公开(公告)号：EP1355727A4

公开(公告)日：2007-04-11

申请号：EP01993185

申请日：2001-11-15

申请人： CIPHERGEN BIOSYSTEMS INC ,  EASTERN VIRGINIA MED SCHOOL

发明人： GAVIN EDWARD J ,  BRAGINSKY LEONID ,  RICH WILLIAM E ,  FUNG ERIC T ,  WRIGHT JR GEORGE L

IPC分类号： G01N27/62 ,  H01J49/40 ,  C12N15/00 ,  G01N27/64 ,  G01N31/00 ,  G01R23/16 ,  G06F19/00 ,  H01J49/00 ,  H01J49/16

CPC分类号： H01J49/0036 ,  G06F19/18 ,  G06F19/24

摘要： A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set (27) obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes (30) and each class is characterized by a different biological status. A classification model (54) is then formed. The classification model discriminates between classes in the class set.

公开(公告)号：EP1463944A4

公开(公告)日：2006-05-10

申请号：EP02806479

申请日：2002-12-20

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： DENG YUPING

IPC分类号： G01N33/53 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/567 ,  G01N33/569

CPC分类号： G01N33/5047 ,  G01N2333/705

摘要： A method for analyzing the effects of medicinal agents, and more particularly, an ex vivo method of analyzing the effects of medicinal agents on the human immune system is provided.

公开(公告)号：EP1509086A4

公开(公告)日：2005-08-10

申请号：EP03734032

申请日：2003-05-16

申请人： EASTERN VIRGINIA MED SCHOOL ,  UNIV VIRGINIA

发明人： SEMMES OLIVER JOHN IV ,  KUPFER GARY MICHAEL

IPC分类号： A61K45/00 ,  A61K31/7088 ,  A61K35/12 ,  A61K35/76 ,  A61K48/00 ,  A61P13/10 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  C07K14/15 ,  A01N63/00 ,  A01N37/18 ,  A01N43/04 ,  C07H21/02 ,  C07H21/04 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63

CPC分类号： C07K14/005 ,  A61K48/00 ,  C12N2740/14022 ,  C12N2740/14043

摘要： This invention is based on the finding that expression of an exogenous nucleic acid encoding a polypeptide having human T-cell leukemia virus type I (HTLV-1) Tax activity in p53 null cells results in a sensitization of those cells to DNA damaging agents. Therefore, the present invention is directed to a method of inducing cell death in p53 null cells, enhancing susceptibility to such DNA damaging agents, and the selective cell killing of p53 null cells. It has been found that retroviral vectors, and particularly lentiviral vectors, are suitable for the present invention to permit the transient expression of the HTLV-1 Tax protein in the p53 null cells, which sensitizes the cells.

公开(公告)号：EP1007647A4

公开(公告)日：2001-09-26

申请号：EP97912942

申请日：1997-10-30

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： VINIK AARON I ,  PITTENGER GARY I ,  RAFAELOFF RONIT ,  BARLOW SCOTT W

IPC分类号： C12N15/09 ,  C07K1/22 ,  C07K14/47 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C12N15/00 ,  C07H21/04

CPC分类号： C07K14/4733 ,  C07K2319/00