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31.发明公开USE OF IMPEDANCE-BASED CYTOLOGICAL PROFILING TO CLASSIFY CELLULAR RESPONSE PROFILES UPON EXPOSURE TO BIOLOGICALLY ACTIVE AGENTS 审中-公开使用细胞基于阻抗的分析信息分类细胞反应型材除了生理活性物质
公开(公告)号：EP2064644A2
公开(公告)日：2009-06-03
申请号：EP07838594.5
申请日：2007-09-20
Applicant: Acea Biosciences, Inc.
Inventor： WANG, Xiaobo , ABASSI, Yama, A. , ZHANG, Wenfu , XU, Xiao
IPC: G06F19/00
CPC classification number: G01N33/54373 , G01N33/5005 , G01N33/5438 , G06F19/24
Abstract: The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The grouping of similar cellular response profiles allows the correlation between agent and mechanism, thus allowing for the identification of potential therapeutic applications of agents or further study of cellular responses or mechanisms.
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公开(公告)号：EP1742635A2
公开(公告)日：2007-01-17
申请号：EP05779301.0
申请日：2005-04-20
Applicant: Acea Biosciences, Inc.
Inventor： XU, Xiao , AN, Haoyun , WANG, Xiaobo
IPC: A61K31/513 , A61K31/444 , A61K31/381 , A61K31/095
CPC classification number: C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
Abstract: The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
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33.发明公开
公开(公告)号：EP1527328A2
公开(公告)日：2005-05-04
申请号：EP03751801.6
申请日：2003-07-18
Applicant: Acea Biosciences, Inc.
Inventor： WANG, Xiaobo , XU, Xiao
IPC: G01N1/00
CPC classification number: G01N33/5005 , G01N15/12 , G01N33/54366 , G01N33/5438
Abstract: A device for monitoring the migration or invasion of a biological particle such as a cell is disclosed. The device includes an upper chamber adapted to receive and retain a cell sample, a lower chamber having at least two electrodes, and a biocompatible porous membrane having a porosity sufficient to allow cells to migrate therethrough. The membrane is disposed in the device so as to separate the upper and lower chambers from one another. Migration of cells through the porous membrane permits contact between the migrating cells and one or more electrodes of the lower chamber. The contact provides a detectable change in impedance between or among the electrodes.
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公开(公告)号：EP3071951B1
公开(公告)日：2019-10-30
申请号：EP14863825.7
申请日：2014-11-19
Applicant: ACEA Biosciences, Inc.
Inventor： LI, Nan , CHEN, Ye , CHUNG, Hyunsun , LI, Zengqiang , WANG, Xiaobo
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35.发明公开
公开(公告)号：EP3485252A1
公开(公告)日：2019-05-22
申请号：EP17828600.1
申请日：2017-07-15
Applicant: ACEA Biosciences Inc.
Inventor： LI, Nan , KONG, Lingbo , WU, Jian , CHENG, Tingting , QING, Yangde , WANG, Xiaobo
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Patent Agency Ranking
公开(公告)号：EP3377607A1
公开(公告)日：2018-09-26
申请号：EP16867327.5
申请日：2016-11-21
Applicant: ACEA Biosciences Inc.
Inventor： WANG, Xiaobo , ABASSI, Yama A. , LI, Nan , MUIR, Lincoln , XU, Xiao
CPC classification number: G01N33/5011 , C12M1/3407 , C12N13/00 , G01N33/48707 , G01N33/502 , G01N33/5047 , G01N2800/52 , G01N2800/7028
Abstract: Methods of assessing cytolysis of cancer cells, including providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, wherein the device comprises a well for receiving cells and an electrode array at a base of the well; adding target cells characterized as cancer cells to the well; adding effector cells to the well to form a test well, wherein the effector cells are immune cells obtained or derived from a same patient as the target cells; monitoring cell-substrate impedance of the test well before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedance; and determining effectiveness of effector cell killing of the target cells by comparing the impedance or impedance based parameter over time.
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公开(公告)号：EP3173414A1
公开(公告)日：2017-05-31
申请号：EP17150851.8
申请日：2008-07-17
Applicant: ACEA Biosciences Inc.
Inventor： AN, Haoyun , XI, Biao , ABASSI, Yama , WANG, Xiaobo , XU, Xiao
IPC: C07D487/04 , C07D498/04 , C07D513/04 , A61K31/429 , A61K31/519 , A61P35/00
CPC classification number: C07D487/04 , C07D498/04 , C07D513/04
Abstract: Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
Abstract translation: 公开了具有用杂芳基五元环取代的稠合双环杂芳族环系的新型化合物。 这些化合物抑制多种类型癌细胞的生长，因此可用于治疗癌症。 用监测细胞生长/迁移的系统证明了这些化合物的功效，其显示它们是癌细胞生长和/或迁移的有效抑制剂。 另外，本发明的化合物显示出可以停止体内肿瘤的生长，并且减小体内肿瘤的大小。 公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗癌症的方法。
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公开(公告)号：EP3170825A1
公开(公告)日：2017-05-24
申请号：EP16202341.0
申请日：2013-07-11
Applicant: ACEA Biosciences Inc.
Inventor： XU, Xiao , WANG, Xiaobo , MAO, Long , ZHAO, Li , XI, Biao
IPC: C07D487/04 , A61K31/52 , A61P35/00
CPC classification number: C07D487/04
Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways.
Abstract translation: 本发明涉及某些吡咯并嘧啶衍生物，含有它们的药物组合物及其使用方法，包括治疗增殖紊乱和与激酶失调相关的其它疾病的方法（例如但不限于EGFR（包括HER ），Alk，PDGFR，BLK，BMX / ETK，BTK，FLT3（D835Y），ITK，JAK1，JAK2，JAK3，TEC和TXK）和/或各自的途径。
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公开(公告)号：EP2880035B9
公开(公告)日：2017-05-17
申请号：EP13745491.4
申请日：2013-07-11
Applicant: ACEA Biosciences Inc.
Inventor： XU, Xiao , WANG, Xiaobo , MAO, Long , ZHAO, Li , XI, Biao
IPC: C07D487/04 , A61K31/52 , A61P35/00
CPC classification number: C07D487/04
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公开(公告)号：EP2188271B1
公开(公告)日：2017-01-11
申请号：EP08827232.3
申请日：2008-07-17
Applicant: Acea Biosciences, Inc.
Inventor： AN, Haoyun , XI, Biao , ABASSI, Yama , WANG, Xiaobo , XU, Xiao
IPC: C07D487/04 , C07D498/04 , C07D513/04 , A61K31/429 , A61K31/519 , A61P35/00
CPC classification number: C07D487/04 , C07D498/04 , C07D513/04
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