公开(公告)号：EP3601292B1

公开(公告)日：2024-09-11

申请号：EP18718883.4

申请日：2018-03-27

IPC: C07D491/18 ,  C08F265/06 ,  C08F222/00 ,  C08L33/12

CPC classification number: C07D491/18 ,  C08F265/06

公开(公告)号：EP3294418A1

公开(公告)日：2018-03-21

申请号：EP16793249

申请日：2016-05-06

Applicant: HARVARD COLLEGE

Inventor： SHAIR MATTHEW D ,  PELISH HENRY EFREM ,  NITULESCU IOANA LLINCA

IPC: A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07D493/08 ,  C07D493/22

CPC classification number: C07D493/08 ,  C07D491/18 ,  C07D519/00

Abstract: A method for the targeted selection and treatment of patients with a tumor or cancer, comprising (i) determining whether the patient has a RUNX1 pathway impairment; and if so (ii) administering an effective amount of a cortistatin or its pharmaceutically acceptable salt or oxide, optionally in a pharmaceutically acceptable composition.

公开(公告)号：EP3201196A1

公开(公告)日：2017-08-09

申请号：EP15771976.6

申请日：2015-10-02

Applicant: UCB Biopharma SPRL ,  SANOFI

Inventor： DE HARO GARCIA, Teresa ,  DELIGNY, Michael ,  HEER, Jag Paul ,  QUINCEY, Joanna Rachel ,  XUAN, Mengyang ,  ZHU, Zhaoning ,  BROOKINGS, Daniel Christopher ,  CALMIANO, Mark Daniel ,  EVRARD, Yves ,  HUTCHINGS, Martin Clive ,  JOHNSON, James Andrew ,  JADOT, Sophie ,  KEYAERTS, Jean ,  MAC COSS, Malcolm ,  SELBY, Matthew Duncan ,  SHAW, Michael Alan ,  SWINNEN, Dominique Louis Léon ,  SCHIO, Laurent ,  FORICHER, Yann ,  FILOCHE-ROMME, Bruno

IPC: C07D471/18 ,  C07D487/18 ,  C07D493/18 ,  A61K31/4188 ,  A61P3/00 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D519/00 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/55 ,  C07D471/18 ,  C07D487/08 ,  C07D487/18 ,  C07D491/08 ,  C07D491/18 ,  C07D493/18 ,  C07D495/08 ,  C07D495/18 ,  C07D513/18 ,  C07F7/1852

Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Abstract translation: 一系列稠合的五环咪唑衍生物是人TNFα活性的有效调节剂，因此在治疗和/或预防各种人类疾病中是有益的，所述人类疾病包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疼痛; 心血管疾病; 代谢紊乱; 眼病; 和肿瘤疾病。 特别地，本发明涉及6,7-二氢-7,14-亚甲基苯并咪唑并[1,2-b] [2,5]苯并二氮杂-5（14H） - 酮衍生物及其类似物。

公开(公告)号：EP2978429B1

公开(公告)日：2017-02-22

申请号：EP14717689.5

申请日：2014-03-28

Applicant: Janssen Sciences Ireland UC

Inventor： BONFANTI, Jean-François ,  FORTIN, Jérôme Michel Claude ,  MULLER, Philippe ,  DOUBLET, Frédéric Marc Maurice ,  RABOISSON, Pierre Jean-Marie Bernard ,  ARNOULT, Eric Pierre Alexandre

IPC: C07D471/18 ,  C07D498/22 ,  C07D498/18

CPC classification number: C07D491/18 ,  C07D471/18 ,  C07D491/22 ,  C07D498/18 ,  C07D498/22

公开(公告)号：EP2822953B1

公开(公告)日：2017-02-01

申请号：EP13717555.0

申请日：2013-02-20

Applicant: Pfizer Inc.

Inventor： BAILEY, Simon ,  BURKE, Benjamin, Joseph ,  COLLINS, Michael, Raymond ,  CUI, Jingrong, Jean ,  DEAL, Judith, Gail ,  HOFFMAN, Robert, Louis ,  HUANG, Qinhua ,  JOHNSON, Ted, William ,  KANIA, Robert, Steven ,  KATH, John, Charles ,  LE, Phuong, Thi, Quy ,  MCTIGUE, Michele, Ann ,  PALMER, Cynthia, Louise ,  RICHARDSON, Paul, Francis ,  SACH, Neal, William

IPC: C07D491/08 ,  C07D491/18 ,  C07D498/08 ,  C07D498/18 ,  C07D498/22 ,  C07D513/18 ,  A61K31/4353 ,  A61P35/00

CPC classification number: C07D498/08 ,  C07D273/02 ,  C07D413/04 ,  C07D413/14 ,  C07D491/08 ,  C07D491/18 ,  C07D498/18 ,  C07D498/22 ,  C07D513/18

公开(公告)号：EP1944292B1

公开(公告)日：2016-02-17

申请号：EP08004779.8

申请日：2001-10-31

Applicant: RENSSELAER POLYTECHNIC INSTITUTE

Inventor： Wentland, Mark P.

IPC: C07D221/26 ,  A61K31/485 ,  A61P25/04 ,  A61P25/36 ,  C07D405/06 ,  C07D489/00 ,  C07D489/08 ,  C07D491/20 ,  C07D491/22 ,  C07D489/10 ,  C07D401/04

CPC classification number: C07D489/12 ,  A61K31/485 ,  C07D221/22 ,  C07D221/26 ,  C07D401/04 ,  C07D405/06 ,  C07D489/00 ,  C07D489/02 ,  C07D489/08 ,  C07D489/10 ,  C07D491/18

Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is -CH2-OH, -CH2NH2, -NHSO2CH3, and Y is O, S, NR or NOH bind to opioid receptors and are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.

公开(公告)号：EP2313370B1

公开(公告)日：2015-08-19

申请号：EP09772473.6

申请日：2009-07-01

Applicant: Syngenta Limited

Inventor： JEANMART, Stephane, André, Marie ,  VINER, Russell ,  TAYLOR, John, Benjamin ,  WHITTINGHAM, William, Guy ,  WAILES, Jeffrey, Steven ,  TARGETT, Sarah ,  MATHEWS, Christopher, John ,  GOVENKAR, Mangala ,  CORDINGLEY, Matthew, Robert ,  RUSSELL, Claire, Janet ,  TYTE, Melloney

IPC: C07D207/08 ,  C07D207/48 ,  C07D211/32 ,  C07D211/94 ,  C07D211/96 ,  C07D307/12 ,  C07D309/04 ,  C07D307/26 ,  C07D309/12 ,  C07D335/02 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D491/18

CPC classification number: C07D309/04 ,  A01N43/08 ,  A01N43/10 ,  A01N43/16 ,  A01N43/18 ,  A01N43/20 ,  A01N43/28 ,  A01N43/32 ,  A01N43/36 ,  A01N43/40 ,  A01N43/56 ,  A01N43/80 ,  A01N43/84 ,  A01N43/90 ,  A01N47/00 ,  A01N47/06 ,  A01N47/16 ,  A01N47/38 ,  A01N53/00 ,  A01N55/00 ,  C07D207/08 ,  C07D207/48 ,  C07D211/32 ,  C07D211/94 ,  C07D211/96 ,  C07D307/12 ,  C07D317/26 ,  C07D319/12 ,  C07D335/02 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D491/18 ,  C07F7/0812

公开(公告)号：EP2767538A4

公开(公告)日：2015-05-06

申请号：EP12825975

申请日：2012-08-20

Applicant: HANGZHOU BENSHENG PHARMACEUTICAL CO LTD

Inventor： XU RONGZHEN ,  RONG FRANK ,  XIE FUWEN ,  LAI HONGXI

IPC: C07D491/147 ,  A61K31/4748 ,  A61P35/00 ,  C07D491/18 ,  C07D491/22

CPC classification number: C07D491/22 ,  C07D491/147 ,  C07D491/18

公开(公告)号：EP2844661A1

公开(公告)日：2015-03-11

申请号：EP13784443.7

申请日：2013-05-02

Applicant: Southern Research Institute

Inventor： ANANTHAN, Subramaniam

IPC: C07D489/08

CPC classification number: C07D491/18 ,  C07D489/02 ,  C07D489/06 ,  C07D489/08

Abstract: The present disclosure is concerned with a process for the preparation of the above disclosed compounds, pharmaceutically acceptable salts thereof, deuterated forms thereof, isomers thereof, solvates thereof, or mixtures thereof which comprises subjecting a 17-substituted-3, 14-dihydroxypyridomorphinan to dialkylation at the phenolic hydroxyl at the 3-position and the tertiary alcohol at the 14-position followed by selective dealkylation of the phenolic ether function.

公开(公告)号：EP2377845B1

公开(公告)日：2015-01-28

申请号：EP09832948.5

申请日：2009-12-18

Applicant: East China University of Science and Technology ,  Shanghai Shengnong Pesticide Co., Ltd.

Inventor： LI, Zhong ,  QIAN, Xuhong ,  SHAO, Xusheng ,  XU, Xiaoyong ,  TAO, Liming ,  SONG, Gonghua

IPC: C07D401/14 ,  C07D213/61 ,  C07D417/14 ,  C07D498/08 ,  C07D498/18 ,  C07D405/14 ,  A01N43/50 ,  A01N43/40 ,  A01N43/78 ,  A01N43/54 ,  A01N43/90 ,  A01P7/00

CPC classification number: A01N43/90 ,  A01N43/40 ,  A01N43/50 ,  A01N43/54 ,  A01N43/62 ,  A01N43/78 ,  C07D213/61 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D471/14 ,  C07D491/18 ,  C07D498/08 ,  C07D498/18