公开(公告)号：EP4444721A1

公开(公告)日：2024-10-16

申请号：EP22847033.2

申请日：2022-12-09

申请人： Prothena Biosciences Limited

发明人： DE LOMBAERT, Stéphane

IPC分类号： C07D487/04 ,  A61P25/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/04 ,  C07D491/16

公开(公告)号：EP3733187B1

公开(公告)日：2024-10-16

申请号：EP20181616.2

申请日：2016-07-20

发明人： CUI, Jingrong Jean ,  LI, Yishan ,  ROGERS, Evan W. ,  ZHAI, Dayong ,  DENG, Wei ,  HUANG, Zhongdong

IPC分类号： A61K31/519 ,  A61K31/52 ,  C07D491/16 ,  C07D491/12 ,  C07D491/18 ,  C07D498/18 ,  A61P35/00

公开(公告)号：EP3551632B1

公开(公告)日：2024-06-12

申请号：EP17811328.8

申请日：2017-12-12

IPC分类号： C07D491/14 ,  C07D491/16 ,  A61P17/00 ,  A61K31/55

CPC分类号： C07D491/14 ,  C07D491/16 ,  A61P17/00

公开(公告)号：EP4263544A1

公开(公告)日：2023-10-25

申请号：EP21820651.4

申请日：2021-12-15

申请人： Merck Patent GmbH

发明人： STOESSEL, Philipp

IPC分类号： C07D487/06 ,  C07D487/22 ,  C07D471/16 ,  C07D491/16 ,  C07D491/22 ,  C07D498/22 ,  C07F7/02 ,  C07F7/10 ,  C07F15/00 ,  C09K11/06 ,  H01J1/63 ,  H01J29/08 ,  H01L29/08 ,  H01J35/24 ,  H01L51/00 ,  H01L51/50 ,  H01L51/56

公开(公告)号：EP4263543A1

公开(公告)日：2023-10-25

申请号：EP21823946.5

申请日：2021-12-15

申请人： Merck Patent GmbH

发明人： STOESSEL, Philipp

IPC分类号： C07D471/16 ,  C07D487/04 ,  C07D487/16 ,  C07D487/22 ,  C07D491/16 ,  C07D491/22 ,  H01L51/00

公开(公告)号：EP4194456A1

公开(公告)日：2023-06-14

申请号：EP21213131.2

申请日：2021-12-08

申请人： Julius-Maximilians-Universität Würzburg

发明人： Dandekar, Thomas ,  Sarukhanyan, Edita

IPC分类号： C07D471/06 ,  A61P25/28 ,  C07D311/92 ,  C07D471/16 ,  C07D491/16 ,  C07D493/16 ,  C07F9/48 ,  C07F9/6571

摘要： The present invention relates to a new compound according to formula (I) as well as to the use of this compound in medicine, in the prevention of the aggregation of phosphorylated Tau proteins, the treatment or prevention of a tauopathy and in the treatment or prevention of a neurodegenerative disease, preferably selected from the group consisting of Primary age-related tauopathy (PART) dementia, Chronic traumatic encephalopathy, Progressive supranuclear palsy, Corticobasal degeneration and Alzheimer's disease, more preferably Alzheimer's disease.

公开(公告)号：EP3551632A1

公开(公告)日：2019-10-16

申请号：EP17811328.8

申请日：2017-12-12

申请人： Leo Pharma A/S

发明人： LIANG, Xifu ,  LARSEN, Jens ,  NIELSEN, Simon Feldbæk ,  ANDERSEN, Peter

IPC分类号： C07D491/14 ,  C07D491/16 ,  A61P17/00 ,  A61K31/55

公开(公告)号：EP2782916B1

公开(公告)日：2018-02-28

申请号：EP12798535.6

申请日：2012-11-20

申请人： Promega Corporation

发明人： KIRKLAND, Thomas, A. ,  MCDOUGALL, Mark, G. ,  DWIGHT, Stephen

IPC分类号： C07D491/16 ,  C07D491/22 ,  C07D491/147 ,  C07D223/16 ,  C07F9/6558 ,  C09B11/24 ,  C12Q1/68 ,  G01N33/50

CPC分类号： G01N33/542 ,  C07D223/16 ,  C07D471/06 ,  C07D491/147 ,  C07D491/16 ,  C07D491/22 ,  C07F9/65586 ,  C07H19/073 ,  C07H19/10 ,  C09B11/24 ,  C12Q1/686 ,  G01N33/582 ,  G01N33/6845 ,  G01N2333/90241

摘要： The present invention provides novel fluorescent dyes and kits containing the same, which are useful for labeling a wide variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis and/or treatment of disease conditions.

公开(公告)号：EP2109615A1

公开(公告)日：2009-10-21

申请号：EP08713287.4

申请日：2008-01-25

申请人： Merck & Co., Inc.

发明人： DEBENHAM, John, S. ,  HALE, Jeffrey, J. ,  HUO, Pei ,  MADSEN-DUGGAN, Christina, B. ,  WALSH, Thomas, F. ,  YAN, Lin

IPC分类号： C07D491/052 ,  C07D491/16 ,  C07D495/16 ,  A61K31/436 ,  A61P1/00 ,  A61P25/00

CPC分类号： C07D491/052 ,  C07D491/16 ,  C07D495/16

摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, Huntington's disease movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.

公开(公告)号：EP1486549A4

公开(公告)日：2007-04-18

申请号：EP02724636

申请日：2002-04-23

申请人： HAYASHIBARA BIOCHEM LAB ,  TOYOTA JIDOSHOKKI KK

发明人： SATSUKI MAKOTO ,  ISHIDA NATSUKO ,  SUGA SADAHARU ,  FUJIKAWA HISAYOSHI ,  TAGA YASUNORI ,  NAKAGAWA SATOSHI ,  MURASAKI TAKANORI ,  KATO YOSHIFUMI

IPC分类号： H01L51/50 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D491/16 ,  C09K11/06 ,  H01L51/00 ,  H01L51/30 ,  H05B33/14

CPC分类号： H01L51/0073 ,  C09K11/06 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/1044 ,  C09K2211/1074 ,  C09K2211/1088 ,  C09K2211/188 ,  H01L51/005 ,  H01L51/0059 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0078 ,  H01L51/0081 ,  H01L51/5012 ,  H01L2251/308 ,  H05B33/14 ,  Y10S428/917

摘要： A light emitting agent for an organic electroluminescent element favorable in the organic electroluminescent element of high durability, and applications thereof, and more specifically, an auxiliary light emitting agent for the organic electroluminescent element consisting of a specified coumarin derivative, the organic electroluminescent element using the auxiliary light emitting agent, and a display panel and an information display appliance using the organic electroluminescent element.