公开(公告)号：EP4435100A2

公开(公告)日：2024-09-25

申请号：EP24188375.0

申请日：2011-10-03

申请人： ModernaTX, Inc.

发明人： Schrum, Jason P. ,  Siddiqi, Suhaib ,  Ejebe, Kenechi

IPC分类号： C12N15/09

CPC分类号： C07H21/02 ,  C07H19/10 ,  C12N15/102

摘要： The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using thereof.

公开(公告)号：EP4392431A1

公开(公告)日：2024-07-03

申请号：EP22793641.6

申请日：2022-09-29

申请人： Pyrotech (Beijing) Biotechnology Co., Ltd.

发明人： DU, Nana ,  O'YANG, Counde ,  WANG, Hexiang ,  LI, Zhihong

IPC分类号： C07H19/10 ,  C07H19/207 ,  A61K31/7052 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07H19/10 ,  C07H19/207 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07H13/02

公开(公告)号：EP4303314A3

公开(公告)日：2024-04-17

申请号：EP23186456.2

申请日：2016-08-26

申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

发明人： BERGMANN, Frank ,  SEIDEL, Christoph ,  TRANS, Andrew ,  GREMYACHINSKIY, Dimitry ,  KUCHELMEISTER, Hannes ,  HILLRINGHAUS, Lars

IPC分类号： C12Q1/6869 ,  C07H19/10 ,  C07H19/20

CPC分类号： C07H19/10 ,  C07H19/20 ,  C12Q1/6869

摘要： The present disclosure relates to compositions and methods based on polypeptide-tagged nucleotide, and the use of such polypeptide-tagged nucleotides in nanopore devices and methods.

公开(公告)号：EP2998307B1

公开(公告)日：2018-10-31

申请号：EP14798157.5

申请日：2014-03-20

申请人： Beijing SL Pharmaceutical Co., Ltd.

发明人： WANG, Jianming ,  CHEN, Xiaoguang ,  CHEN, Junping ,  FAN, Shan

IPC分类号： C07F9/40 ,  C07H19/10 ,  C07H19/207 ,  A61K31/661 ,  A61P31/14

CPC分类号： C07F9/65616 ,  C07F9/3808 ,  C07F9/4065 ,  C07F9/4087 ,  C07F9/6524 ,  C07F9/65517 ,  C07F9/65586 ,  C07F9/6561 ,  C07F9/657181 ,  C07F9/65742 ,  C07H19/10 ,  C07H19/207

摘要： The present invention relates to phosphoric acid/phosphonic acid derivatives shown by formula (I), wherein, R 1 or R 2 represents the following structures: (Q1), or (Q2), or (Q3). Q1 represents ester derivatives of L-amino acid, wherein R 3 is alkyl with 1-6 carbon atoms or cycloalkyl, R 4 is H or alkyl with 1-6 carbon atoms; Q2 represents hydroxyl substituted benzodioxane derivatives; Q3 represents hydroxyl substituted benzodioxolane derivatives; R 1 or R 2 is the same or different, but at least one of them is Q2 or Q3; D represents residues of pharmacologically active molecules containing a phosphate/phosphonate group, i.e. formula (II) represents pharmacologically active molecules containing a phosphate/phosphonate group; and when R 1 and R 2 are different, the configuration of the P atom connected to R 1 and R 2 is of R or S type.

公开(公告)号：EP3172216B1

公开(公告)日：2018-10-10

申请号：EP14772458.7

申请日：2014-08-22

申请人： Adam Mickiewicz University

发明人： CELEWICZ, Lech ,  KACPRZAK, Karol ,  LEWANDOWSKA, Marta ,  RUSZKOWSKI, Piotr

IPC分类号： C07F9/24 ,  C07H19/073 ,  A61K33/42 ,  A61P35/00

CPC分类号： C07H19/10 ,  A61K33/42 ,  C07F9/24 ,  C07F9/6561 ,  C07H19/073

摘要： The subject matter of the invention is novel 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.

公开(公告)号：EP3378869A1

公开(公告)日：2018-09-26

申请号：EP16866398.7

申请日：2016-11-17

申请人： Nissan Chemical Corporation

发明人： SUGAWARA, Yudai

IPC分类号： C07H21/04 ,  C07H19/10 ,  C07H19/20

CPC分类号： C07H19/10 ,  C07H19/20 ,  C07H21/04 ,  Y02P20/55

摘要： The invention provides a novel method for producing an oligonucleotide using a nucleoside or oligonucleotide that is easy to isolate and has high storage stability. The oligonucleotide production method includes a step of subjecting a nucleoside or oligonucleotide having a pseudo solid phase-protecting group in at least one location selected from the group consisting of 2'-position, 3'-position, 5'-position and a nucleobase moiety and having a 5'-hydroxyl group or a 3'-hydroxyl group, to H-phosphonation to convert the 5'-hydroxyl group or the 3'-hydroxyl group into an H-phosphonated form.

公开(公告)号：EP2619215B1

公开(公告)日：2018-09-05

申请号：EP11827315.0

申请日：2011-09-19

申请人： Alios Biopharma, Inc.

发明人： BEIGELMAN, Leonid ,  DEVAL, Jerome ,  SMITH, David, Bernard ,  WANG, Guangyi ,  RAJWANSHI, Vivek, Kumar

IPC分类号： A61K31/708 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  C07H19/04 ,  C07H19/06 ,  C07H19/056 ,  A61P31/12

CPC分类号： C07H19/06 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  A61K45/06 ,  C07H19/056 ,  C07H19/067 ,  C07H19/073 ,  C07H19/09 ,  C07H19/10 ,  C07H19/11 ,  C07H19/16 ,  C07H19/167 ,  C07H19/19 ,  C07H19/20 ,  A61K2300/00

摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

公开(公告)号：EP1928475B1

公开(公告)日：2018-05-23

申请号：EP06778153.4

申请日：2006-08-03

申请人： Riboscience LLC

发明人： KLUMPP, Klaus ,  MARTIN, Joseph Armstrong ,  MCGUIGAN, Christopher ,  SMITH, David Bernard

IPC分类号： A61K31/7064 ,  A61K31/7076 ,  C07H19/10

CPC分类号： C07H19/10 ,  C07H19/04

摘要： The invention provides novel nucleoside compounds of formula I wherein R1, R2a, R2b, R3, R4, R5 R6, R8a, R9 and R10 are as defined herein which are useful for the treatment of Hepatitis C Virus (HCV) mediated diseases. The invention further provides methods for treatment or prophylaxis of HCV mediated diseases with compounds of formula I and pharmaceutical compositions comprising these compounds,

公开(公告)号：EP3303359A1

公开(公告)日：2018-04-11

申请号：EP16724066.2

申请日：2016-05-23

申请人： Idenix Pharmaceuticals LLC

发明人： DOUSSON, Cyril, B. ,  DUKHAN, David ,  PARSY, Christophe Claude

IPC分类号： C07H19/10 ,  C07H19/11 ,  A61K31/7068 ,  A61P35/00

CPC分类号： C07H19/11 ,  A61P35/00 ,  C07H19/10

摘要： The present invention relates to novel nucleoside derivatives, pharmaceutical compositions comprising the compounds, processes of preparation thereof, and methods of use thereof for treating cancer.

公开(公告)号：EP3298023A1

公开(公告)日：2018-03-28

申请号：EP16725090.1

申请日：2016-05-19

申请人： Université de Bordeaux ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： BARTHELEMY, Philippe ,  OUMZIL, Khalid

IPC分类号： C07H19/06 ,  C07H19/10 ,  C12N15/87

CPC分类号： C07H19/06 ,  A61K9/1272 ,  A61P35/00 ,  C07H19/073 ,  C07H19/10 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/32

摘要： The invention relates to new nucleoside-lipid compounds with pH-sensitive dialkylorthoester chains, to the process for their preparation and to their uses, in particular their use for transportation or vectorization of at least one therapeutic agent.