了凯蒂方程的查找表阵列（90）是由血液氙浓度曲线寻址和CT图像的像素值，以产生分配系数和流量值。