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367 条记录 (耗时 0.028 秒)

    HETEROCYCLE-FUSED MORPHINANS, USE THEREOF AND PREPARATION THEREOF
    21.
    发明公开
    HETEROCYCLE-FUSED MORPHINANS, USE THEREOF AND PREPARATION THEREOF 审中-公开
    赫尔辛基多瑙河

    公开(公告)号：EP2844661A4

    公开(公告)日：2015-11-11

    申请号：EP13784443

    申请日：2013-05-02

    申请人： SOUTHERN RES INST

    发明人： ANANTHAN SUBRAMANIAM

    IPC分类号： C07D489/08 ,  A61K31/485 ,  A61P37/00

    CPC分类号： C07D491/18 ,  C07D489/02 ,  C07D489/06 ,  C07D489/08

    摘要： Provided are compounds of the formula: R1; R2, R3; R4; A; X; Y and Z are defined in the present disclosure; pharmaceutically acceptable salts thereof, deuterium forms thereof, isomers thereof, and mixture thereof; and processes for their preparation. The compounds can be used for treating a patient suffering from a condition that is capable of treatment with an agonist and/or antagonist of the opioid receptors and are especially useful a patient suffering from pain, treating a patient in need of an immunosuppressant to prevent rejection in organ transplant and skin graft, in need of an anti-allergic agent, in need of an anti-inflammatory agent, in need of a brain cell protectant, for drug and/or alcohol abuse, to decrease gastric secretion, for diarrhea, for cardiovascular disease, for a respiratory disease, in need of a cough and/or respiratory depressant, for mental illness, for epileptic seizures and other neurologic disorders.

    摘要翻译： 提供下式的化合物：R1; R2，R3; R4; 一个; X; Y和Z在本公开中定义; 其药学上可接受的盐，其氘形式，其异构体及其混合物; 及其制备方法。 该化合物可用于治疗患有可用阿片样物质受体的激动剂和/或拮抗剂治疗的病症的患者，并且对患有疼痛的患者特别有用，治疗需要免疫抑制剂的患者以防止排斥 在器官移植和皮肤移植中，需要抗过敏剂，需要抗炎剂，需要脑细胞保护剂，用于药物和/或酒精滥用，以减少胃分泌，腹泻，腹泻 心血管疾病，呼吸道疾病，需要咳嗽和/或呼吸抑制剂，精神疾病，癫痫发作和其他神经系统疾病。

    PROCESS FOR RECOVERY OF NALMEFENE HYDROCHLORIDE
    25.
    发明公开
    PROCESS FOR RECOVERY OF NALMEFENE HYDROCHLORIDE 有权
    回收盐酸纳美芬的方法

    公开(公告)号：EP2788357A1

    公开(公告)日：2014-10-15

    申请号：EP12797909.4

    申请日：2012-12-06

    申请人： H. Lundbeck A/S

    发明人： DE FAVERI, Carla ,  STIVANELLO, Mariano

    IPC分类号： C07D489/08 ,  A61K31/485 ,  A61P25/30

    CPC分类号： C07D489/08 ,  A61K31/485

    摘要： The present invention relates to an improved process for recovery of nalmefene hydrochloride [17-(cyclopropylmethyl)-4,5-alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride] from an aqueous composition containing nalmefene and certain impurities.

    摘要翻译： 本发明涉及从含有纳美芬和某些杂质的含水组合物中回收盐酸纳美芬[17-（环丙基甲基）-4,5-α-环氧-6-亚甲基吗啡喃-3,14-二醇盐酸盐]的改进方法。