公开(公告)号：EP3188726A4

公开(公告)日：2018-05-30

申请号：EP14895389

申请日：2014-06-19

申请人： SHORR ROBERT ,  RODRIGUEZ ROBERT ,  BINGHAM PAUL ,  BOTEJU LAKMAL W ,  MARECEK JAMES

发明人： KWOK THOMAS

IPC分类号： C07C321/20 ,  A61K31/20 ,  A61P35/00 ,  C07C323/12 ,  C07C323/60 ,  C07C323/66 ,  C07D257/04 ,  C07F9/54

CPC分类号： C07F9/5442 ,  C07C321/20 ,  C07C323/12 ,  C07C323/25 ,  C07C323/60 ,  C07C323/66 ,  C07D257/04

摘要： Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations comprising such analogs or derivatives and pharmaceutically-acceptable carriers therefor, are useful for the treatment, prevention, imaging, and/or diagnosis of medical disorders.

公开(公告)号：EP3188726A1

公开(公告)日：2017-07-12

申请号：EP14895389.6

申请日：2014-06-19

申请人： Shorr, Robert ,  Rodriguez, Robert ,  Bingham, Paul ,  Boteju, Lakmal W. ,  Marecek, James

发明人： KWOK, Thomas

IPC分类号： A61K31/20 ,  A61P35/00 ,  C07C381/00

CPC分类号： C07F9/5442 ,  C07C321/20 ,  C07C323/12 ,  C07C323/25 ,  C07C323/60 ,  C07C323/66 ,  C07D257/04

摘要： Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations comprising such analogs or derivatives and pharmaceutically-acceptable carriers therefor, are useful for the treatment, prevention, imaging, and/or diagnosis of medical disorders.

公开(公告)号：EP2142500B1

公开(公告)日：2013-07-31

申请号：EP08733689.7

申请日：2008-03-28

申请人： Contech Enterprises Inc.

发明人： GRIES, Regine ,  CAMPBELL, Cory ,  KHASKIN, Grigori ,  AVELINO, Norman ,  GRIES, Gerhard

IPC分类号： A61K31/10 ,  A61K31/382 ,  A61K8/46 ,  A61K8/49 ,  A61P33/14 ,  A61Q17/02 ,  C07C319/14 ,  C07C321/18 ,  C07C321/20 ,  C07C321/28 ,  C07C323/12 ,  C07D335/02 ,  A01N43/18 ,  A01N41/12

CPC分类号： C07D335/02 ,  A01N31/02 ,  A01N41/12 ,  A01N43/24 ,  A01N43/28 ,  A01N43/32 ,  A61K8/46 ,  A61K8/4986 ,  A61Q17/02 ,  C07C321/18 ,  C07C321/20 ,  C07C321/28 ,  C07C323/12

公开(公告)号：EP2142500A1

公开(公告)日：2010-01-13

申请号：EP08733689.7

申请日：2008-03-28

申请人： Contech Enterprises Inc.

发明人： GRIES, Regine ,  CAMPBELL, Cory ,  KHASKIN, Grigori ,  AVELINO, Norman ,  GRIES, Gerhard

IPC分类号： C07C323/12 ,  A61K31/10 ,  A61K31/382 ,  A61K8/46 ,  A61K8/49 ,  A61P33/14 ,  A61Q17/02 ,  C07C319/14 ,  C07C321/18 ,  C07C321/20 ,  C07C321/28 ,  C07D335/02 ,  A01N43/18 ,  A01N41/12 ,  A01P17/00

CPC分类号： C07D335/02 ,  A01N31/02 ,  A01N41/12 ,  A01N43/24 ,  A01N43/28 ,  A01N43/32 ,  A61K8/46 ,  A61K8/4986 ,  A61Q17/02 ,  C07C321/18 ,  C07C321/20 ,  C07C321/28 ,  C07C323/12

摘要： This invention relates to compositions of one or more compounds that incorporate one or more allyl sulfide, allyl disulfide or allyl polysulfide moieties, or one or more allyl sulfide, allyl disulfide or allyl polysulfide moieties and one or more hydroxyl groups, used in effective amount in formulations, including emulsions, to repel blood-feeding ectoparasitic arthropods, including mosquitoes, and to deter them from landing and feeding when applied to the skin, clothing or environment of animals, including humans. Said compounds can include, but are not limited to, 8-allyl-sulfanyloctan-1-ol. This invention also relates to compositions comprising one or more of said compounds in further combination with other arthropod repellent and deterrent compounds, including vanillin. These compounds may be formulated with inert ingredients to form a liquid, gel, paste, soap, spray, aerosol or powder.

公开(公告)号：EP1180024A4

公开(公告)日：2002-06-19

申请号：EP00919829

申请日：2000-03-30

申请人： UNIV TEMPLE

发明人： REDDY E PREMKUMAR ,  REDDY M V RAMANA

IPC分类号： A61P35/00 ,  A61K31/10 ,  C07C317/10 ,  C07C317/18 ,  C07C321/20 ,  C07C323/07

CPC分类号： C07C321/20 ,  C07C317/10 ,  C07C323/07

公开(公告)号：EP0883606A1

公开(公告)日：1998-12-16

申请号：EP97903184.0

申请日：1997-02-26

申请人： APOTEX INC.

发明人： KARIMIAN, Khashayar ,  TAM, Tim, F. ,  DESILETS, Denis ,  LEE, Sue ,  CAPPELLETTO, Tullio ,  LI, Wanren

IPC分类号： A61K31 ,  A61P1 ,  A61P43 ,  C07C319 ,  C07C321 ,  C07D285 ,  C07D513

CPC分类号： C07D285/08 ,  C07C319/24 ,  C07C321/20 ,  C07C321/22

摘要： Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The process is useful pharmacologically, in inhibiting certain thiol-containing enzymes such as H+/K+-ATPase (the proton pump), and industrially, in selective removal of thiol compounds from gas or liquid mixtures.

公开(公告)号：EP0513619A3

公开(公告)日：1994-01-26

申请号：EP92107528.9

申请日：1992-05-04

申请人： BAYER AG

发明人： Podder, Chiraranjan, Dr. ,  Schlesmann, Harro, Dr. ,  Eichenauer, Herbert, Dr.

IPC分类号： C07C39/00 ,  C07C321/00 ,  C08K5/00

CPC分类号： C08K5/372 ,  C07C39/06 ,  C07C321/18 ,  C07C321/20 ,  C07C321/28 ,  C07C2601/16 ,  C08K5/13 ,  C08L51/04

摘要： Mischungen aus Thioenolethern und phenolischen Antioxidantien wirken stabilisierend auf sauerstoffempfindliche Polymere, insbesondere kautschukmodifizierte Polymere.

摘要翻译： 硫醇烯醚和酚类抗氧化剂的混合物对氧敏感聚合物，特别是橡胶改性聚合物具有稳定作用。

公开(公告)号：EP2159219A3

公开(公告)日：2010-12-15

申请号：EP09011543.7

申请日：2007-03-01

申请人： Teva Pharmaceutical Industries Ltd.

发明人： Moshkovits-Kaptsan, Rinat ,  Braude, Viviana ,  Chen, Kobi ,  Adler, Miri

IPC分类号： C07C315/06 ,  C07C317/44

CPC分类号： C07C315/06 ,  C07B57/00 ,  C07B2200/07 ,  C07C319/24 ,  C07C317/44 ,  C07C321/20

摘要： The invention encompasses a process for reducing the amount of bis(diphenylmethyl)disulfide in armodafinil, which comprises suspending armodafinil in a C 5 to C 12 hydrocarbon.

公开(公告)号：EP1954652A2

公开(公告)日：2008-08-13

申请号：EP07752169.8

申请日：2007-03-01

申请人： Teva Pharmaceutical Industries Ltd

发明人： MOSHKOVITS-KAPTSAN, Rinat ,  BRAUDE, Viviana ,  CHEN, Kobi ,  ADLER, Miri

IPC分类号： C07B57/00 ,  C07C315/06 ,  C07C317/44 ,  C07C319/24 ,  C07C321/20 ,  A61K31/192 ,  A61P25/00

CPC分类号： C07C315/06 ,  C07B57/00 ,  C07B2200/07 ,  C07C319/24 ,  C07C317/44 ,  C07C321/20

摘要： The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the optical resolution of modafinic acid with (R)-α-naphthylethylamine and its conversion into armodafinil; (ii) (R)-modafinic acid containing less than 2% area by HPLC of (S)-modifinic acid; (iii) a process for the preparation of C1-2 alkyl ester of (R)-modafinic acid from (R)-modafinic acid by reaction with methanol or ethanol in the presence of at least one acidic reagent and its conversion into armodafinil; (iv) armodafinil with less than 0.5% area by HPLC of (S)-modafinil entantiomer, a pharmaceutical composition containing it and process for the preparation of this composition; (v) armodafinil with less than 0.1% area by HPLC of modafinic acid, a pharmaceutical composition containing it and process for the preparation of this composition; (vi) a process for the reduction of modafinic acid content in armodafjnil by contacting a solution with activated basic or neutral alumina; (vii) armodafinil with less than 0.2% area by HPLC of bis(diphenylmethyl) disulphide (R-MDF-DS), a pharmaceutical composition containing it and process for the preparation of this composition; (viii) a process for the preparation of R-MDF-DS from diphenylmethanethiol acetate; and (ix) a process for the reduction of R-MDF-DS content in armodafinil by suspending it in a C5-10 hydrocarbon.

公开(公告)号：EP1264547A1

公开(公告)日：2002-12-11

申请号：EP01113787.4

申请日：2001-06-06

申请人： Givaudan SA

发明人： Grab, Willi ,  Ratcliff, Damian John ,  Furrer, Stefan

IPC分类号： A23L1/226 ,  C11B9/00 ,  C07C321/20 ,  C07C327/22

CPC分类号： C07C323/16 ,  A23L27/204 ,  C07C321/10 ,  C07C321/20 ,  C07C327/22 ,  C11B9/0061

摘要： Flavour and fragrance compositions comprising 1-mercapto-1-arylalkanes or derivatives thereof.

摘要翻译： 包含1-巯基-1-芳基烷烃或其衍生物的风味和香料组合物。