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公开(公告)号：EP3359531B1
公开(公告)日：2020-08-19
申请号：EP16778310.9
申请日：2016-10-03
发明人： ATKINSON, Stephen, John , DEMONT, Emmanuel, Hubert , HARRISON, Lee, Andrew , HAYHOW, Thomas, George, Christopher , LINDON, Matthew, J. , PRESTON, Alexander, G. , SEAL, Jonathan, Thomas , WALL, Ian, David , WATSON, Robert, J. , WOOLVEN, James, Michael
IPC分类号： C07D401/14 , C07D213/82 , C07D401/12 , A61K31/4412 , A61K31/4439 , A61P35/00
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公开(公告)号：EP3317271B1
公开(公告)日：2020-05-13
申请号：EP16735714.4
申请日：2016-06-30
发明人： BRACKLEY, III, James A. , GRAVES, III, Alan Peterson , KNIGHT, Steven David , MCNULTY, Kenneth C. , NEWLANDER, Kenneth Allen , TIAN, Xinrong
IPC分类号： C07D409/14 , C07D495/04 , A61K31/55 , A61K31/4545 , A61P35/00
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公开(公告)号：EP3440075B1
公开(公告)日：2020-01-29
申请号：EP17715714.6
申请日：2017-04-05
发明人： ATKINSON, Stephen, John , DEMONT, Emmanuel, Hubert , HARRISON, Lee, Andrew , PRESTON, Alexander, G. , SEAL, Jonathan, Thomas , WALL, Ian, David , WATSON, Robert, J. , WOOLVEN, James, Michael
IPC分类号： C07D405/12
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公开(公告)号：EP3589618A1
公开(公告)日：2020-01-08
申请号：EP18712082.9
申请日：2018-02-27
发明人： ATKINSON, Stephen John , DEMONT, Emmanuel Hubert , HARRISON, Lee Andrew , LIWICKI, Gemma Michele , LUCAS, Simon Christopher Cranko , PRESTON, Alexander G , SEAL, Jonathan, Thomas , WALL, Ian David , WATSON, Robert J
IPC分类号： C07D231/14 , C07D403/12 , C07D401/14 , C07D405/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/415 , A61K31/4155
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公开(公告)号：EP3589615A1
公开(公告)日：2020-01-08
申请号：EP18712081.1
申请日：2018-02-27
发明人： ATKINSON, Stephen John , DEMONT, Emmanuel Hubert , HARRISON, Lee Andrew , LEVERNIER, Etienne , PRESTON, Alexander G , SEAL, Jonathan, Thomas , WALL, Ian David , WATSON, Robert J , WOOLVEN, James Michael
IPC分类号： C07D213/81 , C07D401/06 , C07D413/12 , C07D417/12 , A61K31/4436 , A61P37/00
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36.发明公开
公开(公告)号：EP3507283A1
公开(公告)日：2019-07-10
申请号：EP17758878.7
申请日：2017-08-31
发明人： BAXTER, Andrew , BROWN, John, Alexander , HIRST, David , HUMPHREYS, Philip , JONES, Katherine, Louise , PATEL, Vipulkumar, Kantibhai
IPC分类号： C07D401/14 , C07D405/14 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , C07D401/04 , A61P29/00 , A61P35/00
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37.发明授权
公开(公告)号：EP3107915B1
公开(公告)日：2017-11-08
申请号：EP15706413.0
申请日：2015-02-18
发明人： BIGGADIKE, Keith , CHAMPIGNY, Aurelie Cecile , COE, Diane Mary , TAPE, Daniel Terence , SMITH, Stephen Allan
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P37/00 , A61P29/00
CPC分类号： C07D487/04 , A61K39/39 , A61K2039/55511
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公开(公告)号：EP3227275A1
公开(公告)日：2017-10-11
申请号：EP15801951.3
申请日：2015-11-19
发明人： BECHERER, J. David , CADILLA, Rodolfo , DEATON, David Norman , HAFFNER, Curt , HENKE, Brad Richard , PREUGSCHAT, Frank , SCHULTE, Christie
IPC分类号： C07D403/04
CPC分类号： C07D403/04
摘要： Compounds of Formula (I) and methods of treating diseases of metabolism by modulating cellular NAD+ levels through the inhibition of the CD38 enzyme, are disclosed. Formula (I).
摘要翻译： 公开了式（I）化合物和通过抑制CD38酶通过调节细胞NAD +水平治疗代谢疾病的方法。 公式（I）。
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公开(公告)号：EP3221317A1
公开(公告)日：2017-09-27
申请号：EP15801271.6
申请日：2015-11-19
发明人： ELLIS, James Lamond , EVANS, Karen Anderson , FOX, Ryan Michael , MILLER, William Henry , SEEFELD, Mark Andrew
IPC分类号： C07D471/18 , A61K31/551 , A61P3/10 , A61P9/00 , A61P25/28
摘要： The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and for use in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
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公开(公告)号：EP3220918A1
公开(公告)日：2017-09-27
申请号：EP15804601.1
申请日：2015-11-19
发明人： ELLIS, James Lamond , EVANS, Karen Anderson , FOX, Ryan Michael , MILLER, William Henry , SEEFELD, Mark Andrew
IPC分类号： A61K31/551 , A61P3/10 , A61P9/00 , A61P25/28 , C07D487/18
CPC分类号： C07D471/18 , A61K31/551 , A61K31/5517 , C07D487/18 , C07D519/00
摘要： The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and for use in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
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