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1.发明授权
公开(公告)号：EP1527328B1
公开(公告)日：2009-09-09
申请号：EP03751801.6
申请日：2003-07-18
Applicant: Acea Biosciences, Inc.
Inventor： WANG, Xiaobo , XU, Xiao
CPC classification number: G01N33/5005 , G01N15/12 , G01N33/54366 , G01N33/5438
Abstract: A device for monitoring the migration or invasion of a biological particle such as a cell is disclosed. The device includes an upper chamber adapted to receive and retain a cell sample, a lower chamber having at least two electrodes, and a biocompatible porous membrane having a porosity sufficient to allow cells to migrate therethrough. The membrane is disposed in the device so as to separate the upper and lower chambers from one another. Migration of cells through the porous membrane permits contact between the migrating cells and one or more electrodes of the lower chamber. The contact provides a detectable change in impedance between or among the electrodes.
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公开(公告)号：EP3170825B1
公开(公告)日：2019-04-10
申请号：EP16202341.0
申请日：2013-07-11
Applicant: ACEA Biosciences Inc.
Inventor： XU, Xiao , WANG, Xiaobo , MAO, Long , ZHAO, Li , XI, Biao
IPC: C07D487/04 , A61K31/52 , A61P35/00
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公开(公告)号：EP1742635B1
公开(公告)日：2018-03-07
申请号：EP05779301.0
申请日：2005-04-20
Applicant: Acea Biosciences, Inc.
Inventor： XU, Xiao , AN, Haoyun , WANG, Xiaobo
IPC: C07C321/20 , C07C323/07 , C07C323/16 , C07C323/20 , C07D213/52 , C07D333/54
CPC classification number: C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
Abstract: The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
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公开(公告)号：EP2536719A1
公开(公告)日：2012-12-26
申请号：EP11706123.4
申请日：2011-02-18
Applicant: Acea Biosciences, Inc.
Inventor： MAO, Long , WANG, Xiaobo , XU, Xiao , ZHAO, Li , LIU, Jia
IPC: C07D471/04 , C07D513/04 , A61K31/437 , A61K31/4188 , A61P35/00
CPC classification number: C07D471/04 , C07D513/04
Abstract: Novel compounds having a fused bicyclic hetero aromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors
in vivo , and to reduce the size of tumors
in vivo . Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.-
5.发明公开USE OF IMPEDANCE-BASED CYTOLOGICAL PROFILING TO CLASSIFY CELLULAR RESPONSE PROFILES UPON EXPOSURE TO BIOLOGICALLY ACTIVE AGENTS 审中-公开使用细胞基于阻抗的分析信息分类细胞反应型材除了生理活性物质
公开(公告)号：EP2064644A2
公开(公告)日：2009-06-03
申请号：EP07838594.5
申请日：2007-09-20
Applicant: Acea Biosciences, Inc.
Inventor： WANG, Xiaobo , ABASSI, Yama, A. , ZHANG, Wenfu , XU, Xiao
IPC: G06F19/00
CPC classification number: G01N33/54373 , G01N33/5005 , G01N33/5438 , G06F19/24
Abstract: The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The grouping of similar cellular response profiles allows the correlation between agent and mechanism, thus allowing for the identification of potential therapeutic applications of agents or further study of cellular responses or mechanisms.
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Patent Agency Ranking
公开(公告)号：EP1742635A2
公开(公告)日：2007-01-17
申请号：EP05779301.0
申请日：2005-04-20
Applicant: Acea Biosciences, Inc.
Inventor： XU, Xiao , AN, Haoyun , WANG, Xiaobo
IPC: A61K31/513 , A61K31/444 , A61K31/381 , A61K31/095
CPC classification number: C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
Abstract: The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
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7.发明公开
公开(公告)号：EP1527328A2
公开(公告)日：2005-05-04
申请号：EP03751801.6
申请日：2003-07-18
Applicant: Acea Biosciences, Inc.
Inventor： WANG, Xiaobo , XU, Xiao
IPC: G01N1/00
CPC classification number: G01N33/5005 , G01N15/12 , G01N33/54366 , G01N33/5438
Abstract: A device for monitoring the migration or invasion of a biological particle such as a cell is disclosed. The device includes an upper chamber adapted to receive and retain a cell sample, a lower chamber having at least two electrodes, and a biocompatible porous membrane having a porosity sufficient to allow cells to migrate therethrough. The membrane is disposed in the device so as to separate the upper and lower chambers from one another. Migration of cells through the porous membrane permits contact between the migrating cells and one or more electrodes of the lower chamber. The contact provides a detectable change in impedance between or among the electrodes.
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公开(公告)号：EP3019496A2
公开(公告)日：2016-05-18
申请号：EP14748351.5
申请日：2014-07-11
Applicant: ACEA Biosciences, Inc.
Inventor： XU, Xiao , WANG, Xiaobo , MAO, Long , ZHAO, Li , XI, Biao
IPC: C07D417/12 , C07D473/18 , C07D487/04 , C07D519/00 , A61K31/506 , A61P35/00 , C07D239/553 , C07D239/545 , C07D403/12
CPC classification number: C07D239/545 , C07D239/553 , C07D403/12 , C07D417/12 , C07D473/18 , C07D487/04 , C07D519/00
Abstract: The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.
Abstract translation: 本发明涉及药物化合物，组合物和方法，尤其涉及用于治疗和/或预防增殖性疾病，癌症，肿瘤，炎性疾病，自身免疫性疾病，牛皮癣，干燥的组合物和方法 （包括但不限于）EGFR（包括HER），Alk，PDGFR，BLK，BMX / ETK，FLT3（D835Y），ITK ，TEC，TXK，BTK或JAK，以及各自的途径。
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9.发明公开SYSTEM AND METHOD FOR MONITORING CARDIOMYOCYTE BEATING, VIABILITY AND MORPHOLOGY AND FOR SCREENING FOR PHARMACOLOGICAL AGENTS WHICH MAY INDUCE CARDIOTOXICITY OR MODULATE CARDIOMYOCYTE FUNCTION 审中-公开系统和监测方法的震撼，心肌的活力和形态和SCRENNING的活性成分KARDIOTOXIZITÄTSINDUKTOREN或调节心脏肌肉细胞功能
公开(公告)号：EP2427543A1
公开(公告)日：2012-03-14
申请号：EP10772804.0
申请日：2010-05-05
Applicant: Acea Biosciences, Inc.
Inventor： WANG, Xiaobo , OUYANG, Wei , LI, Nan , XI, Biao , ABASSI, Yama A. , XU, Xiao
IPC: C12M1/34
CPC classification number: G01N33/48728
Abstract: Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.
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10.发明公开LABEL-FREE MONITORING OF EXCITATION-CONTRACTION COUPLING AND EXCITABLE CELLS USING IMPEDANCE BASED SYSTEMS WITH MILLISECOND TIME RESOLUTION 有权MARK免费监测机电耦合和兴奋细胞系统研究基地阻抗MILLISECONDS时间分辨率BASIS
公开(公告)号：EP2291645A1
公开(公告)日：2011-03-09
申请号：EP09743426.0
申请日：2009-05-05
Applicant: Acea Biosciences, Inc.
Inventor： WANG, Xiaobo , ABASSI, Yama , XI, Biao , ZHANG, Wen, Fu , XU, Xiao
CPC classification number: G01N33/4836
Abstract: Systems and methods for improved monitoring of excitation-contraction coupling and excitable cells are provided, which provide millisecond time resolution. The system is capable of continuously monitoring excitation-contraction coupling in a relatively high-throughput manner. The system includes a device for monitoring cell-substrate impedance, an impedance analyzer capable of impedance measurements at millisecond time resolution, electronic circuitry that can engage the device and selectively connect two or more electrode arrays of the device to the impedance analyzer and a software program that controls the electronic circuitry and records and analyzes data obtained from the impedance analyzer.
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