公开(公告)号：EP1603587A1

公开(公告)日：2005-12-14

申请号：EP04717465.1

申请日：2004-03-04

申请人： GENZYME CORPORATION

发明人： TEICHER, Beverly ,  ROBERTS, Bruce

IPC分类号： A61K38/17 ,  C12N15/861 ,  A61P9/00

CPC分类号： C07K16/2851 ,  A61K38/1709 ,  A61K48/00 ,  A61K2039/505 ,  C07K2317/21

摘要： The methods and compositions provided herein promote angiogenesis using exogenous expression of Tumor Endothelial Marker (TEM) 1, TEM 9, or TEM 17 protein, or biologically active fragments thereof, in endothelial cells. Also provided are methods to identify inhibitors of angiogenesis in mice transgenic for TEM 1, TEM 9, or TEM 17 proteins. Therefore, these methods and compositions are useful in the accelerating or augmenting wound healing, treatment of anoxic tissues (e.g., cardiac muscle), ulcers, and transplanted tissues, particularly vascular grafts, in vertebrates.

公开(公告)号：EP0587266B1

公开(公告)日：2005-10-26

申请号：EP93303513.1

申请日：1993-05-06

申请人： GEN-PROBE INCORPORATED

发明人： Kacian, Daniel Louis ,  McAllister, Diane Lisa ,  McDonough, Sherrol Hoffa ,  Dattagupta, Nanibhushan

IPC分类号： C12Q1/68

CPC分类号： C07H21/00 ,  C12Q1/6848 ,  C12Q1/686 ,  C12Q1/6865 ,  C12Q1/689

公开(公告)号：EP0723443B1

公开(公告)日：2004-07-14

申请号：EP94931355.5

申请日：1994-10-14

申请人： MYOTECH, INC.

发明人： Hubbard, David R., Jr.

IPC分类号： A61K31/415 ,  A61K31/135 ,  A61K31/395 ,  A61P21/00

CPC分类号： A61K31/57 ,  A61K31/00 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/357 ,  A61K31/395 ,  A61K31/415 ,  A61K31/417 ,  A61K31/4174 ,  A61K31/454 ,  A61K31/475 ,  A61K31/517 ,  A61K45/06 ,  A61K2300/00

摘要： Methods are provided for intramuscular needle diagnosis and treatment of muscle pain that is the result of sympathetically mediated spindle spasm. Two simultaneous needle EMG needle recordings are used to establish the presence of and magnitude of the 'trigger points' in painful muscle. The abnormal muscle activity so identified is then treated by blocking the sympathetic activation of the muscle with an alpha receptor antagonist, e.g. phentolamine, phenoxybenzamine and guanethidine.

公开(公告)号：EP1289566A1

公开(公告)日：2003-03-12

申请号：EP01934159.3

申请日：2001-05-30

申请人： ISIS INNOVATION LIMITED

发明人： HYDE, Stephen Charles

IPC分类号： A61K48/00 ,  A61K31/70 ,  A61P11/00

CPC分类号： A61K48/00

摘要： The human Ubiquitin C promoter is proposed as a highly advantageous promoter for use in airway gene therapy.

公开(公告)号：EP1274848A2

公开(公告)日：2003-01-15

申请号：EP01927207.9

申请日：2001-04-18

申请人： PIONEER HI-BRED INTERNATIONAL, INC.

发明人： MAHAJAN, Pramod, B.

IPC分类号： C12N15/55 ,  C12N15/29 ,  C12N15/82 ,  C12N9/22 ,  C07K14/415 ,  A01H5/00

CPC分类号： C12N15/8201 ,  C07K14/415 ,  C12N9/22 ,  C12N15/8205 ,  C12N15/8207

摘要： The invention provides isolated Mre 11 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering Mre11 levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions.

公开(公告)号：EP1270594A1

公开(公告)日：2003-01-02

申请号：EP02016350.7

申请日：1997-03-21

申请人： Synaptica Limited

发明人： Greenfield, Susan Adele ,  Vaux, David John Talbutt

IPC分类号： C07K16/40 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/40 ,  A61K38/00 ,  A61K2039/505 ,  C12N9/18

摘要： The present invention provides antibodies to an isolated peptide, said peptide being selected from the peptide of sequence AEFHRWSSYMVHWK and functional variants thereof which (i) comprise at least 6 amino acids residues and have at least 70% homology with part or all of said sequence and (ii) retain the calcium channel modulatory function of the peptide of said sequence.

摘要翻译： 本发明提供对分离的肽的抗体，所述肽选自序列AEFHRWSSYMVHWK的肽及其功能变体，其（i）包含至少6个氨基酸残基并且与所述序列的部分或全部具有至少70％的同源性， （ii）保留所述序列的肽的钙通道调节功能。

公开(公告)号：EP1263945A2

公开(公告)日：2002-12-11

申请号：EP01949003.6

申请日：2001-01-30

申请人： PIONEER HI-BRED INTERNATIONAL, INC.

发明人： BRUCE, Wesley, B.

IPC分类号： C12N15/00

CPC分类号： C12N15/8261 ,  C07K14/415 ,  Y02A40/146

摘要： The invention provides isolated root transcriptional factor nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering root transcriptional factor levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions.

公开(公告)号：EP1260520A3

公开(公告)日：2002-12-04

申请号：EP02006768.2

申请日：1996-12-17

申请人： MYRIAD GENETICS, INC. ,  Endo Recherche Inc. ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  HSC Research and Development Limited Partnership

发明人： Tavtigian, Sean V. ,  Kamb, Alexander ,  Simard, Jacques ,  Couch, Fergus ,  Rommens, Johanna M. ,  Weber, Barbara L.

IPC分类号： C07K14/82 ,  C12Q1/68 ,  G01N33/53 ,  A01K67/027

CPC分类号： C07K14/4703 ,  A61K48/00 ,  Y10S530/828

摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer predisposing gene (BRCA2), some mutant alleles of which cause susceptibility to cancer, in particular breast cancer. More specifically, the invention relates to germline mutations in the BRCA2 gene and their use in the diagnosis of predisposition to breast cancer. The present invention further relates to somatic mutations in the BRCA2 gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer. Additionally, the invention relates to somatic mutations in the BRCA2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA2 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA2 gene for mutations, which are useful for diagnosing the predisposition to breast cancer.

公开(公告)号：EP1255825A2

公开(公告)日：2002-11-13

申请号：EP01910583.2

申请日：2001-02-13

申请人： PIONEER HI-BRED INTERNATIONAL, INC.

发明人： ALBERTSEN, Marc, C. ,  FOX, Timothy, W. ,  GARNAAT, Carl, W. ,  HUFFMAN, Gary ,  KENDALL, Timmy, L.

IPC分类号： C12N15/09 ,  C12N15/82

CPC分类号： C07K14/415 ,  C12N15/8231 ,  C12N15/8289

摘要： The present invention relates to an isolated nucleic acid sequence encoding the Ms45 male tissue-preferred regulatory region. In one aspect this invention relates to the use of this male tissue-preferred regulatory region in mediating fertility. An example of such use is the production of hybrid seed such as in a male sterility system. The Ms45 male tissue-preferred regulatory region can be operably linked with exogenous genes, such as those encoding cytotoxins, complementary nucleotidic units and inhibitory molecules. This invention also relates to plant cells, plant tissue and differentiated plants which contain the regulatory region in this invention.

公开(公告)号：EP1250358A1

公开(公告)日：2002-10-23

申请号：EP01946869.3

申请日：2001-01-25

申请人： Pharma Pacific Pty. Ltd.

发明人： TOVEY, Michael, Gerard ,  EID, Pierre

IPC分类号： C07K14/715 ,  C07K14/56 ,  C07K7/06

CPC分类号： C07K14/7156 ,  A61K38/00

摘要： The invention provides peptides of about 9-12 amino acids having a sequence derived from the interferon binding site of the IFNAR1 chain of the Type 1-interfereon (Type 1-IFN) receptor for use as a Type 1-IFN antagonist. In particular, the invention provides peptides having the 9 mer sequence FSSLKLNVY (Sequence ID no. 1) and analogues thereof for use as Type 1-IFN antagonists. Particularly preferred for this purpose is the peptide of Sequence ID no. 1 and analogues thereof including Sequence ID no. 1 having an additional asparagine residue (N) at the C-terminus and/or additional glutamic acid residue (E) at the N-terminus.